FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116604558> ?p ?o ?g. }

• W2116604558 endingPage "2589" @default.
• W2116604558 startingPage "2585" @default.
• W2116604558 abstract "Among the factors modulating transplant rejection and cardiovascular disease, chemokines and their respective receptors deserve special attention. In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease. The impact of the MCP-1-2518G and CCR2-64I genotypes on renal allograft function was investigated in 232 patients who underwent transplantation over an 11-yr period. Genomic DNA was genotyped using PCR with sequence-specific primers followed by restriction fragment length polymorphism analysis. Eighteen (7.8%) patients were homozygous for the MCP-1-2518G mutation. The G/G allele of MCP-1 -2518 behaved as a determinant for long-term allograft survival and resulted in reduction of the mean graft survival, as compared with the heterozygous (A/G) or wild-type (A/A) allele (67 +/- 14 versus 95 +/- 4 mo; Log rank P = 0.0052). The 64I mutation of CCR2 had no effect on kidney graft failure (93 +/- 6 and 91 +/- 5 mo, respectively; P = 0.81). None of the investigated polymorphisms showed a significant shift in gene frequency in acute rejection and rejection-free groups. In conjunction with these findings, peripheral blood mononuclear cells from kidney transplant recipients carrying the G-allele were characterized by a 2.5-fold higher MCP-1 secretion (P < 0.05). In conclusion, recipients of renal transplants homozygous for the -2518 G mutation of the MCP-1 gene are at risk for premature kidney graft failure. This variant of MCP-1 may be a future predictor for long-term kidney graft failure." @default.
• W2116604558 created "2016-06-24" @default.
• W2116604558 creator A5000738249 @default.
• W2116604558 creator A5006009691 @default.
• W2116604558 creator A5012021516 @default.
• W2116604558 creator A5014537121 @default.
• W2116604558 creator A5015465551 @default.
• W2116604558 creator A5027429186 @default.
• W2116604558 creator A5075653724 @default.
• W2116604558 creator A5079705894 @default.
• W2116604558 date "2002-10-01" @default.
• W2116604558 modified "2023-10-18" @default.
• W2116604558 title "A Monocyte Chemoattractant Protein-1 (MCP-1) Polymorphism And Outcome After Renal Transplantation" @default.
• W2116604558 cites W1516434930 @default.
• W2116604558 cites W1965637646 @default.
• W2116604558 cites W1968415076 @default.
• W2116604558 cites W1979155203 @default.
• W2116604558 cites W1982915222 @default.
• W2116604558 cites W1986610158 @default.
• W2116604558 cites W1997038535 @default.
• W2116604558 cites W2010465633 @default.
• W2116604558 cites W2030065508 @default.
• W2116604558 cites W2037572297 @default.
• W2116604558 cites W2054612924 @default.
• W2116604558 cites W2056883845 @default.
• W2116604558 cites W2057785869 @default.
• W2116604558 cites W2058754454 @default.
• W2116604558 cites W2060741577 @default.
• W2116604558 cites W2070541838 @default.
• W2116604558 cites W2092186657 @default.
• W2116604558 cites W2094391172 @default.
• W2116604558 cites W2115163080 @default.
• W2116604558 cites W2128044195 @default.
• W2116604558 cites W2142777298 @default.
• W2116604558 cites W2145544856 @default.
• W2116604558 cites W2149730509 @default.
• W2116604558 cites W2150404158 @default.
• W2116604558 cites W2332741537 @default.
• W2116604558 cites W4238336108 @default.
• W2116604558 doi "https://doi.org/10.1097/01.asn.0000031701.53792.54" @default.
• W2116604558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12239249" @default.
• W2116604558 hasPublicationYear "2002" @default.
• W2116604558 type Work @default.
• W2116604558 sameAs 2116604558 @default.
• W2116604558 citedByCount "93" @default.
• W2116604558 countsByYear W21166045582012 @default.
• W2116604558 countsByYear W21166045582013 @default.
• W2116604558 countsByYear W21166045582014 @default.
• W2116604558 countsByYear W21166045582015 @default.
• W2116604558 countsByYear W21166045582016 @default.
• W2116604558 countsByYear W21166045582017 @default.
• W2116604558 countsByYear W21166045582018 @default.
• W2116604558 countsByYear W21166045582020 @default.
• W2116604558 countsByYear W21166045582021 @default.
• W2116604558 countsByYear W21166045582022 @default.
• W2116604558 countsByYear W21166045582023 @default.
• W2116604558 crossrefType "journal-article" @default.
• W2116604558 hasAuthorship W2116604558A5000738249 @default.
• W2116604558 hasAuthorship W2116604558A5006009691 @default.
• W2116604558 hasAuthorship W2116604558A5012021516 @default.
• W2116604558 hasAuthorship W2116604558A5014537121 @default.
• W2116604558 hasAuthorship W2116604558A5015465551 @default.
• W2116604558 hasAuthorship W2116604558A5027429186 @default.
• W2116604558 hasAuthorship W2116604558A5075653724 @default.
• W2116604558 hasAuthorship W2116604558A5079705894 @default.
• W2116604558 hasBestOaLocation W21166045581 @default.
• W2116604558 hasConcept C104317684 @default.
• W2116604558 hasConcept C126322002 @default.
• W2116604558 hasConcept C12823836 @default.
• W2116604558 hasConcept C13373296 @default.
• W2116604558 hasConcept C135763542 @default.
• W2116604558 hasConcept C170493617 @default.
• W2116604558 hasConcept C180754005 @default.
• W2116604558 hasConcept C203014093 @default.
• W2116604558 hasConcept C206615009 @default.
• W2116604558 hasConcept C2778653478 @default.
• W2116604558 hasConcept C2780091579 @default.
• W2116604558 hasConcept C2780303639 @default.
• W2116604558 hasConcept C2911091166 @default.
• W2116604558 hasConcept C54355233 @default.
• W2116604558 hasConcept C71924100 @default.
• W2116604558 hasConcept C86803240 @default.
• W2116604558 hasConcept C90924648 @default.
• W2116604558 hasConceptScore W2116604558C104317684 @default.
• W2116604558 hasConceptScore W2116604558C126322002 @default.
• W2116604558 hasConceptScore W2116604558C12823836 @default.
• W2116604558 hasConceptScore W2116604558C13373296 @default.
• W2116604558 hasConceptScore W2116604558C135763542 @default.
• W2116604558 hasConceptScore W2116604558C170493617 @default.
• W2116604558 hasConceptScore W2116604558C180754005 @default.
• W2116604558 hasConceptScore W2116604558C203014093 @default.
• W2116604558 hasConceptScore W2116604558C206615009 @default.
• W2116604558 hasConceptScore W2116604558C2778653478 @default.
• W2116604558 hasConceptScore W2116604558C2780091579 @default.
• W2116604558 hasConceptScore W2116604558C2780303639 @default.
• W2116604558 hasConceptScore W2116604558C2911091166 @default.
• W2116604558 hasConceptScore W2116604558C54355233 @default.
• W2116604558 hasConceptScore W2116604558C71924100 @default.

• next