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- W2116670265 abstract "Clathrin-mediated endocytosis (CME) is a fundamental property of eukaryotic cells. Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma membrane, which invaginate to form clathrin-coated vesicles, a process that is well understood. However, clathrin also assembles into flat clathrin lattices (FCLs); these structures remain poorly described, and their contribution to cell biology is unclear. We used quantitative imaging to provide the first comprehensive description of FCLs and explore their influence on plasma membrane organization. Ultrastructural analysis by electron and superresolution microscopy revealed two discrete populations of clathrin structures. CCPs were typified by their sphericity, small size, and homogeneity. FCLs were planar, large, and heterogeneous and present on both the dorsal and ventral surfaces of cells. Live microscopy demonstrated that CCPs are short lived and culminate in a peak of dynamin recruitment, consistent with classical CME. In contrast, FCLs were long lived, with sustained association with dynamin. We investigated the biological relevance of FCLs using the chemokine receptor CCR5 as a model system. Agonist activation leads to sustained recruitment of CCR5 to FCLs. Quantitative molecular imaging indicated that FCLs partitioned receptors at the cell surface. Our observations suggest that FCLs provide stable platforms for the recruitment of endocytic cargo." @default.
- W2116670265 created "2016-06-24" @default.
- W2116670265 creator A5000014285 @default.
- W2116670265 creator A5000877747 @default.
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- W2116670265 creator A5074583242 @default.
- W2116670265 creator A5079491369 @default.
- W2116670265 creator A5082205771 @default.
- W2116670265 date "2014-11-05" @default.
- W2116670265 modified "2023-09-27" @default.
- W2116670265 title "Flat clathrin lattices: stable features of the plasma membrane" @default.
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