Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116543144> ?p ?o ?g. }
- W2116543144 endingPage "1876" @default.
- W2116543144 startingPage "1863" @default.
- W2116543144 abstract "Aim: The objective of this study was to investigate the influence of the high-pressure homogenization (HPH) process and stabilizers on the physicochemical properties of glycerol monooleate (GMO)/chitosan nanostructures using curcumin as a model hydrophobic drug. Materials & methods: The oil-in-water nanoemulsion of the GMO/chitosan system was prepared by sonication and HPH techniques using two different stabilizers (polyvinyl alcohol [PVA] and poloxamer 407). The particle size (PS), ζ-potential (ZP) and physical stability of the nanoemulsion were investigated. These nanoemulsions were lyophilized and characterized for PS, ZP, surface morphology, moisture content and physical form of the drug in the nanostructures. The in vitro release and the uptake of curcumin in Caco-2 cells were evaluated using an ultra-performance liquid chromatography method. Results: Three cycles of HPH produced a 50–65% reduction in the PS of the nanoemulsion. A change in stabilizer, from PVA to poloxamer, did not affect the PS, physical stability, moisture content or the physical form of the drug in the formulation. However, there was a significant change in the ZP, surface morphology, in vitro release rate and cellular uptake from the two formulations. Conclusion: The process of HPH effectively reduces the PS of the GMO/chitosan nanoemulsions loaded with the hydrophobic drug. The type of stabilizer used affects several physicochemical properties of the GMO/chitosan nanostructures. Compared with PVA, poloxamer 407 is a more effective stabilizer for stabilizing the GMO/chitosan system containing a hydrophobic drug nanoemulsion at low concentrations. Original submitted 17 November 2011; Revised submitted 25 March 2012; Published online 18 June 2012" @default.
- W2116543144 created "2016-06-24" @default.
- W2116543144 creator A5025694157 @default.
- W2116543144 creator A5031761029 @default.
- W2116543144 creator A5061214773 @default.
- W2116543144 date "2012-12-01" @default.
- W2116543144 modified "2023-09-26" @default.
- W2116543144 title "Effect of high-pressure homogenization and stabilizers on the physicochemical properties of curcumin-loaded glycerol monooleate/chitosan nanostructures" @default.
- W2116543144 cites W1490299254 @default.
- W2116543144 cites W1664719478 @default.
- W2116543144 cites W1967716951 @default.
- W2116543144 cites W1969294750 @default.
- W2116543144 cites W1969604041 @default.
- W2116543144 cites W1975144520 @default.
- W2116543144 cites W1975770667 @default.
- W2116543144 cites W1976194786 @default.
- W2116543144 cites W1978876638 @default.
- W2116543144 cites W1987537515 @default.
- W2116543144 cites W1989828249 @default.
- W2116543144 cites W1992595116 @default.
- W2116543144 cites W1994520929 @default.
- W2116543144 cites W1996186923 @default.
- W2116543144 cites W1996822660 @default.
- W2116543144 cites W2000581595 @default.
- W2116543144 cites W2002430289 @default.
- W2116543144 cites W2018041818 @default.
- W2116543144 cites W2021124238 @default.
- W2116543144 cites W2025336062 @default.
- W2116543144 cites W2028244107 @default.
- W2116543144 cites W2037653676 @default.
- W2116543144 cites W2039602860 @default.
- W2116543144 cites W2051956152 @default.
- W2116543144 cites W2054189154 @default.
- W2116543144 cites W2072175441 @default.
- W2116543144 cites W2073990224 @default.
- W2116543144 cites W2074907280 @default.
- W2116543144 cites W2081337060 @default.
- W2116543144 cites W2082125216 @default.
- W2116543144 cites W2084472233 @default.
- W2116543144 cites W2087012501 @default.
- W2116543144 cites W2089531507 @default.
- W2116543144 cites W2093999917 @default.
- W2116543144 cites W2098329282 @default.
- W2116543144 cites W211065809 @default.
- W2116543144 cites W2115586774 @default.
- W2116543144 cites W2117630026 @default.
- W2116543144 cites W2139383246 @default.
- W2116543144 cites W2144942817 @default.
- W2116543144 cites W2163121468 @default.
- W2116543144 cites W2164738701 @default.
- W2116543144 cites W344335130 @default.
- W2116543144 cites W4251505294 @default.
- W2116543144 cites W4376849571 @default.
- W2116543144 cites W2095732828 @default.
- W2116543144 doi "https://doi.org/10.2217/nnm.12.49" @default.
- W2116543144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22709346" @default.
- W2116543144 hasPublicationYear "2012" @default.
- W2116543144 type Work @default.
- W2116543144 sameAs 2116543144 @default.
- W2116543144 citedByCount "24" @default.
- W2116543144 countsByYear W21165431442013 @default.
- W2116543144 countsByYear W21165431442014 @default.
- W2116543144 countsByYear W21165431442015 @default.
- W2116543144 countsByYear W21165431442016 @default.
- W2116543144 countsByYear W21165431442017 @default.
- W2116543144 countsByYear W21165431442018 @default.
- W2116543144 countsByYear W21165431442019 @default.
- W2116543144 countsByYear W21165431442020 @default.
- W2116543144 countsByYear W21165431442021 @default.
- W2116543144 countsByYear W21165431442022 @default.
- W2116543144 countsByYear W21165431442023 @default.
- W2116543144 crossrefType "journal-article" @default.
- W2116543144 hasAuthorship W2116543144A5025694157 @default.
- W2116543144 hasAuthorship W2116543144A5031761029 @default.
- W2116543144 hasAuthorship W2116543144A5061214773 @default.
- W2116543144 hasConcept C101335993 @default.
- W2116543144 hasConcept C104628117 @default.
- W2116543144 hasConcept C127413603 @default.
- W2116543144 hasConcept C15920480 @default.
- W2116543144 hasConcept C178790620 @default.
- W2116543144 hasConcept C185592680 @default.
- W2116543144 hasConcept C192562407 @default.
- W2116543144 hasConcept C2777502316 @default.
- W2116543144 hasConcept C2778250585 @default.
- W2116543144 hasConcept C2778551929 @default.
- W2116543144 hasConcept C2779732960 @default.
- W2116543144 hasConcept C2780306666 @default.
- W2116543144 hasConcept C2780881558 @default.
- W2116543144 hasConcept C42360764 @default.
- W2116543144 hasConcept C43617362 @default.
- W2116543144 hasConcept C521977710 @default.
- W2116543144 hasConcept C55493867 @default.
- W2116543144 hasConcept C78519656 @default.
- W2116543144 hasConceptScore W2116543144C101335993 @default.
- W2116543144 hasConceptScore W2116543144C104628117 @default.
- W2116543144 hasConceptScore W2116543144C127413603 @default.
- W2116543144 hasConceptScore W2116543144C15920480 @default.
- W2116543144 hasConceptScore W2116543144C178790620 @default.