FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116728985> ?p ?o ?g. }

• W2116728985 endingPage "1509" @default.
• W2116728985 startingPage "1503" @default.
• W2116728985 abstract "In the present study, in order to analyze abnormalities in DNA methylation in glioma, we utilized a large cohort methylation microarray (119 glioma samples). Genes associated with tumor grade progression were screened through Significance Analysis of Microarrays (SAM) in the methylation microarray. We found that Rab27b was hypomethylated in high-grade glioma (anaplastic gliomas and glioblastomas) compared with low-grade glioma (astrocytoma, oligodendrocytoma and oligoastrocytoma) (p=0.02). In 52 glioma samples, we determined both the methylation status of the Rab27b promoter region and protein expression, and confirmed a negative correlation between the methylation status and expression (p<0.01). Immunohistochemistry of 91 gliomas revealed that the Rab27b expression scores of high-grade glioma were higher than scores of low-grade gliomas (p<0.01). In high‑grade gliomas, patients haboring Rab27b hypomethylation or overexpression had unfavorable survival prognosis. Transwell invasion assays identified that invasive cell number of glioma U87 and LN229 cells decreased when Rab27b was knocked down. Decreased invasion partly resulted from reduced expression and activation of MMP-9 after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo. Hypomethylated Rab27b was identified as a progression-associated and prognostic molecular marker of glioma." @default.
• W2116728985 created "2016-06-24" @default.
• W2116728985 creator A5000583642 @default.
• W2116728985 creator A5005168346 @default.
• W2116728985 creator A5039448133 @default.
• W2116728985 creator A5059065312 @default.
• W2116728985 creator A5079262508 @default.
• W2116728985 creator A5081369124 @default.
• W2116728985 date "2015-07-13" @default.
• W2116728985 modified "2023-10-14" @default.
• W2116728985 title "Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion" @default.
• W2116728985 cites W1978207919 @default.
• W2116728985 cites W1984807040 @default.
• W2116728985 cites W1999232604 @default.
• W2116728985 cites W2015226869 @default.
• W2116728985 cites W2019679477 @default.
• W2116728985 cites W2024819383 @default.
• W2116728985 cites W2043033879 @default.
• W2116728985 cites W2048283358 @default.
• W2116728985 cites W2082780838 @default.
• W2116728985 cites W2095491090 @default.
• W2116728985 cites W2130722148 @default.
• W2116728985 cites W2139009744 @default.
• W2116728985 cites W2141410747 @default.
• W2116728985 cites W2147518722 @default.
• W2116728985 cites W2149814701 @default.
• W2116728985 cites W2149840758 @default.
• W2116728985 cites W2160202949 @default.
• W2116728985 cites W2160507620 @default.
• W2116728985 doi "https://doi.org/10.3892/or.2015.4125" @default.
• W2116728985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26165699" @default.
• W2116728985 hasPublicationYear "2015" @default.
• W2116728985 type Work @default.
• W2116728985 sameAs 2116728985 @default.
• W2116728985 citedByCount "14" @default.
• W2116728985 countsByYear W21167289852016 @default.
• W2116728985 countsByYear W21167289852017 @default.
• W2116728985 countsByYear W21167289852018 @default.
• W2116728985 countsByYear W21167289852019 @default.
• W2116728985 countsByYear W21167289852020 @default.
• W2116728985 countsByYear W21167289852022 @default.
• W2116728985 crossrefType "journal-article" @default.
• W2116728985 hasAuthorship W2116728985A5000583642 @default.
• W2116728985 hasAuthorship W2116728985A5005168346 @default.
• W2116728985 hasAuthorship W2116728985A5039448133 @default.
• W2116728985 hasAuthorship W2116728985A5059065312 @default.
• W2116728985 hasAuthorship W2116728985A5079262508 @default.
• W2116728985 hasAuthorship W2116728985A5081369124 @default.
• W2116728985 hasBestOaLocation W21167289851 @default.
• W2116728985 hasConcept C104317684 @default.
• W2116728985 hasConcept C121608353 @default.
• W2116728985 hasConcept C142724271 @default.
• W2116728985 hasConcept C150194340 @default.
• W2116728985 hasConcept C190727270 @default.
• W2116728985 hasConcept C193270364 @default.
• W2116728985 hasConcept C203014093 @default.
• W2116728985 hasConcept C204232928 @default.
• W2116728985 hasConcept C2778227246 @default.
• W2116728985 hasConcept C2779256057 @default.
• W2116728985 hasConcept C2781018059 @default.
• W2116728985 hasConcept C29537977 @default.
• W2116728985 hasConcept C33288867 @default.
• W2116728985 hasConcept C502942594 @default.
• W2116728985 hasConcept C54355233 @default.
• W2116728985 hasConcept C71924100 @default.
• W2116728985 hasConcept C86803240 @default.
• W2116728985 hasConceptScore W2116728985C104317684 @default.
• W2116728985 hasConceptScore W2116728985C121608353 @default.
• W2116728985 hasConceptScore W2116728985C142724271 @default.
• W2116728985 hasConceptScore W2116728985C150194340 @default.
• W2116728985 hasConceptScore W2116728985C190727270 @default.
• W2116728985 hasConceptScore W2116728985C193270364 @default.
• W2116728985 hasConceptScore W2116728985C203014093 @default.
• W2116728985 hasConceptScore W2116728985C204232928 @default.
• W2116728985 hasConceptScore W2116728985C2778227246 @default.
• W2116728985 hasConceptScore W2116728985C2779256057 @default.
• W2116728985 hasConceptScore W2116728985C2781018059 @default.
• W2116728985 hasConceptScore W2116728985C29537977 @default.
• W2116728985 hasConceptScore W2116728985C33288867 @default.
• W2116728985 hasConceptScore W2116728985C502942594 @default.
• W2116728985 hasConceptScore W2116728985C54355233 @default.
• W2116728985 hasConceptScore W2116728985C71924100 @default.
• W2116728985 hasConceptScore W2116728985C86803240 @default.
• W2116728985 hasIssue "3" @default.
• W2116728985 hasLocation W21167289851 @default.
• W2116728985 hasLocation W21167289852 @default.
• W2116728985 hasOpenAccess W2116728985 @default.
• W2116728985 hasPrimaryLocation W21167289851 @default.
• W2116728985 hasRelatedWork W2111518609 @default.
• W2116728985 hasRelatedWork W2152835042 @default.
• W2116728985 hasRelatedWork W2179057393 @default.
• W2116728985 hasRelatedWork W2273074945 @default.
• W2116728985 hasRelatedWork W2334588356 @default.
• W2116728985 hasRelatedWork W2508252533 @default.
• W2116728985 hasRelatedWork W2734795627 @default.
• W2116728985 hasRelatedWork W2902203810 @default.
• W2116728985 hasRelatedWork W2988175535 @default.
• W2116728985 hasRelatedWork W3093025902 @default.

• next