FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116715404> ?p ?o ?g. }

• W2116715404 endingPage "298" @default.
• W2116715404 startingPage "276" @default.
• W2116715404 abstract "Inhibiting leukocyte recruitment is now a major focus in the design of novel anti-inflammatory drugs. Following the identification of lead compounds from conventional high-throughput screens using appropriate receptors or enzymes, it is important to validate the action of the compounds in a suitable in vitro model of leukocyte migration. Here, we review a range of different experimental approaches to modelling leukocyte migration, and identify the multi-well filter migration assay as the best compromise between the amount of resources required to screen multiple compounds and the amount of information gained about the effects of the compounds on cell movement behavior. However, there are pitfalls in the interpretation of data obtained using the multi-well filter migration assay, which arise from the imperfect correlation between the number of cells undergoing migration and the inhibitory activity of the test substances. We examine a number of such pitfalls and provide practical approaches to mitigate these problems as far as possible. We recommend a general strategy for screening inhibitors of cell migration using in vitro functional assays. While being more resource intensive than surrogate measures such as calcium flux, functional approaches nevertheless provide superior correlations with anti-inflammatory activity in vivo." @default.
• W2116715404 created "2016-06-24" @default.
• W2116715404 creator A5047996229 @default.
• W2116715404 creator A5059795686 @default.
• W2116715404 creator A5068491158 @default.
• W2116715404 date "2004-01-01" @default.
• W2116715404 modified "2023-10-12" @default.
• W2116715404 title "Tools for anti-inflammatory drug design:In vitro models of leukocyte migration" @default.
• W2116715404 cites W107153115 @default.
• W2116715404 cites W1413329771 @default.
• W2116715404 cites W1485881176 @default.
• W2116715404 cites W1499048493 @default.
• W2116715404 cites W1504312997 @default.
• W2116715404 cites W1510633975 @default.
• W2116715404 cites W1541709451 @default.
• W2116715404 cites W1543575007 @default.
• W2116715404 cites W1544492328 @default.
• W2116715404 cites W1548455476 @default.
• W2116715404 cites W1556201258 @default.
• W2116715404 cites W1574813722 @default.
• W2116715404 cites W1602000691 @default.
• W2116715404 cites W1602835962 @default.
• W2116715404 cites W1664603782 @default.
• W2116715404 cites W171426009 @default.
• W2116715404 cites W1778576079 @default.
• W2116715404 cites W1901808362 @default.
• W2116715404 cites W1915267836 @default.
• W2116715404 cites W1963873817 @default.
• W2116715404 cites W1963984954 @default.
• W2116715404 cites W1971505103 @default.
• W2116715404 cites W1973775002 @default.
• W2116715404 cites W1974573786 @default.
• W2116715404 cites W1978201079 @default.
• W2116715404 cites W1984561421 @default.
• W2116715404 cites W1991414321 @default.
• W2116715404 cites W1992133263 @default.
• W2116715404 cites W1994415948 @default.
• W2116715404 cites W1998819077 @default.
• W2116715404 cites W1999876918 @default.
• W2116715404 cites W2000377675 @default.
• W2116715404 cites W2002942416 @default.
• W2116715404 cites W2003492631 @default.
• W2116715404 cites W2005216911 @default.
• W2116715404 cites W2005659566 @default.
• W2116715404 cites W2006717761 @default.
• W2116715404 cites W2008809719 @default.
• W2116715404 cites W2009355356 @default.
• W2116715404 cites W2014984654 @default.
• W2116715404 cites W2017289418 @default.
• W2116715404 cites W2020402787 @default.
• W2116715404 cites W2021771515 @default.
• W2116715404 cites W2021877641 @default.
• W2116715404 cites W2023213942 @default.
• W2116715404 cites W2023528999 @default.
• W2116715404 cites W2027344845 @default.
• W2116715404 cites W2028959499 @default.
• W2116715404 cites W2030279593 @default.
• W2116715404 cites W2036672952 @default.
• W2116715404 cites W2037458332 @default.
• W2116715404 cites W2039259555 @default.
• W2116715404 cites W2043356982 @default.
• W2116715404 cites W2045810087 @default.
• W2116715404 cites W2046634295 @default.
• W2116715404 cites W2047719515 @default.
• W2116715404 cites W2056432376 @default.
• W2116715404 cites W2057093848 @default.
• W2116715404 cites W205821215 @default.
• W2116715404 cites W2059009993 @default.
• W2116715404 cites W2061866937 @default.
• W2116715404 cites W2061980700 @default.
• W2116715404 cites W2062199188 @default.
• W2116715404 cites W2064823163 @default.
• W2116715404 cites W2066882388 @default.
• W2116715404 cites W2069348092 @default.
• W2116715404 cites W2072548924 @default.
• W2116715404 cites W2074430638 @default.
• W2116715404 cites W2074438676 @default.
• W2116715404 cites W2075702611 @default.
• W2116715404 cites W2075713267 @default.
• W2116715404 cites W2076348113 @default.
• W2116715404 cites W2078186712 @default.
• W2116715404 cites W2081987371 @default.
• W2116715404 cites W2082402714 @default.
• W2116715404 cites W2083263336 @default.
• W2116715404 cites W2083788792 @default.
• W2116715404 cites W2086214338 @default.
• W2116715404 cites W2088557737 @default.
• W2116715404 cites W2089590606 @default.
• W2116715404 cites W2092868899 @default.
• W2116715404 cites W2093482698 @default.
• W2116715404 cites W2097646128 @default.
• W2116715404 cites W2099675490 @default.
• W2116715404 cites W2099850307 @default.
• W2116715404 cites W2100330873 @default.
• W2116715404 cites W2103685679 @default.
• W2116715404 cites W2104918497 @default.
• W2116715404 cites W2104923755 @default.
• W2116715404 cites W2114068014 @default.

• next