FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116729450> ?p ?o ?g. }

• W2116729450 endingPage "5" @default.
• W2116729450 startingPage "310" @default.
• W2116729450 abstract "We studied the relationship between in vitro bacteriological parameters [minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and killing rate, defined as the reduction in the inoculum within 1, 3 or 6 hr] and in vivo activity of amoxicillin against 12 strains of Streptococcus pneumoniae, with penicillin MICs of < 0.01 to 16 micrograms/ml, in a cyclophosphamide-induced neutropenic murine pneumonia model. Dose-response curves were determined for amoxicillin against each strain, and three quantitative parameters of in vivo amoxicillin activity were defined, i.e., maximal attainable antimicrobial effect attributable to the drug [i.e., reduction in log colony-forming units (CFU) per lung, compared with untreated controls], dose required to reach 50% of maximal effect and dose required to achieve a reduction of 1 log CFU/lung. We demonstrated a highly significant correlation between the dose required to reach 50% of maximal effect and MIC (Spearman r = 0.98, P < .0001) or MBC (Spearman r = 0.95, P < .0001) for amoxicillin against strains of S. pneumoniae with a wide range of amoxicillin MICs (0.01-8 micrograms/ml). Significant correlations between the dose required to achieve a reduction of 1 log CFU/lung and MIC (Spearman r = 0.98, P < .0001) or MBC (Spearman r = 0.95, P < .0001) were also observed. In contrast, there were no significant correlations between the maximal attainable antimicrobial effect attributable to the drug and MIC, MBC or killing rate or between killing rate and the dose required to reach 50% of maximal effect or the dose required to achieve a reduction of 1 log CFU/lung. We conclude that in vitro susceptibility test results (MICs and MBCs) correlated well with in vivo amoxicillin activity against pneumococcal strains, including highly penicillin-resistant strains, in this animal model. Furthermore, these data suggest that the estimated MIC breakpoints for amoxicillin against S. pneumoniae would be 2 micrograms/ml for intermediate-resistant and 4 micrograms/ml for resistant, although this remains to be confirmed in clinical studies." @default.
• W2116729450 created "2016-06-24" @default.
• W2116729450 creator A5042321820 @default.
• W2116729450 creator A5043569651 @default.
• W2116729450 creator A5047900439 @default.
• W2116729450 creator A5055137838 @default.
• W2116729450 creator A5056147744 @default.
• W2116729450 date "1997-01-01" @default.
• W2116729450 modified "2023-09-26" @default.
• W2116729450 title "Correlation between in vitro and in vivo activity of amoxicillin against Streptococcus pneumoniae in a murine pneumonia model." @default.
• W2116729450 cites W1581962345 @default.
• W2116729450 cites W1845427115 @default.
• W2116729450 cites W1923443302 @default.
• W2116729450 cites W1972858790 @default.
• W2116729450 cites W1980846402 @default.
• W2116729450 cites W1986513215 @default.
• W2116729450 cites W1988468718 @default.
• W2116729450 cites W2021344315 @default.
• W2116729450 cites W2033379957 @default.
• W2116729450 cites W2035320583 @default.
• W2116729450 cites W2046740395 @default.
• W2116729450 cites W2060694441 @default.
• W2116729450 cites W2067034394 @default.
• W2116729450 cites W2070567253 @default.
• W2116729450 cites W2070890200 @default.
• W2116729450 cites W2118307170 @default.
• W2116729450 cites W2166840599 @default.
• W2116729450 cites W2337756850 @default.
• W2116729450 cites W2414834203 @default.
• W2116729450 cites W2417629512 @default.
• W2116729450 cites W2418909394 @default.
• W2116729450 cites W2508952649 @default.
• W2116729450 cites W3021839702 @default.
• W2116729450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8996211" @default.
• W2116729450 hasPublicationYear "1997" @default.
• W2116729450 type Work @default.
• W2116729450 sameAs 2116729450 @default.
• W2116729450 citedByCount "7" @default.
• W2116729450 countsByYear W21167294502014 @default.
• W2116729450 countsByYear W21167294502019 @default.
• W2116729450 crossrefType "journal-article" @default.
• W2116729450 hasAuthorship W2116729450A5042321820 @default.
• W2116729450 hasAuthorship W2116729450A5043569651 @default.
• W2116729450 hasAuthorship W2116729450A5047900439 @default.
• W2116729450 hasAuthorship W2116729450A5055137838 @default.
• W2116729450 hasAuthorship W2116729450A5056147744 @default.
• W2116729450 hasConcept C126322002 @default.
• W2116729450 hasConcept C150903083 @default.
• W2116729450 hasConcept C174802600 @default.
• W2116729450 hasConcept C176947019 @default.
• W2116729450 hasConcept C207001950 @default.
• W2116729450 hasConcept C26381139 @default.
• W2116729450 hasConcept C2777914695 @default.
• W2116729450 hasConcept C2779708577 @default.
• W2116729450 hasConcept C2781253189 @default.
• W2116729450 hasConcept C4937899 @default.
• W2116729450 hasConcept C501593827 @default.
• W2116729450 hasConcept C71924100 @default.
• W2116729450 hasConcept C86803240 @default.
• W2116729450 hasConcept C89423630 @default.
• W2116729450 hasConceptScore W2116729450C126322002 @default.
• W2116729450 hasConceptScore W2116729450C150903083 @default.
• W2116729450 hasConceptScore W2116729450C174802600 @default.
• W2116729450 hasConceptScore W2116729450C176947019 @default.
• W2116729450 hasConceptScore W2116729450C207001950 @default.
• W2116729450 hasConceptScore W2116729450C26381139 @default.
• W2116729450 hasConceptScore W2116729450C2777914695 @default.
• W2116729450 hasConceptScore W2116729450C2779708577 @default.
• W2116729450 hasConceptScore W2116729450C2781253189 @default.
• W2116729450 hasConceptScore W2116729450C4937899 @default.
• W2116729450 hasConceptScore W2116729450C501593827 @default.
• W2116729450 hasConceptScore W2116729450C71924100 @default.
• W2116729450 hasConceptScore W2116729450C86803240 @default.
• W2116729450 hasConceptScore W2116729450C89423630 @default.
• W2116729450 hasIssue "1" @default.
• W2116729450 hasLocation W21167294501 @default.
• W2116729450 hasOpenAccess W2116729450 @default.
• W2116729450 hasPrimaryLocation W21167294501 @default.
• W2116729450 hasRelatedWork W1964593885 @default.
• W2116729450 hasRelatedWork W1968755895 @default.
• W2116729450 hasRelatedWork W2015067730 @default.
• W2116729450 hasRelatedWork W2016877036 @default.
• W2116729450 hasRelatedWork W2067307760 @default.
• W2116729450 hasRelatedWork W2113089307 @default.
• W2116729450 hasRelatedWork W2130206282 @default.
• W2116729450 hasRelatedWork W2333869474 @default.
• W2116729450 hasRelatedWork W2394584581 @default.
• W2116729450 hasRelatedWork W2416154929 @default.
• W2116729450 hasVolume "280" @default.
• W2116729450 isParatext "false" @default.
• W2116729450 isRetracted "false" @default.
• W2116729450 magId "2116729450" @default.
• W2116729450 workType "article" @default.