Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116508030> ?p ?o ?g. }
- W2116508030 endingPage "732" @default.
- W2116508030 startingPage "727" @default.
- W2116508030 abstract "Exposure to solar ultraviolet (UV) B radiation is responsible for skin inflammation and tumour progression. Cyclooxygenase and ornithine decarboxylase are believed to be involved in such processes since they participate in the synthesis of mediators of inflammation and cell differentiation, respectively. We have investigated the in vitro modulation of expression of such genes by UVB radiation in different skin cell lines. We have observed that accumulation of ornithine decarboxylase mRNA is unaffected by even high UVB doses in both human epidermal keratinocytes and dermal fibroblasts, whereas cyclooxygenase-2 levels were significantly up-regulated by low UVB doses in KB human epidermoid keratinocytes. Depletion of total intracellular glutathione levels in KB cells amplified the activation, revealing a role for an oxidative component of UVB in modulating cyclooxygenase gene expression. Transfer of medium from UVB irradiated keratinocytes to fibroblasts resulted in a significant activation of cyclooxygenase expression and activity, while ornithine decarboxylase levels were unaffected. We conclude that UVB radiation can activate cyclooxygenase gene expression in human skin cells both by direct activation pathways or indirectly by inducing a paracrine mechanism." @default.
- W2116508030 created "2016-06-24" @default.
- W2116508030 creator A5048035985 @default.
- W2116508030 creator A5048867446 @default.
- W2116508030 creator A5088452240 @default.
- W2116508030 date "1999-04-01" @default.
- W2116508030 modified "2023-10-16" @default.
- W2116508030 title "Direct and indirect modulation of ornithine decarboxylase and cyclooxygenase by UVB radiation in human skin cells" @default.
- W2116508030 cites W1484515711 @default.
- W2116508030 cites W1591414362 @default.
- W2116508030 cites W1593319850 @default.
- W2116508030 cites W1969326413 @default.
- W2116508030 cites W1972735498 @default.
- W2116508030 cites W1974102428 @default.
- W2116508030 cites W1981278936 @default.
- W2116508030 cites W1982670887 @default.
- W2116508030 cites W1984969043 @default.
- W2116508030 cites W1999109761 @default.
- W2116508030 cites W1999158892 @default.
- W2116508030 cites W2004060206 @default.
- W2116508030 cites W2005075136 @default.
- W2116508030 cites W2010249684 @default.
- W2116508030 cites W2011613713 @default.
- W2116508030 cites W2020185180 @default.
- W2116508030 cites W2020828026 @default.
- W2116508030 cites W2023587041 @default.
- W2116508030 cites W2026114600 @default.
- W2116508030 cites W2029904549 @default.
- W2116508030 cites W2030847671 @default.
- W2116508030 cites W2033987263 @default.
- W2116508030 cites W2034544538 @default.
- W2116508030 cites W2035945839 @default.
- W2116508030 cites W2040528315 @default.
- W2116508030 cites W2047402537 @default.
- W2116508030 cites W2048604515 @default.
- W2116508030 cites W2049688520 @default.
- W2116508030 cites W2051691080 @default.
- W2116508030 cites W2059433877 @default.
- W2116508030 cites W2062893239 @default.
- W2116508030 cites W2064903623 @default.
- W2116508030 cites W2068659188 @default.
- W2116508030 cites W2069011333 @default.
- W2116508030 cites W2070386995 @default.
- W2116508030 cites W2079326005 @default.
- W2116508030 cites W2080535537 @default.
- W2116508030 cites W2087521596 @default.
- W2116508030 cites W2089923844 @default.
- W2116508030 cites W2101060955 @default.
- W2116508030 cites W2127223050 @default.
- W2116508030 cites W2132579331 @default.
- W2116508030 cites W2143464311 @default.
- W2116508030 cites W2149268447 @default.
- W2116508030 cites W2150289849 @default.
- W2116508030 cites W2330794658 @default.
- W2116508030 cites W2398921073 @default.
- W2116508030 cites W2460672531 @default.
- W2116508030 cites W61176855 @default.
- W2116508030 doi "https://doi.org/10.1093/carcin/20.4.727" @default.
- W2116508030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10223206" @default.
- W2116508030 hasPublicationYear "1999" @default.
- W2116508030 type Work @default.
- W2116508030 sameAs 2116508030 @default.
- W2116508030 citedByCount "28" @default.
- W2116508030 countsByYear W21165080302013 @default.
- W2116508030 countsByYear W21165080302015 @default.
- W2116508030 countsByYear W21165080302016 @default.
- W2116508030 crossrefType "journal-article" @default.
- W2116508030 hasAuthorship W2116508030A5048035985 @default.
- W2116508030 hasAuthorship W2116508030A5048867446 @default.
- W2116508030 hasAuthorship W2116508030A5088452240 @default.
- W2116508030 hasBestOaLocation W21165080301 @default.
- W2116508030 hasConcept C121289238 @default.
- W2116508030 hasConcept C153911025 @default.
- W2116508030 hasConcept C170493617 @default.
- W2116508030 hasConcept C181199279 @default.
- W2116508030 hasConcept C185592680 @default.
- W2116508030 hasConcept C202751555 @default.
- W2116508030 hasConcept C203014093 @default.
- W2116508030 hasConcept C2776914184 @default.
- W2116508030 hasConcept C2777074287 @default.
- W2116508030 hasConcept C2777459323 @default.
- W2116508030 hasConcept C2779689624 @default.
- W2116508030 hasConcept C502942594 @default.
- W2116508030 hasConcept C54355233 @default.
- W2116508030 hasConcept C55493867 @default.
- W2116508030 hasConcept C7876069 @default.
- W2116508030 hasConcept C81885089 @default.
- W2116508030 hasConcept C86803240 @default.
- W2116508030 hasConcept C95444343 @default.
- W2116508030 hasConceptScore W2116508030C121289238 @default.
- W2116508030 hasConceptScore W2116508030C153911025 @default.
- W2116508030 hasConceptScore W2116508030C170493617 @default.
- W2116508030 hasConceptScore W2116508030C181199279 @default.
- W2116508030 hasConceptScore W2116508030C185592680 @default.
- W2116508030 hasConceptScore W2116508030C202751555 @default.
- W2116508030 hasConceptScore W2116508030C203014093 @default.
- W2116508030 hasConceptScore W2116508030C2776914184 @default.
- W2116508030 hasConceptScore W2116508030C2777074287 @default.