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• W2116716017 endingPage "1186" @default.
• W2116716017 startingPage "1183" @default.
• W2116716017 abstract "It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3-CD11c- plasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-gamma. Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset." @default.
• W2116716017 created "2016-06-24" @default.
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• W2116716017 date "1999-02-19" @default.
• W2116716017 modified "2023-10-18" @default.
• W2116716017 title "Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation" @default.
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• W2116716017 doi "https://doi.org/10.1126/science.283.5405.1183" @default.
• W2116716017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10024247" @default.
• W2116716017 hasPublicationYear "1999" @default.
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