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- W2116718742 abstract "All sensory modalities serve a similar objective, which is todecode input by making predictions in time and space aboutan animal’s surroundings. The evolution of sensory modalitiesis driven by the need to shape effective behaviouraloutputs, and in turn increase survival. Throughout evolution,sensory systems have undergone a great deal of specialization;and even though some modalities are derived fromunique origins within different phyla, they still exhibit manycommon design features (Strausfeld and Hildebrand 1999;Eisthen 2002; Jacobs et al. 2007). We now have detailedmechanistic data on how sensory systems operate within specificanimals (Buck and Axel 1991; Chalasani et al. 2007;Sato et al. 2008; Wicher et al. 2008), however it is still notclear how sensory signalling pathways evolve at the molecularlevel, and whether these evolutionary mechanisms areshared between diverse taxa. Here we set out to investigatethe molecular evolution of signalling pathway membersacross olfactory, gustatory, and photosensory modalitiesfrom very divergent phyla in an attempt to develop a modelof molecular evolution for sensory systems. From our pairwiseintraphylum analysis we found that sensory signallingpathways unusually undergo high levels of functional constraintthat are higher than genomewide global levels ofconstraint, and this purifying selection is common withinthe very divergent taxa we examined. We also find thatgene duplication events represent a conserved but heterogeneousdriver of evolution within sensory signalling pathways.Taken together, we propose a ‘sessile’ mechanism ofsensory signalling pathway evolution, which on one sidefacilitates bursts of gene duplication and relaxed selectionand on the other side it is unusually anchored by high levelsof selective constraint that preserves core sensory function." @default.
- W2116718742 created "2016-06-24" @default.
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- W2116718742 date "2013-08-01" @default.
- W2116718742 modified "2023-10-13" @default.
- W2116718742 title "A comparative study of the molecular evolution of signalling pathway members across olfactory, gustatory and photosensory modalities" @default.
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- W2116718742 doi "https://doi.org/10.1007/s12041-013-0264-9" @default.
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