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- W2116723626 endingPage "274" @default.
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- W2116723626 abstract "The distribution of the phytohormone auxin regulates many aspects of plant development including growth response to gravity. Gravitropic root curvature involves coordinated and asymmetric cell elongation between the lower and upper side of the root, mediated by differential cellular auxin levels. The asymmetry in the auxin distribution is established and maintained by a spatio-temporal regulation of the PIN-FORMED (PIN) auxin transporter activity. We provide novel insights into the complex regulation of PIN abundance and activity during root gravitropism. We show that PIN2 turnover is differentially regulated on the upper and lower side of gravistimulated roots by distinct but partially overlapping auxin feedback mechanisms. In addition to regulating transcription and clathrin-mediated internalization, auxin also controls PIN abundance at the plasma membrane by promoting their vacuolar targeting and degradation. This effect of elevated auxin levels requires the activity of SKP-Cullin-F-box(TIR1/AFB) (SCF(TIR1/AFB))-dependent pathway. Importantly, also suboptimal auxin levels mediate PIN degradation utilizing the same signalling pathway. These feedback mechanisms are functionally important during gravitropic response and ensure fine-tuning of auxin fluxes for maintaining as well as terminating asymmetric growth." @default.
- W2116723626 created "2016-06-24" @default.
- W2116723626 creator A5003304168 @default.
- W2116723626 creator A5011795455 @default.
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- W2116723626 creator A5030974588 @default.
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- W2116723626 creator A5053770992 @default.
- W2116723626 creator A5090525348 @default.
- W2116723626 creator A5091233146 @default.
- W2116723626 date "2012-12-04" @default.
- W2116723626 modified "2023-09-25" @default.
- W2116723626 title "SCFTIR1/AFB-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism" @default.
- W2116723626 cites W1508280446 @default.
- W2116723626 cites W1574153472 @default.
- W2116723626 cites W1854744571 @default.
- W2116723626 cites W1900359431 @default.
- W2116723626 cites W1924812281 @default.
- W2116723626 cites W1926711179 @default.
- W2116723626 cites W1965369628 @default.
- W2116723626 cites W1968079819 @default.
- W2116723626 cites W1968503465 @default.
- W2116723626 cites W1970396605 @default.
- W2116723626 cites W1972633502 @default.
- W2116723626 cites W1975053636 @default.
- W2116723626 cites W1975288257 @default.
- W2116723626 cites W1987913274 @default.
- W2116723626 cites W1988692634 @default.
- W2116723626 cites W1990813383 @default.
- W2116723626 cites W1992440587 @default.
- W2116723626 cites W1994303360 @default.
- W2116723626 cites W1998141700 @default.
- W2116723626 cites W1998899958 @default.
- W2116723626 cites W2002821316 @default.
- W2116723626 cites W2003971502 @default.
- W2116723626 cites W2004608542 @default.
- W2116723626 cites W2004979058 @default.
- W2116723626 cites W2005766850 @default.
- W2116723626 cites W2006745977 @default.
- W2116723626 cites W2008642796 @default.
- W2116723626 cites W2009849705 @default.
- W2116723626 cites W2012241965 @default.
- W2116723626 cites W2012352145 @default.
- W2116723626 cites W2012537143 @default.
- W2116723626 cites W2014207396 @default.
- W2116723626 cites W2024692287 @default.
- W2116723626 cites W2029089518 @default.
- W2116723626 cites W2029981308 @default.
- W2116723626 cites W2031199055 @default.
- W2116723626 cites W2031213514 @default.
- W2116723626 cites W2043371550 @default.
- W2116723626 cites W2046262753 @default.
- W2116723626 cites W2052981544 @default.
- W2116723626 cites W2053826886 @default.
- W2116723626 cites W2060162734 @default.
- W2116723626 cites W2061864042 @default.
- W2116723626 cites W2065596167 @default.
- W2116723626 cites W2068315132 @default.
- W2116723626 cites W2068588120 @default.
- W2116723626 cites W2071707788 @default.
- W2116723626 cites W2072403742 @default.
- W2116723626 cites W2074764991 @default.
- W2116723626 cites W2078959581 @default.
- W2116723626 cites W2081310354 @default.
- W2116723626 cites W2084243212 @default.
- W2116723626 cites W2086654822 @default.
- W2116723626 cites W2089118630 @default.
- W2116723626 cites W2091407052 @default.
- W2116723626 cites W2096008409 @default.
- W2116723626 cites W2097943925 @default.
- W2116723626 cites W2099213570 @default.
- W2116723626 cites W2100450391 @default.
- W2116723626 cites W2101838085 @default.
- W2116723626 cites W2104088099 @default.
- W2116723626 cites W2104507604 @default.
- W2116723626 cites W2104766562 @default.
- W2116723626 cites W2107344774 @default.
- W2116723626 cites W2110007114 @default.
- W2116723626 cites W2110398660 @default.
- W2116723626 cites W2112660950 @default.
- W2116723626 cites W2116270477 @default.
- W2116723626 cites W2117234604 @default.
- W2116723626 cites W2118387951 @default.
- W2116723626 cites W2118483745 @default.
- W2116723626 cites W2119022968 @default.
- W2116723626 cites W2120030399 @default.
- W2116723626 cites W2123134178 @default.
- W2116723626 cites W2124659894 @default.
- W2116723626 cites W2124989020 @default.
- W2116723626 cites W2127011094 @default.
- W2116723626 cites W2128535348 @default.
- W2116723626 cites W2129245810 @default.
- W2116723626 cites W2129415717 @default.
- W2116723626 cites W2131399365 @default.
- W2116723626 cites W2133078492 @default.
- W2116723626 cites W2133671289 @default.
- W2116723626 cites W2137231405 @default.