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• W2116712689 abstract "In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although 2 H 2 O labeling in young mice showed high thymic-dependent daily naïve T cell production, long term up- and down-labeling with 2 H 2 O in human adults revealed a low daily production of naïve T cells. Using mathematical modeling, we estimated human naïve CD4 and CD8 T cell half-lives of 4.2 and 6.5 years, respectively, whereas memory CD4 and CD8 T cells had half-lives of 0.4 and 0.7 year. The estimated half-life of recently produced naïve T cells was much longer than these average half-lives. Thus, our data are incompatible with a substantial short-lived RTE population in human adults and suggest that the few naïve T cells that are newly produced are preferentially incorporated in the peripheral pool." @default.
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• W2116712689 date "2008-04-22" @default.
• W2116712689 modified "2023-09-26" @default.
• W2116712689 title "Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool" @default.
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• W2116712689 doi "https://doi.org/10.1073/pnas.0709713105" @default.
• W2116712689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2329696" @default.
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