Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116722393> ?p ?o ?g. }
- W2116722393 abstract "Obesity-associated organ-specific pathological states can be ensued from the dysregulation of the functions of the adipose tissues, liver and muscle. However, the influence of genetic differences underlying gross-compositional differences in these tissues is largely unknown. In the present study, the analytical method of ATR-FTIR spectroscopy has been combined with a genetic approach to identify genetic differences responsible for phenotypic alterations in adipose, liver and muscle tissues.Mice from 29 BXD recombinant inbred mouse strains were put on high fat diet and gross-compositional changes in adipose, liver and muscle tissues were measured by ATR-FTIR spectroscopy. The analysis of genotype-phenotype correlations revealed significant quantitative trait loci (QTL) on chromosome 12 for the content of fat and collagen, collagen integrity, and the lipid to protein ratio in adipose tissue and on chromosome 17 for lipid to protein ratio in liver. Using gene expression and sequence information, we suggest Rsad2 (viperin) and Colec11 (collectin-11) on chromosome 12 as potential quantitative trait candidate genes. Rsad2 may act as a modulator of lipid droplet contents and lipid biosynthesis; Colec11 might play a role in apoptopic cell clearance and maintenance of adipose tissue. An increased level of Rsad2 transcripts in adipose tissue of DBA/2J compared to C57BL/6J mice suggests a cis-acting genetic variant leading to differential gene activation.The results demonstrate that the analytical method of ATR-FTIR spectroscopy effectively contributed to decompose the macromolecular composition of tissues that accumulate fat and to link this information with genetic determinants. The candidate genes in the QTL regions may contribute to obesity-related diseases in humans, in particular if the results can be verified in a bigger BXD cohort." @default.
- W2116722393 created "2016-06-24" @default.
- W2116722393 creator A5003987814 @default.
- W2116722393 creator A5018015355 @default.
- W2116722393 creator A5023253476 @default.
- W2116722393 creator A5027845799 @default.
- W2116722393 creator A5038499176 @default.
- W2116722393 creator A5066785735 @default.
- W2116722393 creator A5086552188 @default.
- W2116722393 creator A5087243794 @default.
- W2116722393 date "2013-06-10" @default.
- W2116722393 modified "2023-10-09" @default.
- W2116722393 title "ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains" @default.
- W2116722393 cites W1909063372 @default.
- W2116722393 cites W1964540224 @default.
- W2116722393 cites W1967809548 @default.
- W2116722393 cites W1971583765 @default.
- W2116722393 cites W1977615915 @default.
- W2116722393 cites W1980740976 @default.
- W2116722393 cites W1982302968 @default.
- W2116722393 cites W1983152416 @default.
- W2116722393 cites W1991745307 @default.
- W2116722393 cites W1998726695 @default.
- W2116722393 cites W1998979801 @default.
- W2116722393 cites W2002774545 @default.
- W2116722393 cites W2003432332 @default.
- W2116722393 cites W2004128332 @default.
- W2116722393 cites W2010331750 @default.
- W2116722393 cites W2030545744 @default.
- W2116722393 cites W2033442194 @default.
- W2116722393 cites W2037141003 @default.
- W2116722393 cites W2043448554 @default.
- W2116722393 cites W2046295202 @default.
- W2116722393 cites W2047389654 @default.
- W2116722393 cites W2052932569 @default.
- W2116722393 cites W2054189556 @default.
- W2116722393 cites W2058585906 @default.
- W2116722393 cites W2060823593 @default.
- W2116722393 cites W2064385142 @default.
- W2116722393 cites W2064635892 @default.
- W2116722393 cites W2067080331 @default.
- W2116722393 cites W2069028567 @default.
- W2116722393 cites W2074881183 @default.
- W2116722393 cites W2077855062 @default.
- W2116722393 cites W2080030546 @default.
- W2116722393 cites W2091011250 @default.
- W2116722393 cites W2092209130 @default.
- W2116722393 cites W2092498488 @default.
- W2116722393 cites W2102231656 @default.
- W2116722393 cites W2107277218 @default.
- W2116722393 cites W2108334325 @default.
- W2116722393 cites W2109372707 @default.
- W2116722393 cites W2112886301 @default.
- W2116722393 cites W2113716007 @default.
- W2116722393 cites W2117007075 @default.
- W2116722393 cites W2125860227 @default.
- W2116722393 cites W2128977956 @default.
- W2116722393 cites W2129720760 @default.
- W2116722393 cites W2133481218 @default.
- W2116722393 cites W2136899851 @default.
- W2116722393 cites W2139651996 @default.
- W2116722393 cites W2147004068 @default.
- W2116722393 cites W2147127785 @default.
- W2116722393 cites W2147507929 @default.
- W2116722393 cites W2150866799 @default.
- W2116722393 cites W2162405125 @default.
- W2116722393 cites W2163691580 @default.
- W2116722393 cites W2168790777 @default.
- W2116722393 cites W2169702966 @default.
- W2116722393 cites W4239489129 @default.
- W2116722393 cites W4294216491 @default.
- W2116722393 cites W564189437 @default.
- W2116722393 doi "https://doi.org/10.1186/1471-2164-14-386" @default.
- W2116722393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3717084" @default.
- W2116722393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23758785" @default.
- W2116722393 hasPublicationYear "2013" @default.
- W2116722393 type Work @default.
- W2116722393 sameAs 2116722393 @default.
- W2116722393 citedByCount "47" @default.
- W2116722393 countsByYear W21167223932013 @default.
- W2116722393 countsByYear W21167223932014 @default.
- W2116722393 countsByYear W21167223932015 @default.
- W2116722393 countsByYear W21167223932016 @default.
- W2116722393 countsByYear W21167223932017 @default.
- W2116722393 countsByYear W21167223932018 @default.
- W2116722393 countsByYear W21167223932019 @default.
- W2116722393 countsByYear W21167223932020 @default.
- W2116722393 countsByYear W21167223932021 @default.
- W2116722393 countsByYear W21167223932022 @default.
- W2116722393 countsByYear W21167223932023 @default.
- W2116722393 crossrefType "journal-article" @default.
- W2116722393 hasAuthorship W2116722393A5003987814 @default.
- W2116722393 hasAuthorship W2116722393A5018015355 @default.
- W2116722393 hasAuthorship W2116722393A5023253476 @default.
- W2116722393 hasAuthorship W2116722393A5027845799 @default.
- W2116722393 hasAuthorship W2116722393A5038499176 @default.
- W2116722393 hasAuthorship W2116722393A5066785735 @default.
- W2116722393 hasAuthorship W2116722393A5086552188 @default.
- W2116722393 hasAuthorship W2116722393A5087243794 @default.
- W2116722393 hasBestOaLocation W21167223931 @default.