Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116721462> ?p ?o ?g. }
- W2116721462 endingPage "8" @default.
- W2116721462 startingPage "6230" @default.
- W2116721462 abstract "It is generally considered that MHC class I-restricted antigens are recognized by CD8+ T cells, whereas MHC class II-restricted antigens are recognized by CD4+ T cells. In the present study, we report an MHC class I-restricted CD4+ T cell isolated from the tumor infiltrating lymphocytes (TILs) of a patient with metastatic melanoma. TIL 1383 I recognized HLA-A2+ melanoma cell lines but not autologous transformed B cells or fibroblasts. The antigen recognized by TIL 1383 I was tyrosinase, and the epitope was the 368-376 peptide. Antibody blocking assays confirmed that TIL 1383 I was MHC class I restricted, and the CD4 and CD8 coreceptors did not contribute significantly to antigen recognition. TIL 1383 I was weakly cytolytic and secreted cytokines in a pattern consistent with it being a Th1 cell. The avidity of TIL 1383 I for peptide pulsed targets is 10-100-fold lower than most melanoma-reactive CD8+ T cell clones. These CD4+ T cells may represent a relatively rare population of T cells that express a T-cell receptor capable of cross-reacting with an MHC class I/peptide complex with sufficient affinity to allow triggering in the absence of the CD4 coreceptor." @default.
- W2116721462 created "2016-06-24" @default.
- W2116721462 creator A5003338851 @default.
- W2116721462 creator A5013384076 @default.
- W2116721462 creator A5026319326 @default.
- W2116721462 creator A5039197753 @default.
- W2116721462 creator A5051448151 @default.
- W2116721462 creator A5058077037 @default.
- W2116721462 creator A5070763555 @default.
- W2116721462 creator A5071835245 @default.
- W2116721462 creator A5072133376 @default.
- W2116721462 creator A5088896967 @default.
- W2116721462 date "1999-12-15" @default.
- W2116721462 modified "2023-10-17" @default.
- W2116721462 title "MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte." @default.
- W2116721462 cites W1481479990 @default.
- W2116721462 cites W1486249536 @default.
- W2116721462 cites W1512441015 @default.
- W2116721462 cites W1533542807 @default.
- W2116721462 cites W1570009082 @default.
- W2116721462 cites W1575119798 @default.
- W2116721462 cites W1588193878 @default.
- W2116721462 cites W1724933401 @default.
- W2116721462 cites W1829889392 @default.
- W2116721462 cites W1924656799 @default.
- W2116721462 cites W1928212615 @default.
- W2116721462 cites W1963569988 @default.
- W2116721462 cites W1965517166 @default.
- W2116721462 cites W1974787546 @default.
- W2116721462 cites W1978094859 @default.
- W2116721462 cites W1979639859 @default.
- W2116721462 cites W1986046751 @default.
- W2116721462 cites W1988804735 @default.
- W2116721462 cites W1989274143 @default.
- W2116721462 cites W1992275362 @default.
- W2116721462 cites W1992847016 @default.
- W2116721462 cites W1995864071 @default.
- W2116721462 cites W1999502843 @default.
- W2116721462 cites W1999918512 @default.
- W2116721462 cites W2009310436 @default.
- W2116721462 cites W2015257284 @default.
- W2116721462 cites W2016899885 @default.
- W2116721462 cites W2018027744 @default.
- W2116721462 cites W2022881136 @default.
- W2116721462 cites W2024441858 @default.
- W2116721462 cites W2030384073 @default.
- W2116721462 cites W2036374565 @default.
- W2116721462 cites W2038108432 @default.
- W2116721462 cites W2041010325 @default.
- W2116721462 cites W2041751778 @default.
- W2116721462 cites W2046105249 @default.
- W2116721462 cites W2057831214 @default.
- W2116721462 cites W2059166222 @default.
- W2116721462 cites W2060095976 @default.
- W2116721462 cites W2067060947 @default.
- W2116721462 cites W2069417575 @default.
- W2116721462 cites W2072286695 @default.
- W2116721462 cites W2077329371 @default.
- W2116721462 cites W2083556128 @default.
- W2116721462 cites W2089418619 @default.
- W2116721462 cites W2091996781 @default.
- W2116721462 cites W2098591549 @default.
- W2116721462 cites W2114358743 @default.
- W2116721462 cites W2115160431 @default.
- W2116721462 cites W2115454016 @default.
- W2116721462 cites W2117941191 @default.
- W2116721462 cites W2123395438 @default.
- W2116721462 cites W2126804071 @default.
- W2116721462 cites W2130185552 @default.
- W2116721462 cites W2145929767 @default.
- W2116721462 cites W2156000007 @default.
- W2116721462 cites W2161304120 @default.
- W2116721462 cites W2167102170 @default.
- W2116721462 cites W2167991773 @default.
- W2116721462 cites W2169840688 @default.
- W2116721462 cites W22176921 @default.
- W2116721462 cites W2237061118 @default.
- W2116721462 cites W2334712554 @default.
- W2116721462 cites W2434150621 @default.
- W2116721462 cites W2537434271 @default.
- W2116721462 cites W2616244127 @default.
- W2116721462 cites W300315513 @default.
- W2116721462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10626817" @default.
- W2116721462 hasPublicationYear "1999" @default.
- W2116721462 type Work @default.
- W2116721462 sameAs 2116721462 @default.
- W2116721462 citedByCount "37" @default.
- W2116721462 countsByYear W21167214622012 @default.
- W2116721462 countsByYear W21167214622013 @default.
- W2116721462 countsByYear W21167214622014 @default.
- W2116721462 countsByYear W21167214622015 @default.
- W2116721462 countsByYear W21167214622016 @default.
- W2116721462 countsByYear W21167214622017 @default.
- W2116721462 countsByYear W21167214622020 @default.
- W2116721462 countsByYear W21167214622021 @default.
- W2116721462 countsByYear W21167214622022 @default.
- W2116721462 crossrefType "journal-article" @default.
- W2116721462 hasAuthorship W2116721462A5003338851 @default.