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• W2116701298 startingPage "1361" @default.
• W2116701298 abstract "In nonrecombining genomes, genetic linkage can be an important evolutionary force. Linkage generates interference interactions, by which simultaneously occurring mutations affect each other's chance of fixation. Here, we develop a comprehensive model of adaptive evolution in linked genomes, which integrates interference interactions between multiple beneficial and deleterious mutations into a unified framework. By an approximate analytical solution, we predict the fixation rates of these mutations, as well as the probabilities of beneficial and deleterious alleles at fixed genomic sites. We find that interference interactions generate a regime of emergent neutrality: all genomic sites with selection coefficients smaller in magnitude than a characteristic threshold have nearly random fixed alleles, and both beneficial and deleterious mutations at these sites have nearly neutral fixation rates. We show that this dynamic limits not only the speed of adaptation, but also a population's degree of adaptation in its current environment. We apply the model to different scenarios: stationary adaptation in a time-dependent environment and approach to equilibrium in a fixed environment. In both cases, the analytical predictions are in good agreement with numerical simulations. Our results suggest that interference can severely compromise biological functions in an adapting population, which sets viability limits on adaptive evolution under linkage." @default.
• W2116701298 created "2016-06-24" @default.
• W2116701298 creator A5041978316 @default.
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• W2116701298 creator A5061483267 @default.
• W2116701298 creator A5061995455 @default.
• W2116701298 date "2011-12-01" @default.
• W2116701298 modified "2023-10-17" @default.
• W2116701298 title "Emergent Neutrality in Adaptive Asexual Evolution" @default.
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• W2116701298 doi "https://doi.org/10.1534/genetics.111.132027" @default.
• W2116701298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3241435" @default.
• W2116701298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21926305" @default.
• W2116701298 hasPublicationYear "2011" @default.
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