FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116714438> ?p ?o ?g. }

• W2116714438 endingPage "5323" @default.
• W2116714438 startingPage "5309" @default.
• W2116714438 abstract "The Ire1p transmembrane receptor kinase/endonuclease transduces the unfolded protein response (UPR) from the endoplasmic reticulum (ER) to the nucleus in Saccharomyces cerevisiae. In this study, we analyzed the capacity of a highly basic sequence in the linker region of Ire1p to function as a nuclear localization sequence (NLS) both in vivo and in vitro. This 18-residue sequence is capable of targeting green fluorescent protein to the nucleus of yeast cells in a process requiring proteins involved in the Ran GTPase cycle that facilitates nuclear import. Mutagenic analysis and importin binding studies demonstrate that the Ire1p linker region contains overlapping potential NLSs: at least one classical NLS (within sequences 642 KKKRKR 647 and/or 653 KKGR 656 ) that is recognized by yeast importin α (Kap60p) and a novel βNLS ( 646 KRGSRGGKKGRK 657 ) that is recognized by several yeast importin β homologues. Kinetic binding data suggest that binding to importin β proteins would predominate in vivo. The UPR, and in particular ER stress-induced HAC1 mRNA splicing, is inhibited by point mutations in the Ire1p NLS that inhibit nuclear localization and also requires functional RanGAP and Ran GEF proteins. The NLS-dependent nuclear localization of Ire1p would thus seem to be central to its role in UPR signaling." @default.
• W2116714438 created "2016-06-24" @default.
• W2116714438 creator A5003869776 @default.
• W2116714438 creator A5022995714 @default.
• W2116714438 creator A5024580932 @default.
• W2116714438 creator A5026688968 @default.
• W2116714438 creator A5031792222 @default.
• W2116714438 creator A5038739529 @default.
• W2116714438 creator A5046439531 @default.
• W2116714438 creator A5070182251 @default.
• W2116714438 creator A5079759294 @default.
• W2116714438 creator A5081383005 @default.
• W2116714438 creator A5085282433 @default.
• W2116714438 creator A5087859961 @default.
• W2116714438 date "2006-12-01" @default.
• W2116714438 modified "2023-09-26" @default.
• W2116714438 title "The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple β Importins" @default.
• W2116714438 cites W104341128 @default.
• W2116714438 cites W1480534106 @default.
• W2116714438 cites W1970711633 @default.
• W2116714438 cites W1978838832 @default.
• W2116714438 cites W1984354326 @default.
• W2116714438 cites W1985268943 @default.
• W2116714438 cites W1985841255 @default.
• W2116714438 cites W1989344763 @default.
• W2116714438 cites W1990400035 @default.
• W2116714438 cites W1994148031 @default.
• W2116714438 cites W1994234356 @default.
• W2116714438 cites W1995847246 @default.
• W2116714438 cites W1997160430 @default.
• W2116714438 cites W1999213132 @default.
• W2116714438 cites W2002439304 @default.
• W2116714438 cites W2004937148 @default.
• W2116714438 cites W2015288395 @default.
• W2116714438 cites W2017284082 @default.
• W2116714438 cites W2020437934 @default.
• W2116714438 cites W2023788610 @default.
• W2116714438 cites W2026470786 @default.
• W2116714438 cites W2027078124 @default.
• W2116714438 cites W2027981450 @default.
• W2116714438 cites W2029852810 @default.
• W2116714438 cites W2030574146 @default.
• W2116714438 cites W2033324724 @default.
• W2116714438 cites W2036931150 @default.
• W2116714438 cites W2038763220 @default.
• W2116714438 cites W2039999119 @default.
• W2116714438 cites W2040993603 @default.
• W2116714438 cites W2043014850 @default.
• W2116714438 cites W2045309657 @default.
• W2116714438 cites W2046640957 @default.
• W2116714438 cites W2047201865 @default.
• W2116714438 cites W2049132410 @default.
• W2116714438 cites W2051665782 @default.
• W2116714438 cites W2053296976 @default.
• W2116714438 cites W2053796273 @default.
• W2116714438 cites W2055189297 @default.
• W2116714438 cites W2055836716 @default.
• W2116714438 cites W2081294646 @default.
• W2116714438 cites W2083445344 @default.
• W2116714438 cites W2084692950 @default.
• W2116714438 cites W2086725260 @default.
• W2116714438 cites W2088228878 @default.
• W2116714438 cites W2090839709 @default.
• W2116714438 cites W2094082493 @default.
• W2116714438 cites W2103755904 @default.
• W2116714438 cites W2106314483 @default.
• W2116714438 cites W2106983618 @default.
• W2116714438 cites W2110826944 @default.
• W2116714438 cites W2111312305 @default.
• W2116714438 cites W2115137627 @default.
• W2116714438 cites W2120949831 @default.
• W2116714438 cites W2123110333 @default.
• W2116714438 cites W2124682700 @default.
• W2116714438 cites W2133201628 @default.
• W2116714438 cites W2135450099 @default.
• W2116714438 cites W2137755719 @default.
• W2116714438 cites W2138707293 @default.
• W2116714438 cites W2144065739 @default.
• W2116714438 cites W2147065993 @default.
• W2116714438 cites W2149290547 @default.
• W2116714438 cites W2151456368 @default.
• W2116714438 cites W2159175279 @default.
• W2116714438 cites W2162076197 @default.
• W2116714438 cites W2162226086 @default.
• W2116714438 cites W2162797237 @default.
• W2116714438 cites W2165306451 @default.
• W2116714438 cites W2169805130 @default.
• W2116714438 cites W2171788412 @default.
• W2116714438 cites W2192080449 @default.
• W2116714438 cites W2209964471 @default.
• W2116714438 cites W2316964745 @default.
• W2116714438 cites W315837935 @default.
• W2116714438 cites W4244436610 @default.
• W2116714438 cites W4248136323 @default.
• W2116714438 cites W4250374989 @default.
• W2116714438 cites W4294232809 @default.
• W2116714438 doi "https://doi.org/10.1091/mbc.e06-04-0292" @default.
• W2116714438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1679693" @default.

• next