FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116673057> ?p ?o ?g. }

• W2116673057 endingPage "181" @default.
• W2116673057 startingPage "167" @default.
• W2116673057 abstract "BAP and PBAP constitute the two different forms of the Drosophila melanogaster Brahma chromatin remodelers. A common multisubunit core, containing the Brahma ATPase, can associate either with Osa to form the BAP complex or with Bap170, Bap180, and Sayp to constitute the PBAP complex. Although required for many biological processes, recent genetic analyses revealed that one role of the BAP complex during Drosophila wing development is the proper regulation of EGFR target genes. Here, we show that Bap170, a distinctive subunit of the PBAP complex, participates instead in the negative regulation of EGFR signaling. In adults, loss of Bap170 generates phenotypes similar to the defects induced by hyperactivation of the EGFR pathway, such as overrecruitment of cone and photoreceptor cells and formation extra veins. In genetic interactions, bap170 mutations suppress the loss of veins and photoreceptors caused by mutations affecting the activity of the EGFR pathway. Our results suggest a dual requirement of the PBAP complex: for transcriptional repression of rhomboid and for efficient expression of argos. Interestingly, genetic evidence also indicates that Bap170-mediated repression of rho is inhibited by EGFR signaling, suggesting a scenario of mutual antagonism between EGFR signaling and PBAP function." @default.
• W2116673057 created "2016-06-24" @default.
• W2116673057 creator A5003811100 @default.
• W2116673057 creator A5009569249 @default.
• W2116673057 creator A5011314524 @default.
• W2116673057 creator A5068957747 @default.
• W2116673057 date "2010-09-01" @default.
• W2116673057 modified "2023-10-03" @default.
• W2116673057 title "Bap170, a Subunit of the Drosophila PBAP Chromatin Remodeling Complex, Negatively Regulates the EGFR Signaling" @default.
• W2116673057 cites W1571942943 @default.
• W2116673057 cites W171537913 @default.
• W2116673057 cites W1792088282 @default.
• W2116673057 cites W1803466717 @default.
• W2116673057 cites W1885511547 @default.
• W2116673057 cites W1895529587 @default.
• W2116673057 cites W1900883967 @default.
• W2116673057 cites W1954101688 @default.
• W2116673057 cites W1970180329 @default.
• W2116673057 cites W1981322792 @default.
• W2116673057 cites W1981360723 @default.
• W2116673057 cites W1984437428 @default.
• W2116673057 cites W1990527048 @default.
• W2116673057 cites W1997694660 @default.
• W2116673057 cites W2004553881 @default.
• W2116673057 cites W2006229889 @default.
• W2116673057 cites W2011868306 @default.
• W2116673057 cites W2012179207 @default.
• W2116673057 cites W2013618640 @default.
• W2116673057 cites W2018753674 @default.
• W2116673057 cites W2023417672 @default.
• W2116673057 cites W2032157793 @default.
• W2116673057 cites W2036207377 @default.
• W2116673057 cites W2038560503 @default.
• W2116673057 cites W2038614254 @default.
• W2116673057 cites W2039110985 @default.
• W2116673057 cites W2039252526 @default.
• W2116673057 cites W2040107912 @default.
• W2116673057 cites W2042442387 @default.
• W2116673057 cites W2047958428 @default.
• W2116673057 cites W2050020992 @default.
• W2116673057 cites W2052646018 @default.
• W2116673057 cites W2053108921 @default.
• W2116673057 cites W2053933022 @default.
• W2116673057 cites W2058199749 @default.
• W2116673057 cites W2060047438 @default.
• W2116673057 cites W2063206483 @default.
• W2116673057 cites W2064411567 @default.
• W2116673057 cites W2081182483 @default.
• W2116673057 cites W2088541123 @default.
• W2116673057 cites W2097848338 @default.
• W2116673057 cites W2109638112 @default.
• W2116673057 cites W2109851339 @default.
• W2116673057 cites W2110643873 @default.
• W2116673057 cites W2119937553 @default.
• W2116673057 cites W2128920793 @default.
• W2116673057 cites W2132062633 @default.
• W2116673057 cites W2135306983 @default.
• W2116673057 cites W2140786734 @default.
• W2116673057 cites W2144217917 @default.
• W2116673057 cites W2146150648 @default.
• W2116673057 cites W2147655622 @default.
• W2116673057 cites W2158285204 @default.
• W2116673057 cites W2158825995 @default.
• W2116673057 cites W2162409772 @default.
• W2116673057 cites W2164403405 @default.
• W2116673057 cites W2164655389 @default.
• W2116673057 cites W2165054897 @default.
• W2116673057 cites W2170231361 @default.
• W2116673057 cites W2171835957 @default.
• W2116673057 cites W2184390227 @default.
• W2116673057 cites W2184956494 @default.
• W2116673057 cites W2440896660 @default.
• W2116673057 cites W4232042630 @default.
• W2116673057 cites W4376848581 @default.
• W2116673057 doi "https://doi.org/10.1534/genetics.110.118695" @default.
• W2116673057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2940285" @default.
• W2116673057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20551433" @default.
• W2116673057 hasPublicationYear "2010" @default.
• W2116673057 type Work @default.
• W2116673057 sameAs 2116673057 @default.
• W2116673057 citedByCount "11" @default.
• W2116673057 countsByYear W21166730572013 @default.
• W2116673057 countsByYear W21166730572015 @default.
• W2116673057 countsByYear W21166730572016 @default.
• W2116673057 countsByYear W21166730572020 @default.
• W2116673057 countsByYear W21166730572021 @default.
• W2116673057 countsByYear W21166730572022 @default.
• W2116673057 countsByYear W21166730572023 @default.
• W2116673057 crossrefType "journal-article" @default.
• W2116673057 hasAuthorship W2116673057A5003811100 @default.
• W2116673057 hasAuthorship W2116673057A5009569249 @default.
• W2116673057 hasAuthorship W2116673057A5011314524 @default.
• W2116673057 hasAuthorship W2116673057A5068957747 @default.
• W2116673057 hasBestOaLocation W21166730571 @default.
• W2116673057 hasConcept C104317684 @default.
• W2116673057 hasConcept C127716648 @default.
• W2116673057 hasConcept C14036430 @default.
• W2116673057 hasConcept C150194340 @default.

• next