Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116729573> ?p ?o ?g. }
- W2116729573 endingPage "974" @default.
- W2116729573 startingPage "959" @default.
- W2116729573 abstract "Cardiolipin (CL) is a mitochondria-specific phospholipid and is critical for maintaining the integrity of mitochondrial membrane and mitochondrial function. CL also plays an active role in mitochondria-dependent apoptosis by interacting with cytochrome c (cyt c), tBid and other important Bcl-2 proteins. The unique structure of CL with four linoleic acid side chains in the same molecule and its cellular location make it extremely susceptible to free radical oxidation by reactive oxygen species including free radicals derived from peroxidase activity of cyt c/CL complex, singlet oxygen and hydroxyl radical. The free radical oxidation products of CL have been emerged as important mediators in apoptosis. In this review, we summarize the free radical chemical mechanisms that lead to CL oxidation, recent development in detection of oxidation products of CL by mass spectrometry and the implication of CL oxidation in mitochondria-mediated apoptosis, mitochondrial dysfunction and human diseases." @default.
- W2116729573 created "2016-06-24" @default.
- W2116729573 creator A5033395501 @default.
- W2116729573 creator A5085758047 @default.
- W2116729573 date "2012-04-10" @default.
- W2116729573 modified "2023-10-12" @default.
- W2116729573 title "Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases" @default.
- W2116729573 cites W1502736133 @default.
- W2116729573 cites W1514650462 @default.
- W2116729573 cites W1528360418 @default.
- W2116729573 cites W1568406795 @default.
- W2116729573 cites W1569409978 @default.
- W2116729573 cites W1572695420 @default.
- W2116729573 cites W1607459610 @default.
- W2116729573 cites W1621705652 @default.
- W2116729573 cites W163606371 @default.
- W2116729573 cites W1836073275 @default.
- W2116729573 cites W1916661321 @default.
- W2116729573 cites W1934175771 @default.
- W2116729573 cites W1972482460 @default.
- W2116729573 cites W1973685796 @default.
- W2116729573 cites W1974145389 @default.
- W2116729573 cites W1977178308 @default.
- W2116729573 cites W1978896699 @default.
- W2116729573 cites W1982333316 @default.
- W2116729573 cites W1982940971 @default.
- W2116729573 cites W1983227864 @default.
- W2116729573 cites W1984153538 @default.
- W2116729573 cites W1986286467 @default.
- W2116729573 cites W1986330449 @default.
- W2116729573 cites W1986448105 @default.
- W2116729573 cites W1986568749 @default.
- W2116729573 cites W1988058885 @default.
- W2116729573 cites W1994568480 @default.
- W2116729573 cites W1996049054 @default.
- W2116729573 cites W1996421661 @default.
- W2116729573 cites W1999378703 @default.
- W2116729573 cites W2001125684 @default.
- W2116729573 cites W2004505025 @default.
- W2116729573 cites W2004706975 @default.
- W2116729573 cites W2006618203 @default.
- W2116729573 cites W2007130017 @default.
- W2116729573 cites W2008117286 @default.
- W2116729573 cites W2009774232 @default.
- W2116729573 cites W2010130396 @default.
- W2116729573 cites W2011222045 @default.
- W2116729573 cites W2011692072 @default.
- W2116729573 cites W2012173926 @default.
- W2116729573 cites W2013364831 @default.
- W2116729573 cites W2014447062 @default.
- W2116729573 cites W2014856320 @default.
- W2116729573 cites W2015032452 @default.
- W2116729573 cites W2015073045 @default.
- W2116729573 cites W2015643261 @default.
- W2116729573 cites W2016079109 @default.
- W2116729573 cites W2018004244 @default.
- W2116729573 cites W2018490812 @default.
- W2116729573 cites W2018803135 @default.
- W2116729573 cites W2019802526 @default.
- W2116729573 cites W2020670611 @default.
- W2116729573 cites W2023625934 @default.
- W2116729573 cites W2023677185 @default.
- W2116729573 cites W2024126616 @default.
- W2116729573 cites W2027542078 @default.
- W2116729573 cites W2028732326 @default.
- W2116729573 cites W2029314163 @default.
- W2116729573 cites W2029539165 @default.
- W2116729573 cites W2029710274 @default.
- W2116729573 cites W2031889189 @default.
- W2116729573 cites W2032508526 @default.
- W2116729573 cites W2035351765 @default.
- W2116729573 cites W2037199975 @default.
- W2116729573 cites W2037789216 @default.
- W2116729573 cites W2039330812 @default.
- W2116729573 cites W2039950693 @default.
- W2116729573 cites W2041766154 @default.
- W2116729573 cites W2041982853 @default.
- W2116729573 cites W2042200677 @default.
- W2116729573 cites W2045166141 @default.
- W2116729573 cites W2045594395 @default.
- W2116729573 cites W2045765337 @default.
- W2116729573 cites W2046797281 @default.
- W2116729573 cites W2050547972 @default.
- W2116729573 cites W2052261183 @default.
- W2116729573 cites W2054739775 @default.
- W2116729573 cites W2055461508 @default.
- W2116729573 cites W2056578576 @default.
- W2116729573 cites W2057129789 @default.
- W2116729573 cites W2057713121 @default.
- W2116729573 cites W2058096429 @default.
- W2116729573 cites W2059015164 @default.
- W2116729573 cites W2059328944 @default.
- W2116729573 cites W2060035882 @default.
- W2116729573 cites W2060981140 @default.
- W2116729573 cites W2062853648 @default.
- W2116729573 cites W2062897750 @default.
- W2116729573 cites W2063362926 @default.
- W2116729573 cites W2066817189 @default.