Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116724545> ?p ?o ?g. }
- W2116724545 endingPage "50" @default.
- W2116724545 startingPage "39" @default.
- W2116724545 abstract "The 26S proteasome degrades polyubiquitinated proteins by an energy-dependent mechanism. Here we define multiple roles for ATP in 26S proteasome function. ATP binding is necessary and sufficient for assembly of 26S proteasome from 20S proteasome and PA700/19S subcomplexes and for proteasome activation. Proteasome assembly and activation may require distinct ATP binding events. The 26S proteasome degrades nonubiquitylated, unstructured proteins without ATP hydrolysis, indicating that substrate translocation per se does not require the energy of hydrolysis. Nonubiquitylated folded proteins and certain polyubiquitylated folded proteins were refractory to proteolysis. The latter were deubiquitylated by an ATP-independent mechanism. Other folded as well as unstructured polyubiquitylated proteins required ATP hydrolysis for proteolysis and deubiquitylation. Thus, ATP hydrolysis is not used solely for substrate unfolding. These results indicate that 26S proteasome-catalyzed degradation of polyubiquitylated proteins involves mechanistic coupling of several processes and that such coupling imposes an energy requirement not apparent for any isolated process." @default.
- W2116724545 created "2016-06-24" @default.
- W2116724545 creator A5029136277 @default.
- W2116724545 creator A5030985240 @default.
- W2116724545 creator A5041421104 @default.
- W2116724545 creator A5042047114 @default.
- W2116724545 creator A5042262419 @default.
- W2116724545 creator A5042296036 @default.
- W2116724545 creator A5051450242 @default.
- W2116724545 creator A5067456104 @default.
- W2116724545 creator A5071814939 @default.
- W2116724545 date "2006-10-01" @default.
- W2116724545 modified "2023-09-26" @default.
- W2116724545 title "ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome" @default.
- W2116724545 cites W1490867178 @default.
- W2116724545 cites W1493327795 @default.
- W2116724545 cites W1532285380 @default.
- W2116724545 cites W1532810559 @default.
- W2116724545 cites W1947552193 @default.
- W2116724545 cites W1970818558 @default.
- W2116724545 cites W1978131501 @default.
- W2116724545 cites W1980378067 @default.
- W2116724545 cites W1984555522 @default.
- W2116724545 cites W1991915276 @default.
- W2116724545 cites W1991930087 @default.
- W2116724545 cites W1992875450 @default.
- W2116724545 cites W1999119754 @default.
- W2116724545 cites W1999489386 @default.
- W2116724545 cites W2000596494 @default.
- W2116724545 cites W2001383742 @default.
- W2116724545 cites W2005993899 @default.
- W2116724545 cites W2013339424 @default.
- W2116724545 cites W2020462325 @default.
- W2116724545 cites W2026632566 @default.
- W2116724545 cites W2035233115 @default.
- W2116724545 cites W2038751264 @default.
- W2116724545 cites W2038852478 @default.
- W2116724545 cites W2044318442 @default.
- W2116724545 cites W2050706542 @default.
- W2116724545 cites W2051022720 @default.
- W2116724545 cites W2054030208 @default.
- W2116724545 cites W2055544854 @default.
- W2116724545 cites W2056431359 @default.
- W2116724545 cites W2060354742 @default.
- W2116724545 cites W2069494008 @default.
- W2116724545 cites W2090825527 @default.
- W2116724545 cites W2092421259 @default.
- W2116724545 cites W2114532452 @default.
- W2116724545 cites W2115682866 @default.
- W2116724545 cites W2119058502 @default.
- W2116724545 cites W2119883540 @default.
- W2116724545 cites W2123781000 @default.
- W2116724545 cites W2126467039 @default.
- W2116724545 cites W2142316927 @default.
- W2116724545 cites W2147557127 @default.
- W2116724545 cites W2152424535 @default.
- W2116724545 cites W2157193371 @default.
- W2116724545 cites W2162223351 @default.
- W2116724545 cites W2164710551 @default.
- W2116724545 cites W2178503716 @default.
- W2116724545 cites W2414386245 @default.
- W2116724545 cites W4255738047 @default.
- W2116724545 doi "https://doi.org/10.1016/j.molcel.2006.08.025" @default.
- W2116724545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3951175" @default.
- W2116724545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17018291" @default.
- W2116724545 hasPublicationYear "2006" @default.
- W2116724545 type Work @default.
- W2116724545 sameAs 2116724545 @default.
- W2116724545 citedByCount "171" @default.
- W2116724545 countsByYear W21167245452012 @default.
- W2116724545 countsByYear W21167245452013 @default.
- W2116724545 countsByYear W21167245452014 @default.
- W2116724545 countsByYear W21167245452015 @default.
- W2116724545 countsByYear W21167245452016 @default.
- W2116724545 countsByYear W21167245452017 @default.
- W2116724545 countsByYear W21167245452018 @default.
- W2116724545 countsByYear W21167245452019 @default.
- W2116724545 countsByYear W21167245452020 @default.
- W2116724545 countsByYear W21167245452021 @default.
- W2116724545 countsByYear W21167245452022 @default.
- W2116724545 countsByYear W21167245452023 @default.
- W2116724545 crossrefType "journal-article" @default.
- W2116724545 hasAuthorship W2116724545A5029136277 @default.
- W2116724545 hasAuthorship W2116724545A5030985240 @default.
- W2116724545 hasAuthorship W2116724545A5041421104 @default.
- W2116724545 hasAuthorship W2116724545A5042047114 @default.
- W2116724545 hasAuthorship W2116724545A5042262419 @default.
- W2116724545 hasAuthorship W2116724545A5042296036 @default.
- W2116724545 hasAuthorship W2116724545A5051450242 @default.
- W2116724545 hasAuthorship W2116724545A5067456104 @default.
- W2116724545 hasAuthorship W2116724545A5071814939 @default.
- W2116724545 hasBestOaLocation W21167245451 @default.
- W2116724545 hasConcept C104317684 @default.
- W2116724545 hasConcept C14036430 @default.
- W2116724545 hasConcept C141315368 @default.
- W2116724545 hasConcept C181199279 @default.
- W2116724545 hasConcept C23265538 @default.
- W2116724545 hasConcept C25602115 @default.