FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116502500> ?p ?o ?g. }

• W2116502500 endingPage "5380" @default.
• W2116502500 startingPage "5373" @default.
• W2116502500 abstract "ABSTRACT Polyamines are required for optimal growth in most cells; however, polyamine accumulation leads to inhibition of cellular growth. To reduce intracellular polyamine levels, spermidine is monoacetylated in both prokaryotes and eukaryotes. In Escherichia coli , the speG gene encodes the spermidine acetyltransferase, which transfers the acetyl group to either the N-1 or N-8 position. In addition to polyamine accumulation, stress conditions, such as cold shock, cause an increase in the level of spermidine acetylation, suggesting an adaptive role for reduced polyamine levels under stressful growth conditions. The effect of spermidine accumulation on the growth of E. coli at low temperature was examined using a speG mutant. At 37°C, growth of the speG mutant was normal in the presence of 0.5 or 1 mM spermidine. However, following a shift to 7°C, the addition of 0.5 or 1 mM spermidine resulted in inhibition of cellular growth or cell lysis, respectively. Furthermore, at 7°C, spermidine accumulation resulted in a decrease in total protein synthesis accompanied by an increase in the synthesis of the major cold shock proteins CspA, CspB, and CspG. However, the addition of 50 mM Mg 2+ restored growth and protein synthesis in the presence of 0.5 mM spermidine. The results indicate that the level of spermidine acetylation increases at low temperature to prevent spermidine toxicity. The data suggest that the excess spermidine replaces the ribosome-bound Mg 2+ , resulting in ribosome inactivation at low temperatures." @default.
• W2116502500 created "2016-06-24" @default.
• W2116502500 creator A5050613154 @default.
• W2116502500 creator A5088741262 @default.
• W2116502500 date "2000-10-01" @default.
• W2116502500 modified "2023-09-27" @default.
• W2116502500 title "Spermidine Acetyltransferase Is Required To Prevent Spermidine Toxicity at Low Temperatures in <i>Escherichia coli</i>" @default.
• W2116502500 cites W117499605 @default.
• W2116502500 cites W126427411 @default.
• W2116502500 cites W1545905553 @default.
• W2116502500 cites W1606423922 @default.
• W2116502500 cites W1623420165 @default.
• W2116502500 cites W1756802921 @default.
• W2116502500 cites W1760910753 @default.
• W2116502500 cites W1783073205 @default.
• W2116502500 cites W1783564941 @default.
• W2116502500 cites W1866991149 @default.
• W2116502500 cites W1938045881 @default.
• W2116502500 cites W1964234588 @default.
• W2116502500 cites W1965802677 @default.
• W2116502500 cites W1966541226 @default.
• W2116502500 cites W1976156828 @default.
• W2116502500 cites W2003809891 @default.
• W2116502500 cites W2010672180 @default.
• W2116502500 cites W2014978187 @default.
• W2116502500 cites W2018306984 @default.
• W2116502500 cites W2032302915 @default.
• W2116502500 cites W2038962047 @default.
• W2116502500 cites W2060464569 @default.
• W2116502500 cites W2067257071 @default.
• W2116502500 cites W2093790363 @default.
• W2116502500 cites W2114813481 @default.
• W2116502500 cites W2116879291 @default.
• W2116502500 cites W2128547542 @default.
• W2116502500 cites W2132664565 @default.
• W2116502500 cites W2146464427 @default.
• W2116502500 cites W2199864774 @default.
• W2116502500 cites W2337025505 @default.
• W2116502500 cites W2411709383 @default.
• W2116502500 doi "https://doi.org/10.1128/jb.182.19.5373-5380.2000" @default.
• W2116502500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110979" @default.
• W2116502500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10986239" @default.
• W2116502500 hasPublicationYear "2000" @default.
• W2116502500 type Work @default.
• W2116502500 sameAs 2116502500 @default.
• W2116502500 citedByCount "51" @default.
• W2116502500 countsByYear W21165025002012 @default.
• W2116502500 countsByYear W21165025002013 @default.
• W2116502500 countsByYear W21165025002014 @default.
• W2116502500 countsByYear W21165025002015 @default.
• W2116502500 countsByYear W21165025002016 @default.
• W2116502500 countsByYear W21165025002017 @default.
• W2116502500 countsByYear W21165025002018 @default.
• W2116502500 countsByYear W21165025002019 @default.
• W2116502500 countsByYear W21165025002020 @default.
• W2116502500 countsByYear W21165025002021 @default.
• W2116502500 countsByYear W21165025002022 @default.
• W2116502500 crossrefType "journal-article" @default.
• W2116502500 hasAuthorship W2116502500A5050613154 @default.
• W2116502500 hasAuthorship W2116502500A5088741262 @default.
• W2116502500 hasBestOaLocation W21165025002 @default.
• W2116502500 hasConcept C104317684 @default.
• W2116502500 hasConcept C181199279 @default.
• W2116502500 hasConcept C2776109719 @default.
• W2116502500 hasConcept C2777167505 @default.
• W2116502500 hasConcept C2777497464 @default.
• W2116502500 hasConcept C2780115381 @default.
• W2116502500 hasConcept C2781188418 @default.
• W2116502500 hasConcept C547475151 @default.
• W2116502500 hasConcept C55493867 @default.
• W2116502500 hasConcept C86803240 @default.
• W2116502500 hasConceptScore W2116502500C104317684 @default.
• W2116502500 hasConceptScore W2116502500C181199279 @default.
• W2116502500 hasConceptScore W2116502500C2776109719 @default.
• W2116502500 hasConceptScore W2116502500C2777167505 @default.
• W2116502500 hasConceptScore W2116502500C2777497464 @default.
• W2116502500 hasConceptScore W2116502500C2780115381 @default.
• W2116502500 hasConceptScore W2116502500C2781188418 @default.
• W2116502500 hasConceptScore W2116502500C547475151 @default.
• W2116502500 hasConceptScore W2116502500C55493867 @default.
• W2116502500 hasConceptScore W2116502500C86803240 @default.
• W2116502500 hasIssue "19" @default.
• W2116502500 hasLocation W21165025001 @default.
• W2116502500 hasLocation W21165025002 @default.
• W2116502500 hasLocation W21165025003 @default.
• W2116502500 hasOpenAccess W2116502500 @default.
• W2116502500 hasPrimaryLocation W21165025001 @default.
• W2116502500 hasRelatedWork W1964857912 @default.
• W2116502500 hasRelatedWork W1965913407 @default.
• W2116502500 hasRelatedWork W2059631543 @default.
• W2116502500 hasRelatedWork W2082211825 @default.
• W2116502500 hasRelatedWork W2096098657 @default.
• W2116502500 hasRelatedWork W2168594241 @default.
• W2116502500 hasRelatedWork W2329027346 @default.
• W2116502500 hasRelatedWork W2414326766 @default.
• W2116502500 hasRelatedWork W2425524234 @default.
• W2116502500 hasRelatedWork W4250876040 @default.
• W2116502500 hasVolume "182" @default.

• next