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- W2116700965 abstract "ABSTRACT T-cell development is under the tight control of thymic microenvironments. Conversely, the integrity of thymic microenvironments depends on the physical presence of developing thymocytes, a phenomenon designated as ‘thymic crosstalk’. We now show, using three types of immunodeficient mice, i.e. CD3ε transgenic mice, RAGnull mice and RAGnull-bone-marrow-transplanted CD3ε transgenic mice, that the control point in lymphoid development where triple negative (CD3−,CD4−,CD8−) thymocytes progress from CD44+CD25− towards CD44− CD25+, influences the development of epithelial cells, critically inducing the extra, third dimension in the organization of the epithelial cells in the cortex. This tertiary configuration of the thymic epithelium is a typical feature for the thymus, enabling lymphostromal interaction during T-cell development. Crosstalk signals at this control point also induce the formation of thymic nurse cells. Moreover, our data indicate that establishment of a thymic cortex is a prerequisite for the development of the thymic medulla. Thus, differentiating thymocytes regulate the morphogenesis of thymic microenvironments in a stepwise fashion." @default.
- W2116700965 created "2016-06-24" @default.
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- W2116700965 date "2000-04-15" @default.
- W2116700965 modified "2023-10-01" @default.
- W2116700965 title "Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets" @default.
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- W2116700965 doi "https://doi.org/10.1242/dev.127.8.1583" @default.
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