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- W2116702901 abstract "Enteroviruses have been associated with type 1 diabetes mellitus (T1DM), but it is unclear whether there is a distinct disease subtype. Plasma and stool samples from 206 consecutively diagnosed children and 160 healthy control children were analyzed by reverse-transcription polymerase chain reaction for the RNA of 60 enteroviruses. More children with diabetes tested positive for enterovirus RNA (30% vs. 4%; odds ratio, 11.1; 95% confidence interval, 4.7-25.7; P<.001). Enterovirus 71 was detected in 25% of children; these were temporally associated with outbreaks in Southeast Asia and Australia. Fewer children with the diabetes-associated human leukocyte antigen DRB1*03-DQB1*02 genotype tested positive for enterovirus RNA (P=.02). More children presenting with severe diabetic ketoacidosis (pH, <7.1) tested positive for enterovirus RNA (P=.04). These results suggest that there is a subgroup of patients with T1DM, who are at low genetic risk, in whom enteroviruses contribute to diabetes onset." @default.
- W2116702901 created "2016-06-24" @default.
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- W2116702901 date "2003-05-15" @default.
- W2116702901 modified "2023-10-06" @default.
- W2116702901 title "Reduced Frequency of HLA DRB1*03‐DQB1*02 in Children with Type 1 Diabetes Associated with Enterovirus RNA" @default.
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- W2116702901 doi "https://doi.org/10.1086/374742" @default.
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