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- W2116727149 abstract "Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions on human B-cell numbers and function are largely unknown. Using transgenic mice expressing fully human immunoglobulins, we studied the consequences of in vivo exposure of protein L of Peptostreptococcus magnus with human immunoglobulins. In the mature pool of B cells, protein L exposure resulted in a specific reduction of splenic marginal-zone B cells and peritoneal B-1 cells. Splenic B cells exhibited a skewed light-chain repertoire consistent with the capacity of protein L to bind specific kappa gene products. Remarkably, these two B-cell subsets are implicated in innate B-cell immunity, allowing rapid clearance of pathogens. Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense." @default.
- W2116727149 created "2016-06-24" @default.
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- W2116727149 creator A5044646486 @default.
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- W2116727149 date "2004-06-01" @default.
- W2116727149 modified "2023-09-25" @default.
- W2116727149 title "Specific In Vivo Deletion of B-Cell Subpopulations Expressing Human Immunoglobulins by the B-Cell Superantigen Protein L" @default.
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- W2116727149 doi "https://doi.org/10.1128/iai.72.6.3515-3523.2004" @default.
- W2116727149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/415702" @default.
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- W2116727149 hasPublicationYear "2004" @default.
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