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- W2116725685 abstract "ABSTRACT – The effect of myelin basic protein (MBP) of central nervous tissue on the protease inhibitors, alpha1 antitrypsin (a1AT) and alpha2macroglobulin (a2M) was studied in vitro. For this purpose, 2 characteristics of the protease inhibitors were used, viz. their pattern after isoelectric focusing and their trypsin-binding capacity. Both features of purified a2AT disappeared in the presence of MBP. The tests with a2M revealed that the formation and stability of the complex between a2M and protease were reduced. The results of this study suggest that MBP causes an increase in proteolytic activity by inactivating protease inhibitors. The potential relevance of these results for demyeli-nating processes in man and animal is discussed." @default.
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- W2116725685 date "2009-01-29" @default.
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- W2116725685 title "The effect of myelin basic protein on the protease inhibitors alpha1 antitrypsin and alpha2macroglobulin" @default.
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- W2116725685 doi "https://doi.org/10.1111/j.1600-0404.1985.tb03189.x" @default.
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