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- W2116711303 abstract "BACKGROUND In this study, defined culture conditions were used to examine the effects of recombinant TGFβ1 on prostatic stromal cells and to determine the role of endogenous TGFβ produced by these cells. METHODS Cells were grown +/− recombinant TGFβ1 and cell population sizes in replicate cultures determined. In other experiments, TGFβ1 production by prostatic stromal cells was examined and the effects of neutralization of this activity on cell population sizes and apoptosis evaluated. RESULTS At > 1 ng/ml, TGFβ1 reduced cell population sizes while at 0.01 ng/ml cell numbers were increased cf. controls. Stromal cells produced up to 10 ng/ml/48 hr of latent TGFβ1 of which < 0.2% was biologically active. When cells were treated with anti-TGFβ1 antibodies, cell numbers decreased cf. controls and the proportion of apoptotic cells increased. CONCLUSIONS These observations suggest that TGFβ1 is an autocrine factor made by prostatic stromal cells in which it inhibits apoptosis at the activity levels produced. Prostate 48:297–304, 2001. © 2001 Wiley-Liss, Inc." @default.
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- W2116711303 date "2001-01-01" @default.
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- W2116711303 title "Role of endogenous transforming growth factor ? (TGF?) 1 in prostatic stromal cells" @default.
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- W2116711303 doi "https://doi.org/10.1002/pros.1110" @default.
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