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- W2116717324 abstract "Flow cytometry was used to study phagocytic function and release of reactive oxygen products following phagocytosis by neutrophils (PMNL) and monocytes of heparinized whole blood from stage 1 human immunodeficiency virus type 1 (HIV-1)-infected men. Phagocytic capacity was assessed by measuring uptake of Texas red-labeled bacteria. Reactive oxygen generation after phagocytosis was estimated by the quantity of dichlorofluorescein diacetate converted to dichlorofluorescein intracellularly. Compared with results in samples from age- and sex-matched controls, PMNL and monocytes from HIV-1-infected patients exhibited a significantly increased capacity to phagocytose Staphylococcus aureus and Escherichia coli and generate reactive oxygen products. These results are consistent with the hypothesis that stimuli associated with early HIV-1 infection enhance the nonspecific response of phagocytic cells to potential bacterial pathogens." @default.
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- W2116717324 date "1993-07-01" @default.
- W2116717324 modified "2023-10-17" @default.
- W2116717324 title "Increased Phagocytosis and Generation of Reactive Oxygen Products by Neutrophils and Monocytes of Men with Stage 1 Human Immunodeficiency Virus Infection" @default.
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- W2116717324 doi "https://doi.org/10.1093/infdis/168.1.75" @default.
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