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- W2116724819 abstract "The Alzheimer disease (AD) is the main cause of dementia in the world, constitutes one of the most common forms of senile and presenile dementia in ageing subjects. The attention has gone to the possible contribution of the mitochondrial dysfunction, and it has been suggested that some defects in the metabolism could be implied in pathogenesis of the AD. The aim of the present work was the study of the membrane fluidity in sub-mitochondrial platelet particles and erythrocyte membranes from Mexican patients with Alzheimer probable. Blood samples were obtained from 30 patients who attended the Hospital de Especialidades (UMAE) del Centro Médico Nacional de Occidente at Guadalajara, Jalisco, México, with diagnosis of Alzheimer probable. Membrane fluidity determinations were done using a very low concentration of the fluorescent dipyrenylpropane (DPP) probe incorporated in both types of membranes. This probe is able to give excimer and monomer fluorescence, therefore it can be used to monitor fluidity changes in biological membranes. Submitochondrial particles from platelets and white ghosts from erythrocytes were tested for lipid peroxidation. At the same concentration of membranes both spectra shows absolute differences in monomer and excimer fluorescences in samples from patients and controls. Principally, the monomer emission is higher in AD patients than controls. The excimer to monomer fluorescent intensity ratios were calculated, in the patients the ratio was lower than in aged-matched control. In erythrocyte membranes the fluorescence intensity ratio was similar in both. Lipid peroxidation was higher in AD samples than aged-matched controls. At the moment we do not known whether the diminished membrane fluidity in AD is etiologically significant or a minor result of neurodegeneration. On the other side, These data suggest that submitochondrial platelet particles are more sensitive to oxidative stress than erythrocyte membranes." @default.
- W2116724819 created "2016-06-24" @default.
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- W2116724819 date "2008-07-01" @default.
- W2116724819 modified "2023-09-27" @default.
- W2116724819 title "P4-187: Membrane fluidity in platelets and erythrocite of Mexican patients with probable Alzheimer's disease using an intramolecular excimer formation of 1,3 dipyrenylpropane" @default.
- W2116724819 doi "https://doi.org/10.1016/j.jalz.2008.05.2254" @default.
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