Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116581628> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2116581628 endingPage "1372" @default.
- W2116581628 startingPage "1363" @default.
- W2116581628 abstract "In 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he termed “torsades de pointes” (TdP).w1 w2 The word “torsades” refers to an ornamental motif imitating twisted hairs or threads as seen on classical architectural columns, and “pointes” referred to points or peaks.w1 w2 In the seminal article, Dessertenne made no attempt to suggest the mechanism of TdP and, until recently, there has been considerable conjecture as to the pathophysiology of this arrhythmia.Since the original work by Dessertenne, it has been well recognised that many conditions may cause prolonged or abnormal repolarisation (that is, QT interval prolongation and/or abnormal T or T/U wave morphology), which is associated with TdP. If TdP is rapid or prolonged, it can lead to ventricular fibrillation and sudden cardiac death (fig 1). Essentially, TdP may be caused by either congenital or acquired long QT syndrome (LQTS). In recent years, there has been considerable renewed interest in the assessment and understanding of ventricular repolarisation and TdP. There are several reasons for this. Firstly, the cloning of cardiac ion channels has improved the understanding of the role of ionic channels in mediating cardiac repolarisation, the pathophysiological mechanism of LQTS (congenital and acquired forms), and the pathogenesis of TdP. Secondly, modern molecular techniques have unravelled the mutations in genes encoding cardiac ion channels that cause long QT syndrome, although the genetic defects in about 50% of patients are still unknown. Thirdly, there has been considerable enthusiasm for the development and use of class III antiarrhythmic drugs, which prolong repolarisation and cardiac refractoriness. Unfortunately, drugs that alter repolarisation have now been recognised to increase the propensity for TdP. Finally, an increasing number of drugs, especially non-cardiac drugs, have been recognised to delay cardiac repolarisation and to share the ability with class III …" @default.
- W2116581628 created "2016-06-24" @default.
- W2116581628 creator A5003153735 @default.
- W2116581628 creator A5040480141 @default.
- W2116581628 date "2003-11-01" @default.
- W2116581628 modified "2023-10-12" @default.
- W2116581628 title "Drug induced QT prolongation and torsades de pointes" @default.
- W2116581628 cites W1606576717 @default.
- W2116581628 cites W1896670469 @default.
- W2116581628 cites W1980240868 @default.
- W2116581628 cites W1997088191 @default.
- W2116581628 cites W2000810380 @default.
- W2116581628 cites W2007599742 @default.
- W2116581628 cites W2032435536 @default.
- W2116581628 cites W2043806071 @default.
- W2116581628 cites W2063122799 @default.
- W2116581628 cites W2093519496 @default.
- W2116581628 cites W2115629122 @default.
- W2116581628 cites W2140519222 @default.
- W2116581628 cites W2145142280 @default.
- W2116581628 cites W2151291519 @default.
- W2116581628 cites W2153296766 @default.
- W2116581628 doi "https://doi.org/10.1136/heart.89.11.1363" @default.
- W2116581628 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1767957" @default.
- W2116581628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14594906" @default.
- W2116581628 hasPublicationYear "2003" @default.
- W2116581628 type Work @default.
- W2116581628 sameAs 2116581628 @default.
- W2116581628 citedByCount "819" @default.
- W2116581628 countsByYear W21165816282012 @default.
- W2116581628 countsByYear W21165816282013 @default.
- W2116581628 countsByYear W21165816282014 @default.
- W2116581628 countsByYear W21165816282015 @default.
- W2116581628 countsByYear W21165816282016 @default.
- W2116581628 countsByYear W21165816282017 @default.
- W2116581628 countsByYear W21165816282018 @default.
- W2116581628 countsByYear W21165816282019 @default.
- W2116581628 countsByYear W21165816282020 @default.
- W2116581628 countsByYear W21165816282021 @default.
- W2116581628 countsByYear W21165816282022 @default.
- W2116581628 countsByYear W21165816282023 @default.
- W2116581628 crossrefType "journal-article" @default.
- W2116581628 hasAuthorship W2116581628A5003153735 @default.
- W2116581628 hasAuthorship W2116581628A5040480141 @default.
- W2116581628 hasBestOaLocation W21165816281 @default.
- W2116581628 hasConcept C118441451 @default.
- W2116581628 hasConcept C126322002 @default.
- W2116581628 hasConcept C164705383 @default.
- W2116581628 hasConcept C2777672339 @default.
- W2116581628 hasConcept C2779703243 @default.
- W2116581628 hasConcept C2780035454 @default.
- W2116581628 hasConcept C2780486423 @default.
- W2116581628 hasConcept C71924100 @default.
- W2116581628 hasConcept C98274493 @default.
- W2116581628 hasConceptScore W2116581628C118441451 @default.
- W2116581628 hasConceptScore W2116581628C126322002 @default.
- W2116581628 hasConceptScore W2116581628C164705383 @default.
- W2116581628 hasConceptScore W2116581628C2777672339 @default.
- W2116581628 hasConceptScore W2116581628C2779703243 @default.
- W2116581628 hasConceptScore W2116581628C2780035454 @default.
- W2116581628 hasConceptScore W2116581628C2780486423 @default.
- W2116581628 hasConceptScore W2116581628C71924100 @default.
- W2116581628 hasConceptScore W2116581628C98274493 @default.
- W2116581628 hasIssue "11" @default.
- W2116581628 hasLocation W21165816281 @default.
- W2116581628 hasLocation W21165816282 @default.
- W2116581628 hasLocation W21165816283 @default.
- W2116581628 hasLocation W21165816284 @default.
- W2116581628 hasOpenAccess W2116581628 @default.
- W2116581628 hasPrimaryLocation W21165816281 @default.
- W2116581628 hasRelatedWork W1977681502 @default.
- W2116581628 hasRelatedWork W2028521745 @default.
- W2116581628 hasRelatedWork W2104364676 @default.
- W2116581628 hasRelatedWork W2171718799 @default.
- W2116581628 hasRelatedWork W2341385452 @default.
- W2116581628 hasRelatedWork W2555634034 @default.
- W2116581628 hasRelatedWork W3094909023 @default.
- W2116581628 hasRelatedWork W3110574997 @default.
- W2116581628 hasRelatedWork W4307172607 @default.
- W2116581628 hasRelatedWork W624239607 @default.
- W2116581628 hasVolume "89" @default.
- W2116581628 isParatext "false" @default.
- W2116581628 isRetracted "false" @default.
- W2116581628 magId "2116581628" @default.
- W2116581628 workType "article" @default.