FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116718517> ?p ?o ?g. }

• W2116718517 endingPage "6" @default.
• W2116718517 startingPage "763" @default.
• W2116718517 abstract "Oxytocin antagonist (OTA), TT-235, was developed by our group and shown to inhibit either spontaneous or oxytocin-induced uterine contractions in primates. The purpose of the present study was to confirm the duration of TT-235 to block oxytocin-induced uterine contractions in estrous rats. In Experiment 1, the time-response of the three OTAs on uterine contractility was examined. The rats were anesthetized and cannulas were placed in the jugular vein for infusing vehicle (sterile saline), Antag I, Antag II and TT-235. The uterine activity was monitored through a water-filled balloon-tipped cannula placed in the uterine horn. The uterine contractile activity was determined as the integrated area for 10 minutes. Each OTA was administered as a single bolus injection of 5 microg, followed by 100 mU of oxytocin 5 minutes later, also done as a single bolus. Oxytocin injection of the same dosage was repeated every hour for 5 hours. Experiment 2 determined the effect of the three OTAs on uterine oxytocin receptor number (Rn) and binding affinity (Kd). Rats treated with either OTA or vehicle were sacrificed at 0.5 and 4 hours for receptor assay. In Experiment 1, Antag I, Antag II and TT-235 inhibited the integrated uterine response to oxytocin at 5 minutes by 76%, 77% and 80%, respectively, compared to controls (p<0.05). Two hours after injecting Antag I, inhibition of uterine contractility was 55% lower than controls (p<0.05). At 3 hours, uterine contractility was no longer affected in rats treated with Antag I compared with controls. The suppressive uterine activity with Antag II continued up to 3 hours. However, uterine contractility remained lower (53%) in rats treated with TT-235 5 hours later. In Experiment 2, TT-235 induced a significant decrease (p<0.05) in oxytocin receptor number and binding affinity at both 0.5 and 4 hours compared with controls. Antag I and Antag II did not alter oxytocin receptor number or binding affinity significantly at each time point studied compared with controls. In conclusion, TT-235 may inhibit the uterine response to oxytocin by decreasing oxytocin receptor numbers and oxytocin binding affinity, which might explain the prolonged oxytocin antagonist activity of TT-235." @default.
• W2116718517 created "2016-06-24" @default.
• W2116718517 creator A5023957312 @default.
• W2116718517 creator A5026357365 @default.
• W2116718517 creator A5045017851 @default.
• W2116718517 creator A5046441121 @default.
• W2116718517 creator A5057333101 @default.
• W2116718517 creator A5076189720 @default.
• W2116718517 date "2005-01-14" @default.
• W2116718517 modified "2023-09-25" @default.
• W2116718517 title "In vivo activity of the potent oxytocin antagonist on uterine activity in the rat." @default.
• W2116718517 cites W1975276469 @default.
• W2116718517 cites W1979289201 @default.
• W2116718517 cites W2002622327 @default.
• W2116718517 cites W2007844076 @default.
• W2116718517 cites W2030556522 @default.
• W2116718517 cites W2040237541 @default.
• W2116718517 cites W2076390206 @default.
• W2116718517 cites W2088408613 @default.
• W2116718517 cites W2092556639 @default.
• W2116718517 cites W2096157259 @default.
• W2116718517 cites W2097144097 @default.
• W2116718517 cites W2105440398 @default.
• W2116718517 cites W2114374730 @default.
• W2116718517 cites W2117763597 @default.
• W2116718517 cites W2145048555 @default.
• W2116718517 cites W2145966704 @default.
• W2116718517 cites W2152096508 @default.
• W2116718517 cites W2155648994 @default.
• W2116718517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15646817" @default.
• W2116718517 hasPublicationYear "2005" @default.
• W2116718517 type Work @default.
• W2116718517 sameAs 2116718517 @default.
• W2116718517 citedByCount "1" @default.
• W2116718517 countsByYear W21167185172019 @default.
• W2116718517 crossrefType "journal-article" @default.
• W2116718517 hasAuthorship W2116718517A5023957312 @default.
• W2116718517 hasAuthorship W2116718517A5026357365 @default.
• W2116718517 hasAuthorship W2116718517A5045017851 @default.
• W2116718517 hasAuthorship W2116718517A5046441121 @default.
• W2116718517 hasAuthorship W2116718517A5057333101 @default.
• W2116718517 hasAuthorship W2116718517A5076189720 @default.
• W2116718517 hasConcept C126322002 @default.
• W2116718517 hasConcept C134018914 @default.
• W2116718517 hasConcept C141071460 @default.
• W2116718517 hasConcept C170493617 @default.
• W2116718517 hasConcept C181612422 @default.
• W2116718517 hasConcept C2776176026 @default.
• W2116718517 hasConcept C2776766599 @default.
• W2116718517 hasConcept C2776885963 @default.
• W2116718517 hasConcept C2777397205 @default.
• W2116718517 hasConcept C2778074680 @default.
• W2116718517 hasConcept C2778227567 @default.
• W2116718517 hasConcept C2779066055 @default.
• W2116718517 hasConcept C39133596 @default.
• W2116718517 hasConcept C43376680 @default.
• W2116718517 hasConcept C71924100 @default.
• W2116718517 hasConceptScore W2116718517C126322002 @default.
• W2116718517 hasConceptScore W2116718517C134018914 @default.
• W2116718517 hasConceptScore W2116718517C141071460 @default.
• W2116718517 hasConceptScore W2116718517C170493617 @default.
• W2116718517 hasConceptScore W2116718517C181612422 @default.
• W2116718517 hasConceptScore W2116718517C2776176026 @default.
• W2116718517 hasConceptScore W2116718517C2776766599 @default.
• W2116718517 hasConceptScore W2116718517C2776885963 @default.
• W2116718517 hasConceptScore W2116718517C2777397205 @default.
• W2116718517 hasConceptScore W2116718517C2778074680 @default.
• W2116718517 hasConceptScore W2116718517C2778227567 @default.
• W2116718517 hasConceptScore W2116718517C2779066055 @default.
• W2116718517 hasConceptScore W2116718517C39133596 @default.
• W2116718517 hasConceptScore W2116718517C43376680 @default.
• W2116718517 hasConceptScore W2116718517C71924100 @default.
• W2116718517 hasIssue "6" @default.
• W2116718517 hasLocation W21167185171 @default.
• W2116718517 hasOpenAccess W2116718517 @default.
• W2116718517 hasPrimaryLocation W21167185171 @default.
• W2116718517 hasRelatedWork W1981195487 @default.
• W2116718517 hasRelatedWork W2012105162 @default.
• W2116718517 hasRelatedWork W2030556522 @default.
• W2116718517 hasRelatedWork W2038160024 @default.
• W2116718517 hasRelatedWork W2070052847 @default.
• W2116718517 hasRelatedWork W2095512730 @default.
• W2116718517 hasRelatedWork W2116718517 @default.
• W2116718517 hasRelatedWork W2160002861 @default.
• W2116718517 hasRelatedWork W2408453752 @default.
• W2116718517 hasRelatedWork W2461593405 @default.
• W2116718517 hasVolume "18" @default.
• W2116718517 isParatext "false" @default.
• W2116718517 isRetracted "false" @default.
• W2116718517 magId "2116718517" @default.
• W2116718517 workType "article" @default.