FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116567360> ?p ?o ?g. }

• W2116567360 endingPage "816" @default.
• W2116567360 startingPage "812" @default.
• W2116567360 abstract "Gentamicin, tobramycin, and netilmicin were given to rats in daily doses of either 5 or 20 mg/kg for 30 days to determine the renal accumulation kinetics of the compounds and to correlate steady-state renal parenchymal concentrations with nephrotoxicity. Four rats from each group were sacrificed daily and renal parenchymal tissue concentrations were determined microbiologically. Nephrotoxicity was assessed by changes in creatinine values in serum, renal creatinine clearances, and pathological scores. There was no indication of aminoglycoside-induced nephrotoxicity in any tests performed. The following steady-state levels resulted: 36, 148, and 176 micrograms/g after 5 mg/kg per day and 148, 260, and 510 micrograms/g after 20 mg/kg per day for tobramycin, gentamicin, and netilmicin, respectively. We conclude that aminoglycoside parenchymal accumulation in rats follows this order: tobramycin less than gentamicin less than netilmicin. Therefore, differences in the relative toxicities of gentamicin, tobramycin, and netilmicin do not correlate with the renal parenchymal accumulation of these agents and may be more dependent on intrinsic toxicity to the renal proximal tubule than to the concentration of the aminoglycoside in the kidney." @default.
• W2116567360 created "2016-06-24" @default.
• W2116567360 creator A5004223984 @default.
• W2116567360 creator A5009104393 @default.
• W2116567360 creator A5031129081 @default.
• W2116567360 creator A5055069562 @default.
• W2116567360 creator A5056794023 @default.
• W2116567360 creator A5060001237 @default.
• W2116567360 date "1985-05-01" @default.
• W2116567360 modified "2023-09-27" @default.
• W2116567360 title "Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities" @default.
• W2116567360 cites W2001156991 @default.
• W2116567360 cites W2014263385 @default.
• W2116567360 cites W2020857286 @default.
• W2116567360 cites W2022433962 @default.
• W2116567360 cites W2030794220 @default.
• W2116567360 cites W2037974456 @default.
• W2116567360 cites W2049017829 @default.
• W2116567360 cites W2078873770 @default.
• W2116567360 cites W2081809949 @default.
• W2116567360 cites W2082148491 @default.
• W2116567360 cites W2239480999 @default.
• W2116567360 cites W2316786951 @default.
• W2116567360 cites W2502670554 @default.
• W2116567360 doi "https://doi.org/10.1128/aac.27.5.812" @default.
• W2116567360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/180157" @default.
• W2116567360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4015072" @default.
• W2116567360 hasPublicationYear "1985" @default.
• W2116567360 type Work @default.
• W2116567360 sameAs 2116567360 @default.
• W2116567360 citedByCount "27" @default.
• W2116567360 crossrefType "journal-article" @default.
• W2116567360 hasAuthorship W2116567360A5004223984 @default.
• W2116567360 hasAuthorship W2116567360A5009104393 @default.
• W2116567360 hasAuthorship W2116567360A5031129081 @default.
• W2116567360 hasAuthorship W2116567360A5055069562 @default.
• W2116567360 hasAuthorship W2116567360A5056794023 @default.
• W2116567360 hasAuthorship W2116567360A5060001237 @default.
• W2116567360 hasBestOaLocation W21165673602 @default.
• W2116567360 hasConcept C126189478 @default.
• W2116567360 hasConcept C126322002 @default.
• W2116567360 hasConcept C134018914 @default.
• W2116567360 hasConcept C185592680 @default.
• W2116567360 hasConcept C2775832221 @default.
• W2116567360 hasConcept C2777787772 @default.
• W2116567360 hasConcept C2778974779 @default.
• W2116567360 hasConcept C2778977604 @default.
• W2116567360 hasConcept C2780091579 @default.
• W2116567360 hasConcept C2780306776 @default.
• W2116567360 hasConcept C3019249092 @default.
• W2116567360 hasConcept C501593827 @default.
• W2116567360 hasConcept C55493867 @default.
• W2116567360 hasConcept C71924100 @default.
• W2116567360 hasConcept C98274493 @default.
• W2116567360 hasConceptScore W2116567360C126189478 @default.
• W2116567360 hasConceptScore W2116567360C126322002 @default.
• W2116567360 hasConceptScore W2116567360C134018914 @default.
• W2116567360 hasConceptScore W2116567360C185592680 @default.
• W2116567360 hasConceptScore W2116567360C2775832221 @default.
• W2116567360 hasConceptScore W2116567360C2777787772 @default.
• W2116567360 hasConceptScore W2116567360C2778974779 @default.
• W2116567360 hasConceptScore W2116567360C2778977604 @default.
• W2116567360 hasConceptScore W2116567360C2780091579 @default.
• W2116567360 hasConceptScore W2116567360C2780306776 @default.
• W2116567360 hasConceptScore W2116567360C3019249092 @default.
• W2116567360 hasConceptScore W2116567360C501593827 @default.
• W2116567360 hasConceptScore W2116567360C55493867 @default.
• W2116567360 hasConceptScore W2116567360C71924100 @default.
• W2116567360 hasConceptScore W2116567360C98274493 @default.
• W2116567360 hasIssue "5" @default.
• W2116567360 hasLocation W21165673601 @default.
• W2116567360 hasLocation W21165673602 @default.
• W2116567360 hasOpenAccess W2116567360 @default.
• W2116567360 hasPrimaryLocation W21165673601 @default.
• W2116567360 hasRelatedWork W1542315482 @default.
• W2116567360 hasRelatedWork W1980978727 @default.
• W2116567360 hasRelatedWork W1981375683 @default.
• W2116567360 hasRelatedWork W2000307487 @default.
• W2116567360 hasRelatedWork W2001156991 @default.
• W2116567360 hasRelatedWork W2024873143 @default.
• W2116567360 hasRelatedWork W2025311696 @default.
• W2116567360 hasRelatedWork W2025541127 @default.
• W2116567360 hasRelatedWork W2033407849 @default.
• W2116567360 hasRelatedWork W2034973653 @default.
• W2116567360 hasRelatedWork W2037019082 @default.
• W2116567360 hasRelatedWork W2078873770 @default.
• W2116567360 hasRelatedWork W2081809949 @default.
• W2116567360 hasRelatedWork W2082148491 @default.
• W2116567360 hasRelatedWork W2107037237 @default.
• W2116567360 hasRelatedWork W2170602390 @default.
• W2116567360 hasRelatedWork W2265479341 @default.
• W2116567360 hasRelatedWork W2405335964 @default.
• W2116567360 hasRelatedWork W2405575544 @default.
• W2116567360 hasRelatedWork W2426600488 @default.
• W2116567360 hasVolume "27" @default.
• W2116567360 isParatext "false" @default.
• W2116567360 isRetracted "false" @default.
• W2116567360 magId "2116567360" @default.

• next