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- W2116559137 endingPage "3787" @default.
- W2116559137 startingPage "3776" @default.
- W2116559137 abstract "Antitrypsin deficiency is a primary cause of juvenile liver disease, and it arises from expression of the “Z” variant of the α-1 protease inhibitor (A1Pi). Whereas A1Pi is secreted from the liver, A1PiZ is retrotranslocated from the endoplasmic reticulum (ER) and degraded by the proteasome, an event that may offset liver damage. To better define the mechanism of A1PiZ degradation, a yeast expression system was developed previously, and a gene, ADD66, was identified that facilitates A1PiZ turnover. We report here that ADD66 encodes an ∼30-kDa soluble, cytosolic protein and that the chymotrypsin-like activity of the proteasome is reduced in add66Δ mutants. This reduction in activity may arise from the accumulation of 20S proteasome assembly intermediates or from qualitative differences in assembled proteasomes. Add66p also seems to be a proteasome substrate. Consistent with its role in ER-associated degradation (ERAD), synthetic interactions are observed between the genes encoding Add66p and Ire1p, a transducer of the unfolded protein response, and yeast deleted for both ADD66 and/or IRE1 accumulate polyubiquitinated proteins. These data identify Add66p as a proteasome assembly chaperone (PAC), and they provide the first link between PAC activity and ERAD." @default.
- W2116559137 created "2016-06-24" @default.
- W2116559137 creator A5004896108 @default.
- W2116559137 creator A5044222068 @default.
- W2116559137 creator A5049362329 @default.
- W2116559137 creator A5065387428 @default.
- W2116559137 creator A5076983691 @default.
- W2116559137 creator A5078488780 @default.
- W2116559137 date "2007-10-01" @default.
- W2116559137 modified "2023-10-15" @default.
- W2116559137 title "<i>ADD66</i>, a Gene Involved in the Endoplasmic Reticulum-associated Degradation of α-1-Antitrypsin-Z in Yeast, Facilitates Proteasome Activity and Assembly" @default.
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