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• W2116711603 abstract "The podocyte is one of the two cell types that contribute to the formation of the glomerular filtration barrier (GFB). It is a highly specialized cell with a unique structure. The key feature of the podocyte is its foot processes that regularly interdigitate. A structure known as the slit diaphragm can be found bridging the interdigitations. This molecular sieve comprises the final layer of the GFB. It is well accepted that the podocyte is the target cell in the pathogenesis of nephrotic syndrome. In nephrotic syndrome, the GFB no longer restricts the passage of macromolecules and protein is lost into the urine. A number of phenotypic and morphological changes are seen in the diseased podocyte and in the literature these have been described as an epithelial-mesenchymal transition (EMT). However, there is a growing appreciation that this term does not accurately describe the changes that are seen. Definitions of type-2 EMT are based on typical epithelial cells. While the podocyte is known as a visceral epithelial cell, it is not a typical epithelial cell. Moreover, podocytes have several features that are more consistent with mesenchymal cells. Therefore, we suggest that the term podocyte disease transformation is more appropriate." @default.
• W2116711603 created "2016-06-24" @default.
• W2116711603 creator A5026207697 @default.
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• W2116711603 date "2014-10-01" @default.
• W2116711603 modified "2023-10-14" @default.
• W2116711603 title "Podocyte Dedifferentiation: A Specialized Process for a Specialized Cell" @default.
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• W2116711603 doi "https://doi.org/10.3389/fendo.2014.00148" @default.
• W2116711603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4181233" @default.
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