FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116492234> ?p ?o ?g. }

• W2116492234 endingPage "3452" @default.
• W2116492234 startingPage "3437" @default.
• W2116492234 abstract "Heterologous expression of bacterial virulence factors in Saccharomyces cerevisiae is a feasible approach to study their molecular function. The authors have previously reported that the Salmonella typhimurium SigD protein, a phosphatidylinositol phosphatase involved in invasion of the host cell, inhibits yeast growth, presumably by depleting an essential pool of phosphatidylinositol 4,5- bis phosphate, and also that a catalytically inactive version, SigD R468A , was able to arrest growth by a different mechanism that involved disruption of the actin cytoskeleton. This paper describes marked differences between the phenotypes elicited by expression of SigD and SigD R468A in yeast. First, expression of SigD R468A caused accumulation of large unbudded cells and loss of septin organization, while SigD expression caused none of these effects. Second, growth inhibition by SigD R468A was mediated by a cell cycle arrest in G2 dependent on the Swe1 morphogenetic checkpoint, but SigD-induced growth inhibition was cell cycle independent. And third, SigD caused strong activation of the yeast MAP kinase Slt2, whereas SigD R468A rather inactivated another MAP kinase, Kss1. In a screen for suppressors of SigD R468A -induced growth arrest by overexpression of a yeast cDNA library, the Cdc42 GTPase was isolated. Furthermore, SigD R468A was co-purified with Cdc42 from yeast lysates. It is concluded that the Salmonella SigD protein deprived of its phosphatase activity is able to disrupt yeast morphogenesis by interfering with Cdc42 function, opening the possibility that the SigD N-terminal region might directly modulate small GTPases from the host during infection." @default.
• W2116492234 created "2016-06-24" @default.
• W2116492234 creator A5012728403 @default.
• W2116492234 creator A5029415610 @default.
• W2116492234 creator A5065680509 @default.
• W2116492234 creator A5073054776 @default.
• W2116492234 date "2006-11-01" @default.
• W2116492234 modified "2023-09-30" @default.
• W2116492234 title "Inhibition of Cdc42-dependent signalling in Saccharomyces cerevisiae by phosphatase-dead SigD/SopB from Salmonella typhimurium" @default.
• W2116492234 cites W1600400967 @default.
• W2116492234 cites W1627263949 @default.
• W2116492234 cites W1778557300 @default.
• W2116492234 cites W1856170453 @default.
• W2116492234 cites W1900006748 @default.
• W2116492234 cites W1913433814 @default.
• W2116492234 cites W1964997225 @default.
• W2116492234 cites W1969959955 @default.
• W2116492234 cites W1972877825 @default.
• W2116492234 cites W1973513869 @default.
• W2116492234 cites W1980431822 @default.
• W2116492234 cites W1984875233 @default.
• W2116492234 cites W1985287781 @default.
• W2116492234 cites W1989621389 @default.
• W2116492234 cites W1989630349 @default.
• W2116492234 cites W1996223704 @default.
• W2116492234 cites W1999768397 @default.
• W2116492234 cites W2001531568 @default.
• W2116492234 cites W2004137182 @default.
• W2116492234 cites W2006166158 @default.
• W2116492234 cites W2006602610 @default.
• W2116492234 cites W2012598334 @default.
• W2116492234 cites W2018040911 @default.
• W2116492234 cites W2020109783 @default.
• W2116492234 cites W2021129192 @default.
• W2116492234 cites W2029521467 @default.
• W2116492234 cites W2040838736 @default.
• W2116492234 cites W2054511991 @default.
• W2116492234 cites W2056117178 @default.
• W2116492234 cites W2057886904 @default.
• W2116492234 cites W2057992913 @default.
• W2116492234 cites W2059881085 @default.
• W2116492234 cites W2063742383 @default.
• W2116492234 cites W2064856026 @default.
• W2116492234 cites W2072317853 @default.
• W2116492234 cites W2088882706 @default.
• W2116492234 cites W2089201018 @default.
• W2116492234 cites W2089543096 @default.
• W2116492234 cites W2094410791 @default.
• W2116492234 cites W2096322420 @default.
• W2116492234 cites W2101346616 @default.
• W2116492234 cites W2103143169 @default.
• W2116492234 cites W2104453682 @default.
• W2116492234 cites W2105912776 @default.
• W2116492234 cites W2108348456 @default.
• W2116492234 cites W2109890918 @default.
• W2116492234 cites W2115235932 @default.
• W2116492234 cites W2119398594 @default.
• W2116492234 cites W2120425861 @default.
• W2116492234 cites W2122493628 @default.
• W2116492234 cites W2137665214 @default.
• W2116492234 cites W2139609470 @default.
• W2116492234 cites W2140922594 @default.
• W2116492234 cites W2143325804 @default.
• W2116492234 cites W2143416571 @default.
• W2116492234 cites W2145859343 @default.
• W2116492234 cites W2146259028 @default.
• W2116492234 cites W2148146668 @default.
• W2116492234 cites W2149694811 @default.
• W2116492234 cites W2151025332 @default.
• W2116492234 cites W2155462663 @default.
• W2116492234 cites W2157460441 @default.
• W2116492234 cites W2158102238 @default.
• W2116492234 cites W2168616898 @default.
• W2116492234 cites W4313371676 @default.
• W2116492234 doi "https://doi.org/10.1099/mic.0.29186-0" @default.
• W2116492234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17074912" @default.
• W2116492234 hasPublicationYear "2006" @default.
• W2116492234 type Work @default.
• W2116492234 sameAs 2116492234 @default.
• W2116492234 citedByCount "32" @default.
• W2116492234 countsByYear W21164922342012 @default.
• W2116492234 countsByYear W21164922342013 @default.
• W2116492234 countsByYear W21164922342014 @default.
• W2116492234 countsByYear W21164922342015 @default.
• W2116492234 countsByYear W21164922342016 @default.
• W2116492234 countsByYear W21164922342017 @default.
• W2116492234 countsByYear W21164922342019 @default.
• W2116492234 countsByYear W21164922342020 @default.
• W2116492234 countsByYear W21164922342021 @default.
• W2116492234 crossrefType "journal-article" @default.
• W2116492234 hasAuthorship W2116492234A5012728403 @default.
• W2116492234 hasAuthorship W2116492234A5029415610 @default.
• W2116492234 hasAuthorship W2116492234A5065680509 @default.
• W2116492234 hasAuthorship W2116492234A5073054776 @default.
• W2116492234 hasBestOaLocation W21164922341 @default.
• W2116492234 hasConcept C207332259 @default.
• W2116492234 hasConcept C2777576037 @default.
• W2116492234 hasConcept C2779222958 @default.

• next