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• W2116572093 abstract "Using a model of recreational cocaine consumption, we have determined in four rhesus monkeys the impact of self-administered cocaine on mesolimbic and sensorimotor striatal dopaminergic neurotransmission. The effects of cocaine repeated within a self-administration session and across multiple sessions over a 6 month period were determined by the use of fixed-ratio self-administration and microdialysis procedures. The exposure to cocaine was modest, with at most two 0.5 mg/kg infusions permitted in each weekly session. Within a cocaine self-administration session, acute tolerance to the ability of cocaine to elevate extracellular striatal dopamine was observed. Over a period of 6 months of repeated self-administration, there was a significant increase in the impact of a fixed dose on extracellular dopamine, indicating that neurochemical sensitization to the effects of self-administered cocaine occurs in primates. A pronounced dopaminergic response to noncontingent cocaine was also observed, with no increases in extracellular dopamine in response to an unexpected saline substitution, indicating that the neurochemical response to self-administered cocaine is primarily caused by direct pharmacological effects of the drug rather than by conditioning to external environmental cues. These results highlight the contrast in time-dependent changes in neurochemical responsiveness to cocaine, depending on whether within-session or between-session comparisons are made. They also demonstrate that recreational levels of cocaine consumption can result in neurochemical sensitization, an enduring change in brain function that may contribute to addiction." @default.
• W2116572093 created "2016-06-24" @default.
• W2116572093 creator A5044961426 @default.
• W2116572093 date "2000-09-15" @default.
• W2116572093 modified "2023-10-18" @default.
• W2116572093 title "Acute and Chronic Dopamine Dynamics in a Nonhuman Primate Model of Recreational Cocaine Use" @default.
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• W2116572093 doi "https://doi.org/10.1523/jneurosci.20-18-07109.2000" @default.
• W2116572093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6772809" @default.
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