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- W2116692034 abstract "Few recent scientific advances have captured the imagination of biologists and the general public like the prospect of animal cloning (1, 2). The procedure is elegantly simple. A nucleus from a mature cell is transferred into the cytoplasm of an enucleated egg and becomes “reprogrammed” to re-execute embryogenesis. That cloning has been successful at all seems biologically remarkable and has forced biologists to assess what cell differentiation is all about. However, although possible, the process has many complications (3–5). Fetal and placental weight are often dramatically increased. Animals also frequently suffer from congenital anomalies and die within hours of birth. Embryonic and fetal losses are also extremely high, such that far less than 1% of manipulated embryos give rise to live-born animals. These grim facts, collectively termed here cloned offspring syndrome, have raised considerable concern about the cloning process. The reasons for these complications have remained a mystery. However, work from the Jaenisch lab, culminating in a paper by Eggan et al. in this issue (6), has systematically addressed the problem and revealed surprising conclusions. Mechanisms related to fetoplacental growth should be the focus of research aimed at understanding nuclear reprogramming." @default.
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- W2116692034 date "2001-05-22" @default.
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- W2116692034 title "Factors affecting the developmental potential of cloned mammalian embryos" @default.
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- W2116692034 doi "https://doi.org/10.1073/pnas.111182398" @default.
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