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- W2116601617 endingPage "159" @default.
- W2116601617 startingPage "145" @default.
- W2116601617 abstract "The most efficient drugs to alleviate severe pain are opioid compounds. However, their chronic use could be associated with serious drawbacks, such as tolerance, respiratory depression and constipation. Therefore, there is a need for compounds able to efficiently alleviate inflammatory and neurogenic pain following chronic treatment. The discovery that the endogenous opioid peptides, enkephalins, are inactivated by two metallopeptidases, neutral endopeptidase and aminopeptidase N, which can be blocked by synthetic dual inhibitors, represents a promising way to develop ‘physiological’ analgesics devoid of morphine side effects. These dual inhibitors also have antidepressant-like properties through enkephalin-related activation of δ-opioid receptors. This is expected to reduce the emotional component of pain in humans. This article reviews the promising data obtained for future development of a new class of analgesic that could be of major interest in a number of severe and chronic pain syndromes." @default.
- W2116601617 created "2016-06-24" @default.
- W2116601617 creator A5032132304 @default.
- W2116601617 creator A5077955988 @default.
- W2116601617 date "2007-01-17" @default.
- W2116601617 modified "2023-09-27" @default.
- W2116601617 title "Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs" @default.
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