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- W2116669977 abstract "ABSTRACT While scaffold proteins are thought to be key components of signaling pathways, their exact function is unknown. By preassembling multiple components of signaling cascades, scaffolds are predicted to influence the efficiency and/or specificity of signaling events. Here we analyze a potential scaffold of the Ras/mitogen-activated protein kinase (MAPK) pathway, kinase suppressor of Ras (KSR), by generating KSR-deficient mice. KSR-deficient mice were grossly normal even though ERK kinase activation was attenuated to a degree sufficient to block T-cell activation and inhibit tumor development. Consistent with its role as a scaffold, high-molecular-weight complexes containing KSR, MEK, and ERK were lost in the absence of KSR. This demonstrates that KSR is a bona fide scaffold that is not required for but enhances signaling via the Ras/MAPK signaling pathway." @default.
- W2116669977 created "2016-06-24" @default.
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- W2116669977 date "2002-05-01" @default.
- W2116669977 modified "2023-10-16" @default.
- W2116669977 title "Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo" @default.
- W2116669977 cites W1486631729 @default.
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- W2116669977 cites W1544291870 @default.
- W2116669977 cites W1597170724 @default.
- W2116669977 cites W18630108 @default.
- W2116669977 cites W1899552864 @default.
- W2116669977 cites W1921076722 @default.
- W2116669977 cites W1928407971 @default.
- W2116669977 cites W1967400782 @default.
- W2116669977 cites W1972187212 @default.
- W2116669977 cites W1972812612 @default.
- W2116669977 cites W1973607853 @default.
- W2116669977 cites W1975566386 @default.
- W2116669977 cites W1985766276 @default.
- W2116669977 cites W1990205029 @default.
- W2116669977 cites W1991062831 @default.
- W2116669977 cites W1995205975 @default.
- W2116669977 cites W1997656209 @default.
- W2116669977 cites W2007665864 @default.
- W2116669977 cites W2011184275 @default.
- W2116669977 cites W2013436886 @default.
- W2116669977 cites W2017194364 @default.
- W2116669977 cites W2020257412 @default.
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- W2116669977 cites W2045500858 @default.
- W2116669977 cites W2047604959 @default.
- W2116669977 cites W2049573270 @default.
- W2116669977 cites W2052122921 @default.
- W2116669977 cites W2057392977 @default.
- W2116669977 cites W2060840912 @default.
- W2116669977 cites W2061241669 @default.
- W2116669977 cites W2069431286 @default.
- W2116669977 cites W2069501059 @default.
- W2116669977 cites W2070330987 @default.
- W2116669977 cites W2072243374 @default.
- W2116669977 cites W2074303585 @default.
- W2116669977 cites W2074951828 @default.
- W2116669977 cites W2076485183 @default.
- W2116669977 cites W2077086907 @default.
- W2116669977 cites W2078065785 @default.
- W2116669977 cites W2079618910 @default.
- W2116669977 cites W2082542299 @default.
- W2116669977 cites W2085931606 @default.
- W2116669977 cites W2086419819 @default.
- W2116669977 cites W2086940038 @default.
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- W2116669977 cites W2128321311 @default.
- W2116669977 cites W2140851951 @default.
- W2116669977 cites W2142242441 @default.
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- W2116669977 cites W2149242879 @default.
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- W2116669977 doi "https://doi.org/10.1128/mcb.22.9.3035-3045.2002" @default.
- W2116669977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133772" @default.
- W2116669977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11940661" @default.
- W2116669977 hasPublicationYear "2002" @default.
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