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- W2116721643 abstract "The effect of an acute nonspecific inflammatory exudate with mitogenic activity for macrophages in culture has been tested on the spontaneous and PHA-induced DNA synthesis by spleen cells in vitro. Stimulatory effect of this exudate was observed on the spontaneous DNA synthesis which was detectable over a range of 1:4 to 1:4096 concentrations. After optimal PHA stimulation, an inhibition of mitogen-induced DNA synthesis was observed when the cells were exposed to the highest concentrations (up to 1:128) of the exudate. Thereafter, the phenomenon could be reversed and the stimulation was maximal at the concentration of 1:2048. When a suboptimal dose of PHA was used, the stimulatory effect was more pronounced and detected from 1:8 up to 1:4096 concentrations." @default.
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- W2116721643 date "1979-01-01" @default.
- W2116721643 modified "2023-09-25" @default.
- W2116721643 title "In Vitro Effect of an Acute Nonspecific Inflammatory Exudate on Tritiated-Thymidine Incorporation by Unstimulated and Pha-Stimulated Spleen Cells" @default.
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- W2116721643 doi "https://doi.org/10.3109/08923977909040550" @default.
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