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- W2116522650 abstract "Background: Identification of schizophrenia, a common neuropsychiatric disorder, is based on clinical examination. An easily measurable peripheral marker, which may enable a more rapid and more accurate diagnosis, is not available. A possible candidate is the D3 dopamine receptor on lymphocytes. Objective: The D3 receptor is investigated for its clinical significance as a marker for diagnosing schizophrenia. Methods: From eight schizophrenic patients and eight controls lymphocyte RNA was isolated. A semiquantitative reverse transcription–polymerase chain reaction (RT-PCR) was carried out and the intensities of the specific D3 dopamine receptor bands of patients and controls were compared. Results: No difference could be seen between the intensities of the bands from patients and controls. Conclusion: An aberrant D3 dopamine receptor mRNA expression in lymphocytes of schizophrenics could not be demonstrated. This might be caused by down-regulation of D3 receptor production by antipsychotic drug treatment. At present, the D3 receptor seems to have no diagnostic value in schizophrenia." @default.
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- W2116522650 date "2003-04-01" @default.
- W2116522650 modified "2023-09-27" @default.
- W2116522650 title "D3 dopamine receptor mRNA expression in lymphocytes: a peripheral marker for schizophrenia?" @default.
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- W2116522650 doi "https://doi.org/10.1034/j.1601-5215.2003.00010.x" @default.
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