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• W2116601957 abstract "In a presynaptic nerve terminal, synaptic vesicle exocytosis is restricted to specialized sites called active zones. At these sites, neurotransmitter release is determined by the number of releasable vesicles and their probability of release. Proteins at the active zone set these parameters by controlling the presynaptic Ca(2+) signal, and through docking and priming of synaptic vesicles. Vertebrate ELKS proteins are enriched at presynaptic active zones, but their functions are not well understood. ELKS proteins are produced by two genes in vertebrates, and each gene contributes ∼50% to total brain ELKS. We generated knock-out mice for ELKS1 and found that its constitutive removal causes lethality. To bypass lethality, and to circumvent redundancy between ELKS1 and ELKS2 in synaptic transmission, we used a conditional genetic approach to remove both genes in cultured hippocampal neurons after synapses are established. Simultaneous removal of ELKS1 and ELKS2 resulted in a 50% decrease of neurotransmitter release at inhibitory synapses, paralleled by a reduction in release probability. Removal of ELKS did not affect synapse numbers or their electron microscopic appearance. Using Ca(2+) imaging, we found that loss of ELKS caused a 30% reduction in single action potential-triggered Ca(2+) influx in inhibitory nerve terminals, consistent with the deficits in synaptic transmission and release probability. Unlike deletion of the active zone proteins RIM, RIM-BP, or bruchpilot, ELKS removal did not lead to a measurable reduction in presynaptic Ca(2+) channel levels. Our results reveal that ELKS is required for normal Ca(2+) influx at nerve terminals of inhibitory hippocampal neurons." @default.
• W2116601957 created "2016-06-24" @default.
• W2116601957 creator A5016526043 @default.
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• W2116601957 date "2014-09-10" @default.
• W2116601957 modified "2023-09-26" @default.
• W2116601957 title "The Active Zone Protein Family ELKS Supports Ca²⁺Influx at Nerve Terminals of Inhibitory Hippocampal Neurons" @default.
• W2116601957 cites W1618714882 @default.
• W2116601957 cites W1622207681 @default.
• W2116601957 cites W1807494075 @default.
• W2116601957 cites W1964189494 @default.
• W2116601957 cites W1971075145 @default.
• W2116601957 cites W1973841770 @default.
• W2116601957 cites W1974020471 @default.
• W2116601957 cites W1974311316 @default.
• W2116601957 cites W1974747739 @default.
• W2116601957 cites W1975923899 @default.
• W2116601957 cites W1979014198 @default.
• W2116601957 cites W1999369847 @default.
• W2116601957 cites W2004077897 @default.
• W2116601957 cites W2006184695 @default.
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• W2116601957 cites W2015752601 @default.
• W2116601957 cites W2016518770 @default.
• W2116601957 cites W2016812630 @default.
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• W2116601957 cites W2025214550 @default.
• W2116601957 cites W2027014007 @default.
• W2116601957 cites W2029142270 @default.
• W2116601957 cites W2029712139 @default.
• W2116601957 cites W2030094319 @default.
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• W2116601957 cites W2064575171 @default.
• W2116601957 cites W2065619689 @default.
• W2116601957 cites W2067481095 @default.
• W2116601957 cites W2068420002 @default.
• W2116601957 cites W2076227043 @default.
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• W2116601957 doi "https://doi.org/10.1523/jneurosci.0999-14.2014" @default.
• W2116601957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4160768" @default.
• W2116601957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25209271" @default.
• W2116601957 hasPublicationYear "2014" @default.
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