FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116639780> ?p ?o ?g. }

• W2116639780 endingPage "77" @default.
• W2116639780 startingPage "71" @default.
• W2116639780 abstract "A natural brassinosteroid and a series of synthetic derivatives were found to be good inhibitors of herpes simplex virus type 1 (HSV-1) and arenavirus replication in cell culture. The synthetic compounds tested were analogues of the 24(S) ethylbrassinone. Compounds (22R,23R,24S)-2α, 3α,5α,22,23-pentahydroxy-stigmastan-6-one and (22R,23R,24S)-3β-bromo-5α,22,23-trihydroxy stigmastan-6-one were cytotoxic at concentrations of 20–40 µM. (22S,23S,24S)-2α,3α,22,23-tetrahydroxy-5α,stigmastan-6-one, (22R,23R,24S)-3β-acetoxy-22,23-dihydroxy-5α-cholestan-6-one, (22S,23S,24S)-3β-bromo-22,23-dihydroxy-5α-cholestan-6-one and (22S,23S,24S)-3β-bromo-5α,22,23-trihydroxy-stigmastan-6-one were the most active of the series against HSV-1, with selectivity index (SI) values (CC 50 /EC 50 ) ranging from 10.6 to 16.5. The majority of the compounds were potent inhibitors of arenaviruses, (22S,23S,24S)-3β-bromo-5α,22,23-trihydroxy-stigmastan-6-one being the most active, with SI values of 307.8 and 692.5 for Tacaribe and Junin viruses, respectively. The antiviral activity of brassinosteroid derivatives was not because of direct inactivation; time-of-addition experiments suggested that a late step in HSV-1 multiplication was affected, whereas arenaviruses remained susceptible to the compounds throughout the replicative cycle." @default.
• W2116639780 created "2016-06-24" @default.
• W2116639780 creator A5017554114 @default.
• W2116639780 creator A5029115389 @default.
• W2116639780 creator A5068420897 @default.
• W2116639780 creator A5070838852 @default.
• W2116639780 creator A5088288538 @default.
• W2116639780 date "2000-02-01" @default.
• W2116639780 modified "2023-10-04" @default.
• W2116639780 title "Antiviral Effect of Brassinosteroids against Herpes Virus and Arenaviruses" @default.
• W2116639780 cites W1629179716 @default.
• W2116639780 cites W167712461 @default.
• W2116639780 cites W1973497192 @default.
• W2116639780 cites W1974579934 @default.
• W2116639780 cites W1976791899 @default.
• W2116639780 cites W1978048628 @default.
• W2116639780 cites W1985270166 @default.
• W2116639780 cites W1991509224 @default.
• W2116639780 cites W1991882827 @default.
• W2116639780 cites W1996798433 @default.
• W2116639780 cites W2019455710 @default.
• W2116639780 cites W2034616315 @default.
• W2116639780 cites W2038413399 @default.
• W2116639780 cites W2058496943 @default.
• W2116639780 cites W2074941691 @default.
• W2116639780 cites W2083556261 @default.
• W2116639780 cites W2087610677 @default.
• W2116639780 cites W2090793408 @default.
• W2116639780 cites W314773953 @default.
• W2116639780 cites W4240799279 @default.
• W2116639780 doi "https://doi.org/10.1177/095632020001100107" @default.
• W2116639780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10693656" @default.
• W2116639780 hasPublicationYear "2000" @default.
• W2116639780 type Work @default.
• W2116639780 sameAs 2116639780 @default.
• W2116639780 citedByCount "82" @default.
• W2116639780 countsByYear W21166397802012 @default.
• W2116639780 countsByYear W21166397802013 @default.
• W2116639780 countsByYear W21166397802014 @default.
• W2116639780 countsByYear W21166397802015 @default.
• W2116639780 countsByYear W21166397802016 @default.
• W2116639780 countsByYear W21166397802017 @default.
• W2116639780 countsByYear W21166397802018 @default.
• W2116639780 countsByYear W21166397802019 @default.
• W2116639780 countsByYear W21166397802020 @default.
• W2116639780 countsByYear W21166397802021 @default.
• W2116639780 countsByYear W21166397802022 @default.
• W2116639780 countsByYear W21166397802023 @default.
• W2116639780 crossrefType "journal-article" @default.
• W2116639780 hasAuthorship W2116639780A5017554114 @default.
• W2116639780 hasAuthorship W2116639780A5029115389 @default.
• W2116639780 hasAuthorship W2116639780A5068420897 @default.
• W2116639780 hasAuthorship W2116639780A5070838852 @default.
• W2116639780 hasAuthorship W2116639780A5088288538 @default.
• W2116639780 hasConcept C104317684 @default.
• W2116639780 hasConcept C140704245 @default.
• W2116639780 hasConcept C143065580 @default.
• W2116639780 hasConcept C154317977 @default.
• W2116639780 hasConcept C159047783 @default.
• W2116639780 hasConcept C185592680 @default.
• W2116639780 hasConcept C202751555 @default.
• W2116639780 hasConcept C2522874641 @default.
• W2116639780 hasConcept C2775955205 @default.
• W2116639780 hasConcept C2778778573 @default.
• W2116639780 hasConcept C2779491563 @default.
• W2116639780 hasConcept C2779574689 @default.
• W2116639780 hasConcept C2780190958 @default.
• W2116639780 hasConcept C2781196997 @default.
• W2116639780 hasConcept C55493867 @default.
• W2116639780 hasConcept C71240020 @default.
• W2116639780 hasConcept C86803240 @default.
• W2116639780 hasConceptScore W2116639780C104317684 @default.
• W2116639780 hasConceptScore W2116639780C140704245 @default.
• W2116639780 hasConceptScore W2116639780C143065580 @default.
• W2116639780 hasConceptScore W2116639780C154317977 @default.
• W2116639780 hasConceptScore W2116639780C159047783 @default.
• W2116639780 hasConceptScore W2116639780C185592680 @default.
• W2116639780 hasConceptScore W2116639780C202751555 @default.
• W2116639780 hasConceptScore W2116639780C2522874641 @default.
• W2116639780 hasConceptScore W2116639780C2775955205 @default.
• W2116639780 hasConceptScore W2116639780C2778778573 @default.
• W2116639780 hasConceptScore W2116639780C2779491563 @default.
• W2116639780 hasConceptScore W2116639780C2779574689 @default.
• W2116639780 hasConceptScore W2116639780C2780190958 @default.
• W2116639780 hasConceptScore W2116639780C2781196997 @default.
• W2116639780 hasConceptScore W2116639780C55493867 @default.
• W2116639780 hasConceptScore W2116639780C71240020 @default.
• W2116639780 hasConceptScore W2116639780C86803240 @default.
• W2116639780 hasIssue "1" @default.
• W2116639780 hasLocation W21166397801 @default.
• W2116639780 hasLocation W21166397802 @default.
• W2116639780 hasOpenAccess W2116639780 @default.
• W2116639780 hasPrimaryLocation W21166397801 @default.
• W2116639780 hasRelatedWork W1645018133 @default.
• W2116639780 hasRelatedWork W1910606105 @default.
• W2116639780 hasRelatedWork W1964765195 @default.
• W2116639780 hasRelatedWork W2022412258 @default.
• W2116639780 hasRelatedWork W2040369045 @default.

• next