Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116643715> ?p ?o ?g. }
- W2116643715 endingPage "434" @default.
- W2116643715 startingPage "424" @default.
- W2116643715 abstract "The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health crisis worldwide. In particular, meticillin-resistant Staphylococcus aureus (MRSA), a pathogen responsible for numerous human infections, has become endemic in hospitals worldwide. Drug repurposing, the finding of new therapeutic indications for approved drugs, is deemed a plausible solution to accelerate drug discovery and development in this area. Towards this end, we screened 1163 drugs approved by the Food and Drug Administration (FDA) for bioactivities against MRSA in a 10 μM single-point assay. After excluding known antibiotics and antiseptics, six compounds were identified and their MICs were determined against a panel of clinical MRSA strains. A toxicity assay using human keratinocytes was also conducted to gauge their potential for repurposing as topical agents for treating MRSA skin infections." @default.
- W2116643715 created "2016-06-24" @default.
- W2116643715 creator A5002384844 @default.
- W2116643715 creator A5002673952 @default.
- W2116643715 creator A5029426071 @default.
- W2116643715 creator A5051284876 @default.
- W2116643715 creator A5060863574 @default.
- W2116643715 creator A5071922835 @default.
- W2116643715 creator A5078895790 @default.
- W2116643715 creator A5084022032 @default.
- W2116643715 date "2015-10-09" @default.
- W2116643715 modified "2023-09-23" @default.
- W2116643715 title "An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA)" @default.
- W2116643715 cites W102725257 @default.
- W2116643715 cites W1758254255 @default.
- W2116643715 cites W1975987237 @default.
- W2116643715 cites W1980253503 @default.
- W2116643715 cites W1984328540 @default.
- W2116643715 cites W1987730034 @default.
- W2116643715 cites W1991471402 @default.
- W2116643715 cites W1997106161 @default.
- W2116643715 cites W2000087732 @default.
- W2116643715 cites W2002527761 @default.
- W2116643715 cites W2041856923 @default.
- W2116643715 cites W2050211725 @default.
- W2116643715 cites W2059494851 @default.
- W2116643715 cites W2061708150 @default.
- W2116643715 cites W2062605727 @default.
- W2116643715 cites W2062941476 @default.
- W2116643715 cites W2068017239 @default.
- W2116643715 cites W2078078890 @default.
- W2116643715 cites W2081747790 @default.
- W2116643715 cites W2098533519 @default.
- W2116643715 cites W2108433768 @default.
- W2116643715 cites W2108919162 @default.
- W2116643715 cites W2111188921 @default.
- W2116643715 cites W2115486016 @default.
- W2116643715 cites W2116607488 @default.
- W2116643715 cites W2121973786 @default.
- W2116643715 cites W2121978874 @default.
- W2116643715 cites W2125066910 @default.
- W2116643715 cites W2131316809 @default.
- W2116643715 cites W2133569576 @default.
- W2116643715 cites W2134773678 @default.
- W2116643715 cites W2139516496 @default.
- W2116643715 cites W2140868856 @default.
- W2116643715 cites W2147652807 @default.
- W2116643715 cites W2148792925 @default.
- W2116643715 cites W2150598343 @default.
- W2116643715 cites W2154400082 @default.
- W2116643715 cites W2156825730 @default.
- W2116643715 cites W2165496299 @default.
- W2116643715 cites W2169172209 @default.
- W2116643715 cites W4232866872 @default.
- W2116643715 cites W4239007995 @default.
- W2116643715 doi "https://doi.org/10.3390/antibiotics4040424" @default.
- W2116643715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4790305" @default.
- W2116643715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27025633" @default.
- W2116643715 hasPublicationYear "2015" @default.
- W2116643715 type Work @default.
- W2116643715 sameAs 2116643715 @default.
- W2116643715 citedByCount "15" @default.
- W2116643715 countsByYear W21166437152016 @default.
- W2116643715 countsByYear W21166437152017 @default.
- W2116643715 countsByYear W21166437152018 @default.
- W2116643715 countsByYear W21166437152019 @default.
- W2116643715 countsByYear W21166437152020 @default.
- W2116643715 countsByYear W21166437152021 @default.
- W2116643715 countsByYear W21166437152022 @default.
- W2116643715 countsByYear W21166437152023 @default.
- W2116643715 crossrefType "journal-article" @default.
- W2116643715 hasAuthorship W2116643715A5002384844 @default.
- W2116643715 hasAuthorship W2116643715A5002673952 @default.
- W2116643715 hasAuthorship W2116643715A5029426071 @default.
- W2116643715 hasAuthorship W2116643715A5051284876 @default.
- W2116643715 hasAuthorship W2116643715A5060863574 @default.
- W2116643715 hasAuthorship W2116643715A5071922835 @default.
- W2116643715 hasAuthorship W2116643715A5078895790 @default.
- W2116643715 hasAuthorship W2116643715A5084022032 @default.
- W2116643715 hasBestOaLocation W21166437151 @default.
- W2116643715 hasConcept C103637391 @default.
- W2116643715 hasConcept C18903297 @default.
- W2116643715 hasConcept C2777052132 @default.
- W2116643715 hasConcept C2779489039 @default.
- W2116643715 hasConcept C2780035454 @default.
- W2116643715 hasConcept C501593827 @default.
- W2116643715 hasConcept C519536355 @default.
- W2116643715 hasConcept C523546767 @default.
- W2116643715 hasConcept C54355233 @default.
- W2116643715 hasConcept C71924100 @default.
- W2116643715 hasConcept C86803240 @default.
- W2116643715 hasConcept C89423630 @default.
- W2116643715 hasConcept C98274493 @default.
- W2116643715 hasConceptScore W2116643715C103637391 @default.
- W2116643715 hasConceptScore W2116643715C18903297 @default.
- W2116643715 hasConceptScore W2116643715C2777052132 @default.
- W2116643715 hasConceptScore W2116643715C2779489039 @default.
- W2116643715 hasConceptScore W2116643715C2780035454 @default.