FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116683918> ?p ?o ?g. }

• W2116683918 endingPage "185" @default.
• W2116683918 startingPage "178" @default.
• W2116683918 abstract "Four putative single nucleotide polymorphism (SNP) risk variants at the preeclampsia susceptibility locus on chromosome 2q22; rs2322659 (LCT), rs35821928 (LRP1B), rs115015150 (RND3) and rs17783344 (GCA), were recently shown to associate with known cardiovascular risk factors in a Mexican American cohort. This study aimed to further evaluate the pleiotropic effects of these preeclampsia risk variants in an independent Australian population-based cohort.The four SNPs were genotyped in the Western Australian Pregnancy Cohort (Raine) Study that included DNA, clinical and biochemical data from 1246 mothers and 1404 of their now adolescent offspring. Genotype association analyses were undertaken using the SOLAR software.Nominal associations (P<0.05) with cardiovascular risk factors were detected for all four SNPs. The LCT SNP was associated with decreased maternal height (P=0.005) and decreased blood glucose levels in adolescents (P=0.022). The LRP1B SNP was associated with increased maternal height (P=0.026) and decreased maternal weight (P=0.044). The RND3 SNP was associated with decreased triglycerides in adolescents (P=0.001). The GCA SNP was associated with lower risk in adolescents to be born of a preeclamptic pregnancy (P=0.003) and having a mother with prior preeclamptic pregnancy (P=0.033).Our collective findings support the hypothesis that genetic mechanisms for preeclampsia and CVD are, at least in part, shared, but need to be interpreted with some caution as a Bonferroni correction for multiple testing adjusted the statistical significance threshold (adjusted P<0.001)." @default.
• W2116683918 created "2016-06-24" @default.
• W2116683918 creator A5004538115 @default.
• W2116683918 creator A5024230104 @default.
• W2116683918 creator A5027048775 @default.
• W2116683918 creator A5045012584 @default.
• W2116683918 creator A5047311877 @default.
• W2116683918 creator A5065841046 @default.
• W2116683918 creator A5069006550 @default.
• W2116683918 creator A5073224358 @default.
• W2116683918 creator A5076433645 @default.
• W2116683918 creator A5077342690 @default.
• W2116683918 creator A5083624454 @default.
• W2116683918 creator A5084039553 @default.
• W2116683918 creator A5086503058 @default.
• W2116683918 creator A5087599552 @default.
• W2116683918 creator A5087859639 @default.
• W2116683918 date "2014-04-01" @default.
• W2116683918 modified "2023-09-26" @default.
• W2116683918 title "Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22" @default.
• W2116683918 cites W1557482814 @default.
• W2116683918 cites W1964044639 @default.
• W2116683918 cites W1966324370 @default.
• W2116683918 cites W1967186095 @default.
• W2116683918 cites W1974664167 @default.
• W2116683918 cites W1974801923 @default.
• W2116683918 cites W1986428805 @default.
• W2116683918 cites W1986841378 @default.
• W2116683918 cites W1993286003 @default.
• W2116683918 cites W2000035786 @default.
• W2116683918 cites W2000911886 @default.
• W2116683918 cites W2003774981 @default.
• W2116683918 cites W2005848269 @default.
• W2116683918 cites W2009542299 @default.
• W2116683918 cites W2018682790 @default.
• W2116683918 cites W2020823922 @default.
• W2116683918 cites W2035307313 @default.
• W2116683918 cites W2036677302 @default.
• W2116683918 cites W2049887195 @default.
• W2116683918 cites W2051213492 @default.
• W2116683918 cites W2057873969 @default.
• W2116683918 cites W2066241675 @default.
• W2116683918 cites W2073734569 @default.
• W2116683918 cites W2075827989 @default.
• W2116683918 cites W2076183375 @default.
• W2116683918 cites W2090196360 @default.
• W2116683918 cites W2100011676 @default.
• W2116683918 cites W2110243778 @default.
• W2116683918 cites W2115335486 @default.
• W2116683918 cites W2116578245 @default.
• W2116683918 cites W2117697673 @default.
• W2116683918 cites W2122423878 @default.
• W2116683918 cites W2123949130 @default.
• W2116683918 cites W2132643733 @default.
• W2116683918 cites W2133644204 @default.
• W2116683918 cites W2136558851 @default.
• W2116683918 cites W2141164566 @default.
• W2116683918 cites W2147311167 @default.
• W2116683918 cites W2147829211 @default.
• W2116683918 cites W2148779788 @default.
• W2116683918 cites W2149194464 @default.
• W2116683918 cites W2169421412 @default.
• W2116683918 cites W2171125437 @default.
• W2116683918 cites W2171277873 @default.
• W2116683918 doi "https://doi.org/10.1016/j.preghy.2014.03.005" @default.
• W2116683918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26104425" @default.
• W2116683918 hasPublicationYear "2014" @default.
• W2116683918 type Work @default.
• W2116683918 sameAs 2116683918 @default.
• W2116683918 citedByCount "13" @default.
• W2116683918 countsByYear W21166839182014 @default.
• W2116683918 countsByYear W21166839182016 @default.
• W2116683918 countsByYear W21166839182017 @default.
• W2116683918 countsByYear W21166839182018 @default.
• W2116683918 countsByYear W21166839182019 @default.
• W2116683918 countsByYear W21166839182020 @default.
• W2116683918 countsByYear W21166839182021 @default.
• W2116683918 countsByYear W21166839182022 @default.
• W2116683918 countsByYear W21166839182023 @default.
• W2116683918 crossrefType "journal-article" @default.
• W2116683918 hasAuthorship W2116683918A5004538115 @default.
• W2116683918 hasAuthorship W2116683918A5024230104 @default.
• W2116683918 hasAuthorship W2116683918A5027048775 @default.
• W2116683918 hasAuthorship W2116683918A5045012584 @default.
• W2116683918 hasAuthorship W2116683918A5047311877 @default.
• W2116683918 hasAuthorship W2116683918A5065841046 @default.
• W2116683918 hasAuthorship W2116683918A5069006550 @default.
• W2116683918 hasAuthorship W2116683918A5073224358 @default.
• W2116683918 hasAuthorship W2116683918A5076433645 @default.
• W2116683918 hasAuthorship W2116683918A5077342690 @default.
• W2116683918 hasAuthorship W2116683918A5083624454 @default.
• W2116683918 hasAuthorship W2116683918A5084039553 @default.
• W2116683918 hasAuthorship W2116683918A5086503058 @default.
• W2116683918 hasAuthorship W2116683918A5087599552 @default.
• W2116683918 hasAuthorship W2116683918A5087859639 @default.
• W2116683918 hasConcept C104317684 @default.
• W2116683918 hasConcept C106208931 @default.
• W2116683918 hasConcept C112672928 @default.

• next