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- W2116701268 abstract "p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India.Genotype frequencies at the three p53 loci in 110 controls and 79 oral cancer cases were determined by the PCR-RFLP method.Heterozygous individuals at exon 4 showed protection from developing oral cancer. Homozygous wild and heterozygous individuals at intron 3 and those heterozygous at exon 4 in combination appeared to be at lowered risk. Furthermore, carriers of the 16 bp duplication allele at intron 3, proline allele at exon 4 and G allele at intron 6 were protected from oral cancer development.p53 polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer development in Gujarat, West Indian population." @default.
- W2116701268 created "2016-06-24" @default.
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- W2116701268 date "2013-02-28" @default.
- W2116701268 modified "2023-09-27" @default.
- W2116701268 title "Association between p53 Gene Variants and Oral Cancer Susceptibility in Population from Gujarat, West India" @default.
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- W2116701268 doi "https://doi.org/10.7314/apjcp.2013.14.2.1093" @default.
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