Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116679423> ?p ?o ?g. }
- W2116679423 endingPage "648" @default.
- W2116679423 startingPage "637" @default.
- W2116679423 abstract "Recent postmortem and neuroimaging studies of schizophrenia delineate changes in brain structure and volume that appear to arise from a reduction of neuritic processes (such as dendrites and synapses) rather than loss of neuronal or glial cell bodies. To account for these findings, we propose a pathophysiological model of reduced synaptic connectivity arising from disturbances of brain development active during perinatal and adolescent periods. We review a computer simulation of the elimination of the synaptic connections that models normal cognitive development and psychotic symptom formation. We describe the model's key parameters and discuss how they can account for important aspects of schizophrenia, including its unique symptoms, short- and long-term course, typical age of onset, neurodevelopmental deficits, limited neurodegenerative progression, sex differences, and more. We discuss some of the model's predictions and questions raised for basic research, early detection, and preventive intervention." @default.
- W2116679423 created "2016-06-24" @default.
- W2116679423 creator A5047022638 @default.
- W2116679423 creator A5077549290 @default.
- W2116679423 date "2000-07-01" @default.
- W2116679423 modified "2023-09-30" @default.
- W2116679423 title "Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity" @default.
- W2116679423 cites W118865482 @default.
- W2116679423 cites W12580265 @default.
- W2116679423 cites W1509285273 @default.
- W2116679423 cites W1568392634 @default.
- W2116679423 cites W16142484 @default.
- W2116679423 cites W1704420030 @default.
- W2116679423 cites W172852266 @default.
- W2116679423 cites W1752801699 @default.
- W2116679423 cites W1852307392 @default.
- W2116679423 cites W185250620 @default.
- W2116679423 cites W1945334204 @default.
- W2116679423 cites W1957898531 @default.
- W2116679423 cites W1964007647 @default.
- W2116679423 cites W1964388608 @default.
- W2116679423 cites W1965502156 @default.
- W2116679423 cites W1967605871 @default.
- W2116679423 cites W1969061733 @default.
- W2116679423 cites W1969273085 @default.
- W2116679423 cites W1969729492 @default.
- W2116679423 cites W1970311420 @default.
- W2116679423 cites W1971251178 @default.
- W2116679423 cites W1972028705 @default.
- W2116679423 cites W1973396046 @default.
- W2116679423 cites W1974535416 @default.
- W2116679423 cites W1976376002 @default.
- W2116679423 cites W1976655188 @default.
- W2116679423 cites W1976775610 @default.
- W2116679423 cites W1976902101 @default.
- W2116679423 cites W1977410909 @default.
- W2116679423 cites W1978761618 @default.
- W2116679423 cites W1979215369 @default.
- W2116679423 cites W1979738236 @default.
- W2116679423 cites W1980390198 @default.
- W2116679423 cites W1981424200 @default.
- W2116679423 cites W1983488247 @default.
- W2116679423 cites W1983766539 @default.
- W2116679423 cites W1983955994 @default.
- W2116679423 cites W1984059331 @default.
- W2116679423 cites W1984111997 @default.
- W2116679423 cites W1984118513 @default.
- W2116679423 cites W1985853034 @default.
- W2116679423 cites W1986863179 @default.
- W2116679423 cites W1987149240 @default.
- W2116679423 cites W1987498894 @default.
- W2116679423 cites W1989238993 @default.
- W2116679423 cites W1990060408 @default.
- W2116679423 cites W1990749425 @default.
- W2116679423 cites W1991891815 @default.
- W2116679423 cites W1992790571 @default.
- W2116679423 cites W1993201831 @default.
- W2116679423 cites W1993206740 @default.
- W2116679423 cites W1993986427 @default.
- W2116679423 cites W1994517931 @default.
- W2116679423 cites W1995362640 @default.
- W2116679423 cites W1995858644 @default.
- W2116679423 cites W1997413910 @default.
- W2116679423 cites W1998328043 @default.
- W2116679423 cites W1999456758 @default.
- W2116679423 cites W2001659218 @default.
- W2116679423 cites W2003288100 @default.
- W2116679423 cites W2004535146 @default.
- W2116679423 cites W2005137243 @default.
- W2116679423 cites W2006734443 @default.
- W2116679423 cites W2007040931 @default.
- W2116679423 cites W2007550342 @default.
- W2116679423 cites W2009920684 @default.
- W2116679423 cites W2010230693 @default.
- W2116679423 cites W2016008469 @default.
- W2116679423 cites W2016264497 @default.
- W2116679423 cites W2016312600 @default.
- W2116679423 cites W2017450369 @default.
- W2116679423 cites W2020979712 @default.
- W2116679423 cites W2021216098 @default.
- W2116679423 cites W2021712024 @default.
- W2116679423 cites W2022113071 @default.
- W2116679423 cites W2022407796 @default.
- W2116679423 cites W2022473661 @default.
- W2116679423 cites W2024913433 @default.
- W2116679423 cites W2025011978 @default.
- W2116679423 cites W2025606283 @default.
- W2116679423 cites W2026965872 @default.
- W2116679423 cites W2027077457 @default.
- W2116679423 cites W2027517286 @default.
- W2116679423 cites W2027973539 @default.
- W2116679423 cites W2028693746 @default.
- W2116679423 cites W2029303977 @default.
- W2116679423 cites W2030913443 @default.
- W2116679423 cites W2032549692 @default.
- W2116679423 cites W2033413590 @default.
- W2116679423 cites W2033897755 @default.
- W2116679423 cites W2034008819 @default.