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- W2116715712 abstract "ABSTRACT Porphyromonas gingivalis cysteine proteinases (gingipains) have been associated with virulence in destructive periodontitis, a disease process variously considered to represent an unregulated stimulation of either T helper type 1 (Th1)- or Th2-type cells. Critical in maintaining Th1 activity is the response of T lymphocytes to environmental interleukin 12 (IL-12) in the form of up-regulation of gamma interferon (IFN-γ) production. Here we demonstrate that in the presence or absence of serum, gingipains were able to hydrolyze IL-12 and reduce the IL-12-induced IFN-γ production from CD4 + T cells. However, the induction of IL-12 receptors on T cells by gingipains did not correlate with the enhancement of IFN-γ production. The gingipains cleaved IL-12 within the COOH-terminal region of the p40 and p35 subunit chains, which leads to IL-12 inactivity, whereas IL-2 in these assays was not affected. Inactivation of IL-12 by the gingipains could disrupt the cytokine balance or favor Th2 activities in the progression of periodontitis." @default.
- W2116715712 created "2016-06-24" @default.
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- W2116715712 creator A5024087080 @default.
- W2116715712 creator A5026815496 @default.
- W2116715712 creator A5058024941 @default.
- W2116715712 date "2001-09-01" @default.
- W2116715712 modified "2023-10-13" @default.
- W2116715712 title "Hydrolysis of Interleukin-12 by<i>Porphyromonas gingivalis</i>Major Cysteine Proteinases May Affect Local Gamma Interferon Accumulation and the Th1 or Th2 T-Cell Phenotype in Periodontitis" @default.
- W2116715712 cites W1481829434 @default.
- W2116715712 cites W1502025481 @default.
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- W2116715712 cites W1567298925 @default.
- W2116715712 cites W1574030303 @default.
- W2116715712 cites W1595536772 @default.
- W2116715712 cites W1629179716 @default.
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- W2116715712 cites W1972922050 @default.
- W2116715712 cites W1973512297 @default.
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- W2116715712 doi "https://doi.org/10.1128/iai.69.9.5650-5660.2001" @default.
- W2116715712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/98681" @default.
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