Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116716614> ?p ?o ?g. }
- W2116716614 endingPage "614" @default.
- W2116716614 startingPage "605" @default.
- W2116716614 abstract "ABSTRACT Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV. We show that human APOBEC3G is a potent inhibitor of FV infectivity in cell culture experiments. This antiviral activity is associated with cytidine editing of the viral genome. Both molecular FV clones and primary uncloned viruses were susceptible to APOBEC3G, and viral infectivity was also inhibited by murine and simian APOBEC3G homologues, as well as by human APOBEC3F. Wild-type and bet -deleted viruses were similarly sensitive to this antiviral activity, suggesting that Bet does not significantly counteract APOBEC proteins. Moreover, we did not detect FV sequences that may have been targeted by APOBEC in naturally infected macaques, but we observed a few G-to-A substitutions in humans that have been accidentally contaminated by simian FV. In infected hosts, the persistence strategy employed by FV might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases." @default.
- W2116716614 created "2016-06-24" @default.
- W2116716614 creator A5002582659 @default.
- W2116716614 creator A5008203751 @default.
- W2116716614 creator A5013201108 @default.
- W2116716614 creator A5023493533 @default.
- W2116716614 creator A5036857910 @default.
- W2116716614 creator A5048231044 @default.
- W2116716614 creator A5055664477 @default.
- W2116716614 creator A5076494909 @default.
- W2116716614 creator A5087833364 @default.
- W2116716614 creator A5090166080 @default.
- W2116716614 date "2006-01-15" @default.
- W2116716614 modified "2023-10-18" @default.
- W2116716614 title "Restriction of Foamy Viruses by APOBEC Cytidine Deaminases" @default.
- W2116716614 cites W1485334461 @default.
- W2116716614 cites W1486926654 @default.
- W2116716614 cites W1526019461 @default.
- W2116716614 cites W1619678312 @default.
- W2116716614 cites W1640130878 @default.
- W2116716614 cites W166593606 @default.
- W2116716614 cites W1668032639 @default.
- W2116716614 cites W1905921278 @default.
- W2116716614 cites W1910893289 @default.
- W2116716614 cites W1935340730 @default.
- W2116716614 cites W1943367649 @default.
- W2116716614 cites W1965048581 @default.
- W2116716614 cites W1965353962 @default.
- W2116716614 cites W1966343819 @default.
- W2116716614 cites W1972873427 @default.
- W2116716614 cites W1975484222 @default.
- W2116716614 cites W1990993204 @default.
- W2116716614 cites W1991437670 @default.
- W2116716614 cites W1992984336 @default.
- W2116716614 cites W1993897877 @default.
- W2116716614 cites W1995117749 @default.
- W2116716614 cites W2000620255 @default.
- W2116716614 cites W2001375348 @default.
- W2116716614 cites W2002569845 @default.
- W2116716614 cites W2004640739 @default.
- W2116716614 cites W2007978409 @default.
- W2116716614 cites W2010462699 @default.
- W2116716614 cites W2012564250 @default.
- W2116716614 cites W2016732725 @default.
- W2116716614 cites W2023749753 @default.
- W2116716614 cites W2032323486 @default.
- W2116716614 cites W2033464993 @default.
- W2116716614 cites W2040313539 @default.
- W2116716614 cites W2042486230 @default.
- W2116716614 cites W2049930242 @default.
- W2116716614 cites W2052219130 @default.
- W2116716614 cites W2054437592 @default.
- W2116716614 cites W2056832684 @default.
- W2116716614 cites W2063337242 @default.
- W2116716614 cites W2063339794 @default.
- W2116716614 cites W2063886057 @default.
- W2116716614 cites W2070267873 @default.
- W2116716614 cites W2073978153 @default.
- W2116716614 cites W2074247685 @default.
- W2116716614 cites W2076441216 @default.
- W2116716614 cites W2080316262 @default.
- W2116716614 cites W2080527819 @default.
- W2116716614 cites W2081131167 @default.
- W2116716614 cites W2096363667 @default.
- W2116716614 cites W2097745684 @default.
- W2116716614 cites W2098183178 @default.
- W2116716614 cites W2100883308 @default.
- W2116716614 cites W2104171891 @default.
- W2116716614 cites W2108102500 @default.
- W2116716614 cites W2111079470 @default.
- W2116716614 cites W2117335313 @default.
- W2116716614 cites W2118197250 @default.
- W2116716614 cites W2120359704 @default.
- W2116716614 cites W2120463956 @default.
- W2116716614 cites W2126851178 @default.
- W2116716614 cites W2128204555 @default.
- W2116716614 cites W2133389565 @default.
- W2116716614 cites W2139033519 @default.
- W2116716614 cites W2140043551 @default.
- W2116716614 cites W2141715522 @default.
- W2116716614 cites W2147059663 @default.
- W2116716614 cites W2149643442 @default.
- W2116716614 cites W2157876432 @default.
- W2116716614 cites W2158491318 @default.
- W2116716614 cites W2158851809 @default.
- W2116716614 cites W2167917127 @default.
- W2116716614 cites W2168421974 @default.
- W2116716614 cites W2473254556 @default.
- W2116716614 cites W30525310 @default.
- W2116716614 cites W4232273699 @default.
- W2116716614 cites W4238634254 @default.
- W2116716614 doi "https://doi.org/10.1128/jvi.80.2.605-614.2006" @default.
- W2116716614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1346872" @default.
- W2116716614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16378963" @default.
- W2116716614 hasPublicationYear "2006" @default.
- W2116716614 type Work @default.
- W2116716614 sameAs 2116716614 @default.
- W2116716614 citedByCount "131" @default.