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• W2116475900 abstract "Gonococci undergo frequent and efficient natural transformation. Transformation occurs so often that the population structure is panmictic, with only one long-lived clone having been identified. This high degree of genetic exchange is likely necessary to generate antigenic diversity and allow the persistence of gonococcal infection within the human population. In addition to spreading different alleles of genes for surface markers and allowing avoidance of the immune response, transformation facilitates the spread of antibiotic resistance markers, a continuing problem for treatment of gonococcal infections. Transforming DNA is donated by neighbouring gonococci by two different mechanisms: autolysis or type IV secretion. All types of DNA are bound non-specifically to the cell surface. However, for DNA uptake, Neisseria gonorrhoeae recognizes only DNA containing a 10-base sequence (GCCGTCTGAA) present frequently in the chromosome of neisserial species. Type IV pilus components and several pilus-associated proteins are necessary for gonococcal DNA uptake. Incoming DNA is subject to restriction, making establishment of replicating plasmids difficult but not greatly affecting chromosomal transformation. Processing and integration of transforming DNA into the chromosome involves enzymes required for homologous recombination. Recent research on DNA donation mechanisms and extensive work on type IV pilus biogenesis and recombination proteins have greatly improved our understanding of natural transformation in N. gonorrhoeae. The completion of the gonococcal genome sequence has facilitated the identification of additional transformation genes and provides insight into previous investigations of gonococcal transformation. Here we review these recent developments and address the implications of natural transformation in the evolution and pathogenesis N. gonorrhoeae." @default.
• W2116475900 created "2016-06-24" @default.
• W2116475900 creator A5037603097 @default.
• W2116475900 creator A5053607368 @default.
• W2116475900 date "2005-11-09" @default.
• W2116475900 modified "2023-09-26" @default.
• W2116475900 title "Natural transformation of<i>Neisseria gonorrhoeae</i>: from DNA donation to homologous recombination" @default.
• W2116475900 cites W1529624745 @default.
• W2116475900 cites W1553774013 @default.
• W2116475900 cites W1568361430 @default.
• W2116475900 cites W1582426872 @default.
• W2116475900 cites W1584015664 @default.
• W2116475900 cites W1594008356 @default.
• W2116475900 cites W1604915411 @default.
• W2116475900 cites W1607830388 @default.
• W2116475900 cites W1834255690 @default.
• W2116475900 cites W1853007132 @default.
• W2116475900 cites W1892660453 @default.
• W2116475900 cites W1910872089 @default.
• W2116475900 cites W1940015778 @default.
• W2116475900 cites W1964447229 @default.
• W2116475900 cites W1974384008 @default.
• W2116475900 cites W1977311157 @default.
• W2116475900 cites W1978514959 @default.
• W2116475900 cites W1993114348 @default.
• W2116475900 cites W1996687747 @default.
• W2116475900 cites W2000196659 @default.
• W2116475900 cites W2000488021 @default.
• W2116475900 cites W2000617690 @default.
• W2116475900 cites W2003940862 @default.
• W2116475900 cites W2006258437 @default.
• W2116475900 cites W2009588703 @default.
• W2116475900 cites W2010719520 @default.
• W2116475900 cites W2021344369 @default.
• W2116475900 cites W2030800522 @default.
• W2116475900 cites W2033220306 @default.
• W2116475900 cites W2033686499 @default.
• W2116475900 cites W2040854131 @default.
• W2116475900 cites W2060810530 @default.
• W2116475900 cites W2062677544 @default.
• W2116475900 cites W2069713229 @default.
• W2116475900 cites W2077488719 @default.
• W2116475900 cites W2082151215 @default.
• W2116475900 cites W2095048146 @default.
• W2116475900 cites W2098392466 @default.
• W2116475900 cites W2106484287 @default.
• W2116475900 cites W2109588427 @default.
• W2116475900 cites W2113448488 @default.
• W2116475900 cites W2114200482 @default.
• W2116475900 cites W2115500377 @default.
• W2116475900 cites W2120183465 @default.
• W2116475900 cites W2120932770 @default.
• W2116475900 cites W2122593087 @default.
• W2116475900 cites W2124141485 @default.
• W2116475900 cites W2125387019 @default.
• W2116475900 cites W2129994092 @default.
• W2116475900 cites W2132878899 @default.
• W2116475900 cites W2136352151 @default.
• W2116475900 cites W2136560595 @default.
• W2116475900 cites W2136892795 @default.
• W2116475900 cites W2139216324 @default.
• W2116475900 cites W2144572563 @default.
• W2116475900 cites W2145049240 @default.
• W2116475900 cites W2146729661 @default.
• W2116475900 cites W2147890668 @default.
• W2116475900 cites W2148634126 @default.
• W2116475900 cites W2150203465 @default.
• W2116475900 cites W2155744911 @default.
• W2116475900 cites W2156335341 @default.
• W2116475900 cites W2157049474 @default.
• W2116475900 cites W2157931451 @default.
• W2116475900 cites W2165569346 @default.
• W2116475900 cites W2165946618 @default.
• W2116475900 cites W2167448600 @default.
• W2116475900 cites W2169692172 @default.
• W2116475900 cites W2170846381 @default.
• W2116475900 cites W2171097528 @default.
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• W2116475900 cites W2175634656 @default.
• W2116475900 cites W4249596264 @default.
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• W2116475900 doi "https://doi.org/10.1111/j.1365-2958.2005.04964.x" @default.
• W2116475900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16390436" @default.
• W2116475900 hasPublicationYear "2005" @default.
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