Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116524808> ?p ?o ?g. }
- W2116524808 endingPage "44" @default.
- W2116524808 startingPage "40" @default.
- W2116524808 abstract "The present study was performed to evaluate the effects of two different phenolic antioxidants, resveratrol (3,5,4′-trihydroxystilbene) and butylated hydroxyanisole (BHA), on the hydrogen peroxide (H2O2)-induced inhibition of gap-junction intercellular communication (GJIC) in WB-F344 rat liver epithelial cells (WB-F344). Resveratrol is a naturally occurring polyphenolic antioxidant; on the other hand, BHA is a synthetic phenolic compound. We found that only resveratrol protects WB-F344 cells from H2O2-induced inhibition of GJIC, and BHA has no effect. The extracellular-signal-regulated protein kinase 1/2 (ERK1/2)–connexin 43 (Cx43) signaling pathway is crucial for the regulation of GJIC in rat liver epithelial cells, and resveratrol, but not BHA, blocked the H2O2-induced phosphorylation of Cx43, a critical regulator of GJIC, and ERK1/2 in WB-F344 cells. Resveratrol appears to attenuate the H2O2-mediated ERK1/2–Cx43 signaling pathway and consequently reverses H2O2-mediated inhibition of GJIC. DPPH and ABTS radical-scavenging assays revealed that the protective effect of resveratrol on the H2O2-mediated inhibition of GJIC was not mediated through its free radical-scavenging activity." @default.
- W2116524808 created "2016-06-24" @default.
- W2116524808 creator A5006050449 @default.
- W2116524808 creator A5034529941 @default.
- W2116524808 creator A5041792310 @default.
- W2116524808 creator A5072249558 @default.
- W2116524808 creator A5074519327 @default.
- W2116524808 creator A5081869913 @default.
- W2116524808 date "2009-12-01" @default.
- W2116524808 modified "2023-10-01" @default.
- W2116524808 title "Differential regulation of the hydrogen-peroxide-induced inhibition of gap-junction intercellular communication by resveratrol and butylated hydroxyanisole" @default.
- W2116524808 cites W168276155 @default.
- W2116524808 cites W1966989031 @default.
- W2116524808 cites W1973409609 @default.
- W2116524808 cites W1977845454 @default.
- W2116524808 cites W1984330114 @default.
- W2116524808 cites W1984373476 @default.
- W2116524808 cites W1996272414 @default.
- W2116524808 cites W1998029034 @default.
- W2116524808 cites W2008487276 @default.
- W2116524808 cites W2017560991 @default.
- W2116524808 cites W2031973329 @default.
- W2116524808 cites W2033215167 @default.
- W2116524808 cites W2039153442 @default.
- W2116524808 cites W2040839454 @default.
- W2116524808 cites W2045355966 @default.
- W2116524808 cites W2049094208 @default.
- W2116524808 cites W2052967261 @default.
- W2116524808 cites W2054107951 @default.
- W2116524808 cites W2056802141 @default.
- W2116524808 cites W2062887543 @default.
- W2116524808 cites W2065853716 @default.
- W2116524808 cites W2069035576 @default.
- W2116524808 cites W2075837927 @default.
- W2116524808 cites W2085670339 @default.
- W2116524808 cites W2090354143 @default.
- W2116524808 cites W2098594695 @default.
- W2116524808 cites W2099950974 @default.
- W2116524808 cites W2102472076 @default.
- W2116524808 cites W2120918947 @default.
- W2116524808 cites W2123929920 @default.
- W2116524808 cites W2142374820 @default.
- W2116524808 cites W2143267387 @default.
- W2116524808 cites W2154745788 @default.
- W2116524808 doi "https://doi.org/10.1016/j.mrfmmm.2009.08.011" @default.
- W2116524808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19720069" @default.
- W2116524808 hasPublicationYear "2009" @default.
- W2116524808 type Work @default.
- W2116524808 sameAs 2116524808 @default.
- W2116524808 citedByCount "13" @default.
- W2116524808 countsByYear W21165248082012 @default.
- W2116524808 countsByYear W21165248082013 @default.
- W2116524808 countsByYear W21165248082014 @default.
- W2116524808 countsByYear W21165248082015 @default.
- W2116524808 countsByYear W21165248082016 @default.
- W2116524808 countsByYear W21165248082021 @default.
- W2116524808 crossrefType "journal-article" @default.
- W2116524808 hasAuthorship W2116524808A5006050449 @default.
- W2116524808 hasAuthorship W2116524808A5034529941 @default.
- W2116524808 hasAuthorship W2116524808A5041792310 @default.
- W2116524808 hasAuthorship W2116524808A5072249558 @default.
- W2116524808 hasAuthorship W2116524808A5074519327 @default.
- W2116524808 hasAuthorship W2116524808A5081869913 @default.
- W2116524808 hasConcept C185592680 @default.
- W2116524808 hasConcept C2776816829 @default.
- W2116524808 hasConcept C2778004101 @default.
- W2116524808 hasConcept C2781418880 @default.
- W2116524808 hasConcept C28406088 @default.
- W2116524808 hasConcept C533411734 @default.
- W2116524808 hasConcept C55493867 @default.
- W2116524808 hasConcept C62478195 @default.
- W2116524808 hasConcept C79879829 @default.
- W2116524808 hasConcept C86803240 @default.
- W2116524808 hasConcept C95444343 @default.
- W2116524808 hasConceptScore W2116524808C185592680 @default.
- W2116524808 hasConceptScore W2116524808C2776816829 @default.
- W2116524808 hasConceptScore W2116524808C2778004101 @default.
- W2116524808 hasConceptScore W2116524808C2781418880 @default.
- W2116524808 hasConceptScore W2116524808C28406088 @default.
- W2116524808 hasConceptScore W2116524808C533411734 @default.
- W2116524808 hasConceptScore W2116524808C55493867 @default.
- W2116524808 hasConceptScore W2116524808C62478195 @default.
- W2116524808 hasConceptScore W2116524808C79879829 @default.
- W2116524808 hasConceptScore W2116524808C86803240 @default.
- W2116524808 hasConceptScore W2116524808C95444343 @default.
- W2116524808 hasIssue "1-2" @default.
- W2116524808 hasLocation W21165248081 @default.
- W2116524808 hasLocation W21165248082 @default.
- W2116524808 hasOpenAccess W2116524808 @default.
- W2116524808 hasPrimaryLocation W21165248081 @default.
- W2116524808 hasRelatedWork W1577673639 @default.
- W2116524808 hasRelatedWork W1974838099 @default.
- W2116524808 hasRelatedWork W2031910286 @default.
- W2116524808 hasRelatedWork W2471890020 @default.
- W2116524808 hasRelatedWork W2544406685 @default.
- W2116524808 hasRelatedWork W2586673537 @default.
- W2116524808 hasRelatedWork W2594973917 @default.
- W2116524808 hasRelatedWork W2797952716 @default.