FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116697914> ?p ?o ?g. }

• W2116697914 endingPage "656" @default.
• W2116697914 startingPage "643" @default.
• W2116697914 abstract "Somatostatin and its long-acting analogues have been introduced for the treatment of endocrine tumours of the gastrointestinal tract as they have been shown to effectively control symptoms resulting from excessive hormone release in patients with carcinoid, Verner-Morrison and glucagonoma syndromes. This beneficial effect is due to the presence of somatostatin receptors in high densities on the majority of endocrine tumours. The symptomatic effect is less pronounced in insulinomas, since 30 - 50% of these tumours lack or express only a few somatostatin receptors. With respect to symptomatic control, somatostatin receptor subtypes 2 and 5 are the most important and the currently available long-acting analogues octreotide and lanreotide bind preferentially to these receptor subtypes. Long-term studies have shown that somatostatin analogues are safe and that the most important adverse advent is the development of gallstones. The antiproliferative potency of somatostatin and its analogues in vitro and in experimental tumour models prompted a number of studies in patients with metastatic endocrine tumours that are generally unresponsive to conventional chemotherapeutic protocols. Stabilisation of tumour growth lasting for months to a few years was the most favourable result, occurring in 30 - 70% of patients. However, definite proof of antiproliferative potency in man is still pending since placebo-controlled studies are not available. Radioligand therapy based on 111Indium, 90Yttrium and 177Lutetium coupled to somatostatin analogues via bifunctional chelators is currently under investigation with promising data concerning long-lasting control of symptoms and tumour growth from Phase I trials." @default.
• W2116697914 created "2016-06-24" @default.
• W2116697914 creator A5018028476 @default.
• W2116697914 creator A5058035530 @default.
• W2116697914 creator A5013799194 @default.
• W2116697914 date "2002-06-01" @default.
• W2116697914 modified "2023-09-30" @default.
• W2116697914 title "Somatostatin analogues in the treatment of endocrine tumours of the gastrointestinal tract" @default.
• W2116697914 cites W1480909434 @default.
• W2116697914 cites W1583543360 @default.
• W2116697914 cites W1898402948 @default.
• W2116697914 cites W1935825021 @default.
• W2116697914 cites W1964862746 @default.
• W2116697914 cites W1966592733 @default.
• W2116697914 cites W1968667610 @default.
• W2116697914 cites W1970088269 @default.
• W2116697914 cites W1970185366 @default.
• W2116697914 cites W1975874471 @default.
• W2116697914 cites W1976198807 @default.
• W2116697914 cites W1977187256 @default.
• W2116697914 cites W1977347411 @default.
• W2116697914 cites W1986972777 @default.
• W2116697914 cites W1989552774 @default.
• W2116697914 cites W1991235684 @default.
• W2116697914 cites W1993265265 @default.
• W2116697914 cites W1993421446 @default.
• W2116697914 cites W1998933514 @default.
• W2116697914 cites W2004099663 @default.
• W2116697914 cites W2006962214 @default.
• W2116697914 cites W2011187030 @default.
• W2116697914 cites W2012600554 @default.
• W2116697914 cites W2013990610 @default.
• W2116697914 cites W2014458083 @default.
• W2116697914 cites W2016416363 @default.
• W2116697914 cites W2020146565 @default.
• W2116697914 cites W2022203930 @default.
• W2116697914 cites W2022563719 @default.
• W2116697914 cites W2023848705 @default.
• W2116697914 cites W2027867142 @default.
• W2116697914 cites W2030553092 @default.
• W2116697914 cites W2031463546 @default.
• W2116697914 cites W2032952937 @default.
• W2116697914 cites W2033922818 @default.
• W2116697914 cites W2036212440 @default.
• W2116697914 cites W2037232466 @default.
• W2116697914 cites W2041357642 @default.
• W2116697914 cites W2041644816 @default.
• W2116697914 cites W2042071333 @default.
• W2116697914 cites W2051806608 @default.
• W2116697914 cites W2053569929 @default.
• W2116697914 cites W2054096599 @default.
• W2116697914 cites W2060013854 @default.
• W2116697914 cites W2060403663 @default.
• W2116697914 cites W2062297552 @default.
• W2116697914 cites W2066664485 @default.
• W2116697914 cites W2071310612 @default.
• W2116697914 cites W2071658009 @default.
• W2116697914 cites W2075910471 @default.
• W2116697914 cites W2076565277 @default.
• W2116697914 cites W2076665586 @default.
• W2116697914 cites W2091076367 @default.
• W2116697914 cites W2092223809 @default.
• W2116697914 cites W2093070695 @default.
• W2116697914 cites W2104722838 @default.
• W2116697914 cites W2107392208 @default.
• W2116697914 cites W2113901744 @default.
• W2116697914 cites W2116742009 @default.
• W2116697914 cites W2125617083 @default.
• W2116697914 cites W2128248793 @default.
• W2116697914 cites W2128477717 @default.
• W2116697914 cites W2136568760 @default.
• W2116697914 cites W2147448522 @default.
• W2116697914 cites W2158604085 @default.
• W2116697914 cites W2172344659 @default.
• W2116697914 cites W2272757036 @default.
• W2116697914 cites W2325825173 @default.
• W2116697914 cites W2337686867 @default.
• W2116697914 cites W2339290868 @default.
• W2116697914 cites W4250058955 @default.
• W2116697914 cites W4255304452 @default.
• W2116697914 cites W4296766361 @default.
• W2116697914 cites W4323874780 @default.
• W2116697914 cites W4384272988 @default.
• W2116697914 doi "https://doi.org/10.1517/14656566.3.6.643" @default.
• W2116697914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12472080" @default.
• W2116697914 hasPublicationYear "2002" @default.
• W2116697914 type Work @default.
• W2116697914 sameAs 2116697914 @default.
• W2116697914 citedByCount "57" @default.
• W2116697914 countsByYear W21166979142012 @default.
• W2116697914 countsByYear W21166979142013 @default.
• W2116697914 countsByYear W21166979142014 @default.
• W2116697914 countsByYear W21166979142015 @default.
• W2116697914 countsByYear W21166979142016 @default.
• W2116697914 countsByYear W21166979142017 @default.
• W2116697914 countsByYear W21166979142020 @default.
• W2116697914 crossrefType "journal-article" @default.
• W2116697914 hasAuthorship W2116697914A5013799194 @default.

• next