FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116572099> ?p ?o ?g. }

• W2116572099 endingPage "9" @default.
• W2116572099 startingPage "1" @default.
• W2116572099 abstract "Gossypol is a phenolic aldehyde extracted from plants and is known to be an antitumor agent to induce cancer cell apoptosis. In the present study, multiple myeloma cells were treated with gossypol, which resulted in an increase of cellular reactive oxygen species (ROS) and cell necrosis. Quantitative proteomic analysis was carried out to identify differentially expressed proteins between untreated and gossypol-treated cells. Proteomic analysis identified 4330 proteins, in which 202 proteins are upregulated and 383 proteins are downregulated in gossypol-treated cells as compared to the untreated cells. Importantly, proteomic and western blot analysis showed that apoptosis regulators BAK and Bax were upregulated in gossypol-treated cells, indicating that Bcl-2 associated death pathway was activated. Similarly, gossypol also induced upregulations of DNA mismatch repair proteins and DNA replication licensing factor, suggesting that gossypol caused significant DNA damage. Furthermore, upregulations of HLA class I and class II histocompatibility antigens and beta-2-microglobulin were observed in gossypol-treated cells, indicating that gossypol has a novel function to activate cellular immune responses. Our data demonstrate that the execution of necrosis is a complex process involving ROS, DNA damage, and Bcl-2 family proteins. Gossypol-activated immune responses are a potential new approach for multiple myeloma chemotherapy." @default.
• W2116572099 created "2016-06-24" @default.
• W2116572099 creator A5002087255 @default.
• W2116572099 creator A5007942235 @default.
• W2116572099 creator A5032927275 @default.
• W2116572099 creator A5085262519 @default.
• W2116572099 creator A5087777350 @default.
• W2116572099 date "2014-01-01" @default.
• W2116572099 modified "2023-09-30" @default.
• W2116572099 title "Proteomic Analysis of Gossypol Induces Necrosis in Multiple Myeloma Cells" @default.
• W2116572099 cites W1556723959 @default.
• W2116572099 cites W1964182229 @default.
• W2116572099 cites W1972779889 @default.
• W2116572099 cites W1973562447 @default.
• W2116572099 cites W1980727670 @default.
• W2116572099 cites W1981424043 @default.
• W2116572099 cites W1995246165 @default.
• W2116572099 cites W2016266035 @default.
• W2116572099 cites W2028330103 @default.
• W2116572099 cites W2031549500 @default.
• W2116572099 cites W2038009564 @default.
• W2116572099 cites W2039251470 @default.
• W2116572099 cites W2041902986 @default.
• W2116572099 cites W2043946038 @default.
• W2116572099 cites W2052802991 @default.
• W2116572099 cites W2057693225 @default.
• W2116572099 cites W2058162992 @default.
• W2116572099 cites W2063936308 @default.
• W2116572099 cites W2077364468 @default.
• W2116572099 cites W2077993954 @default.
• W2116572099 cites W2082530208 @default.
• W2116572099 cites W2092993410 @default.
• W2116572099 cites W2095281683 @default.
• W2116572099 cites W2101035019 @default.
• W2116572099 cites W2106917466 @default.
• W2116572099 cites W2107843774 @default.
• W2116572099 cites W2109261996 @default.
• W2116572099 cites W2111945749 @default.
• W2116572099 cites W2115772647 @default.
• W2116572099 cites W2116786011 @default.
• W2116572099 cites W2120680386 @default.
• W2116572099 cites W2124660181 @default.
• W2116572099 cites W2127009065 @default.
• W2116572099 cites W2129529988 @default.
• W2116572099 cites W2129778797 @default.
• W2116572099 cites W2133669258 @default.
• W2116572099 cites W2137878070 @default.
• W2116572099 cites W2144249875 @default.
• W2116572099 cites W2146483998 @default.
• W2116572099 cites W2159190959 @default.
• W2116572099 cites W2159299633 @default.
• W2116572099 cites W2161149476 @default.
• W2116572099 cites W2162594402 @default.
• W2116572099 cites W2167007275 @default.
• W2116572099 cites W2169916475 @default.
• W2116572099 cites W2171209671 @default.
• W2116572099 cites W2609515889 @default.
• W2116572099 cites W4252175385 @default.
• W2116572099 doi "https://doi.org/10.1155/2014/839232" @default.
• W2116572099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4150408" @default.
• W2116572099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25197664" @default.
• W2116572099 hasPublicationYear "2014" @default.
• W2116572099 type Work @default.
• W2116572099 sameAs 2116572099 @default.
• W2116572099 citedByCount "9" @default.
• W2116572099 countsByYear W21165720992015 @default.
• W2116572099 countsByYear W21165720992016 @default.
• W2116572099 countsByYear W21165720992017 @default.
• W2116572099 countsByYear W21165720992018 @default.
• W2116572099 countsByYear W21165720992020 @default.
• W2116572099 countsByYear W21165720992021 @default.
• W2116572099 countsByYear W21165720992023 @default.
• W2116572099 crossrefType "journal-article" @default.
• W2116572099 hasAuthorship W2116572099A5002087255 @default.
• W2116572099 hasAuthorship W2116572099A5007942235 @default.
• W2116572099 hasAuthorship W2116572099A5032927275 @default.
• W2116572099 hasAuthorship W2116572099A5085262519 @default.
• W2116572099 hasAuthorship W2116572099A5087777350 @default.
• W2116572099 hasBestOaLocation W21165720991 @default.
• W2116572099 hasConcept C104317684 @default.
• W2116572099 hasConcept C143425029 @default.
• W2116572099 hasConcept C153911025 @default.
• W2116572099 hasConcept C17991360 @default.
• W2116572099 hasConcept C185592680 @default.
• W2116572099 hasConcept C190283241 @default.
• W2116572099 hasConcept C203014093 @default.
• W2116572099 hasConcept C2776415932 @default.
• W2116572099 hasConcept C2776653637 @default.
• W2116572099 hasConcept C31573885 @default.
• W2116572099 hasConcept C552990157 @default.
• W2116572099 hasConcept C55493867 @default.
• W2116572099 hasConcept C86803240 @default.
• W2116572099 hasConcept C8891405 @default.
• W2116572099 hasConcept C95444343 @default.
• W2116572099 hasConceptScore W2116572099C104317684 @default.
• W2116572099 hasConceptScore W2116572099C143425029 @default.
• W2116572099 hasConceptScore W2116572099C153911025 @default.
• W2116572099 hasConceptScore W2116572099C17991360 @default.

• next